Patents Assigned to Roche Diagnostics International AG
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Publication number: 20200152335Abstract: A method is described herein to detect and treat hypoglycemia. An example of this method involves the detection of hypoglycemia in a patient with a computing device, computation of a recommended carbohydrate amount to ingest by the patient with the computing device in response to said detecting the hypoglycemia, output of the recommended carbohydrate amount with the computing device, and the performance of a hypoglycemia surveillance with the computing device to determine whether the recommended carbohydrate amount remedied the hypoglycemia.Type: ApplicationFiled: January 9, 2020Publication date: May 14, 2020Applicants: Roche Diabetes Care, Inc., Roche Diagnostics International AGInventors: Gilles Prodhom, Bernhard Teupe, Alan Greenburg, Maury Zivitz
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Patent number: 10573413Abstract: A method is described herein to detect and treat hypoglycemia. An example of this method involves the detection of hypoglycemia in a patient with a computing device, computation of a recommended carbohydrate amount to ingest by the patient with the computing device in response to said detecting the hypoglycemia, output of the recommended carbohydrate amount with the computing device, and the performance of a hypoglycemia surveillance with the computing device to determine whether the recommended carbohydrate amount remedied the hypoglycemia.Type: GrantFiled: March 14, 2013Date of Patent: February 25, 2020Assignees: Roche Diabetes Care, Inc., Roche Diagnostics International AGInventors: Gilles Prodhom, Bernhard Teupe, Alan Greenburg, Maury Zivitz
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Patent number: 10398853Abstract: Bubble traps for removing bubbles from a stream of liquid and flexible containers comprising such bubble traps are disclosed. The bubble trap includes a containment chamber fluidly coupled to an outlet conduit. At least one grate is disposed between the containment chamber and the outlet conduit. The at least one grate includes a plurality of grate inlets formed in a grate wall and fluidly coupled to the outlet conduit with a plurality of grate conduits such that the containment chamber is fluidly coupled to the outlet conduit. The grate traps bubbles entrained in the stream of liquid flowing from the containment chamber to the outlet conduit in the containment chamber when the bubbles are greater than or equal to a diameter of the grate inlets.Type: GrantFiled: December 12, 2016Date of Patent: September 3, 2019Assignee: Roche Diagnostics International AGInventors: Christoph Huwiler, Florian Kuhni, Andreas Geipel
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Patent number: 10252003Abstract: Embodiments disclosed herein include systems and methods for administering a drug over a time period. One embodiment of a system includes an administration unit, a housing that houses the administration unit, and a controller unit adapted to receive an alarm triggering signal. Also included in some embodiments is an alarming unit that is adapted to generate an alarm signal on reception of the alarm triggering signal. Some embodiments include a patient state monitor that includes a motion-sensitive sensor unit that is reactive on patient motion. The patient state monitor may be adapted to process a sensor signal generated by the motion-sensitive sensor unit. The patient state monitor may also be adapted to transmit the alarm triggering signal to the controller unit if a patient motion level is below a predefined motion level, as determined by a length of time without patient motion.Type: GrantFiled: June 27, 2017Date of Patent: April 9, 2019Assignee: Roche Diagnostics International AGInventors: Wim Van der Helm, Axel Remde, Kurt Friedli
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Patent number: 9889253Abstract: A dosing unit for an infusion pump device is disclosed having a piston pump with a pump cylinder and a plunger arranged within said cylinder, coaxially arranged along a longitudinal axis. The plunger has a shaft with a thread and the cylinder has a threaded sleeve part with a thread. The two threads engaging with each other in such a way that a rotational movement of the plunger around the longitudinal axis results in an additional linear displacement of the plunger along said longitudinal axis. A separate bias force element biases the two threads in regard to each other along the longitudinal axis, such that the threaded engagement of inner thread and outer thread is free of play independent of a direction of a rotational movement and linear displacement of the plunger in regard to the cylinder.Type: GrantFiled: August 15, 2016Date of Patent: February 13, 2018Assignee: Roche Diagnostic International AGInventors: Hanspeter Niklaus, David Teutsch, Ulrich Haueter
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Patent number: 9744295Abstract: An arrangement for introducing a liquid into the body of a patient or for withdrawing a liquid from the body of a patient, including a first structural part carrying a cannula for positioning in the body of the patient, and a second structural part with a connection port for detachably coupling a conduit for supplying or withdrawing a liquid, wherein the first and second structural parts are connected, can be rotated relative to each another and in relative rotational positions form a channel for introducing a liquid from the conduit to the cannula or for withdrawing a liquid from the cannula to the conduit, and whereby movement of the conduit for coupling and uncoupling is transverse to the longitudinal axis of the cannula.Type: GrantFiled: November 23, 2015Date of Patent: August 29, 2017Assignee: Roche Diagnostics International AGInventors: Martin Wyss, Simon Scheuer, Reto Aeschilmann, Christian Thalmann
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Patent number: 9724267Abstract: A container for storing a medical or pharmaceutical liquid comprising a storage compartment for storing the liquid comprising, an inlet opening for filling the storage compartment and an outlet opening for discharging liquid out of the storage compartment is presented. A hydrophilic membrane layer is arranged within the storage compartment which is gas-tight in a wet condition and which at least covers the outlet opening and contacts the liquid stored within the storage compartment. A dosing assembly and a device for automated release of a medical or pharmaceutical liquid comprising and/or capable of using at least one container are also disclosed.Type: GrantFiled: May 15, 2013Date of Patent: August 8, 2017Assignee: Roche Diagnostics International AGInventors: Martin Wyss, Rudolf Zihlmann, Gerald Studer, Andreas Geipel, Davide Crotta
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Publication number: 20170209643Abstract: Micro-fluidic chambers for use in a liquid medicament delivery system, include a bottom substrate and a top cover, the top cover being spaced from the bottom substrate so as to define a height of the chamber, wherein, one or more walls or fillings are positioned in the chamber, the walls or fillings defining a fluid channel there between such that the fluid channel extends from an inlet conduit to an inlet of the chamber to an outlet conduit connected to an outlet of the chamber, wherein, each of the walls or fillings has a height less than the height of the chamber so as to define a fluid gap between a top surface of each wall or filling and the top cover; and wherein, the dimensions of the walls or fillings and the chamber are such that the fluid gap will be filled with liquid by capillary forces via the fluid channel when liquid is introduced into the fluid chamberType: ApplicationFiled: February 14, 2017Publication date: July 27, 2017Applicant: Roche Diagnostics International AGInventors: Andreas Geipel, Christoph Huwiler, Florian Kühni
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Publication number: 20170189611Abstract: A device for inserting an infusion cannula, or sensor, into a patient is presented. The device comprises an insertion needle removable within the infusion cannula, a handle connected to the insertion needle, and a needle cover. The needle cover pivotably mounted on the handle is rotatably movable between a first position, i.e., the front of the insertion needle is in the needle cover, and a second position, i.e., the front is exposed. An infusion site interface comprises a body mounted on a pad attached to the patient; an infusion cannula for inserting into the patient that is connected to the body; a cavity within the body fluidly connected to the cannula; and a septum that seals closed the cavity. The septum is penetrable by an insertion needle in the infusion cannula and by a hollow needle of an infusion tubing connector coupled to the infusion site interface.Type: ApplicationFiled: February 3, 2017Publication date: July 6, 2017Applicant: Roche Diagnostics International AGInventors: Allen John Pearson, James Terence Collins, Neil Alexander Pryor
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Patent number: 9687604Abstract: A dosing device for an infusion system comprises a dosing unit having a variable volume and at least one opening in fluid connection with the variable volume, through which opening the variable volume can be filled with a substance or the substance can be dispensed from the variable volume. The dosing device is operable in a first state for filling the substance from a supply conduit, in a second state for preventing filling and dispensing, or in a third state for dispensing through a dispensing conduit. No direct fluid connection exists between the supply conduit and the dispensing conduit at any time. Methods for dosing a substance with the dosing device.Type: GrantFiled: June 18, 2014Date of Patent: June 27, 2017Assignee: Roche Diagnostics International AGInventors: Ulrich Haueter, Florian Kuehni
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Patent number: 9662453Abstract: At least one dosing unit for an infusion pump is disclosed having a piston pump with a pump cylinder, a plunger arranged within said cylinder, and a plunger driving part provided for transmitting rotational torque from a driving unit to the plunger without itself being linearly displaced. The cylinder, the plunger and the plunger coupling element are coaxially arranged along a longitudinal axis and rotatable around said axis in regard to static parts of the dosing unit. The plunger and cylinder each having threads which engage with each other in such a way that a rotational movement of the plunger around the longitudinal axis results in a linear displacement of the plunger along the longitudinal axis. The dosing unit also having first coupling parts associated with the cylinder and second coupling parts associated with the plunger.Type: GrantFiled: February 28, 2014Date of Patent: May 30, 2017Assignee: Roche Diagnostics International AGInventors: David Teutsch, Martin Wyss, Ulrich Haueter, Simon Scheurer
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Patent number: 9629957Abstract: In one embodiment, an ambulatory insulin infusion system may include an administration module for insulin administration, a data collection module for collecting data relevant for the bolus amount, and a delay module. The administration module may administer insulin continuously according to a basal profile and a bolus on demand. The bolus has a bolus amount. The data collection module may be operatively coupled to the administration module. The delay module may trigger administration of the bolus a therapeutically significant delay interval after the data is collected.Type: GrantFiled: December 16, 2010Date of Patent: April 25, 2017Assignee: Roche Diagnostics International AGInventors: Reto Sigrist, Nicole Bernini, Axel Remde
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Publication number: 20170100305Abstract: An alignment device for coupling a liquid drug cartridge with a longitudinal cartridge axis and a constricted neck portion with a cap and a piercable septum distal from the neck portion with an adapter is presented. The septum is perpendicular to the cartridge axis. The device comprises an adapter cannula with a longitudinal cannula axis to pierce the septum and a proximal cartridge engagement structure for axial aligned engagement with a distal end section of cartridge body. The device further comprises a distal adapter engagement structure for axial aligned engagement with the adapter. A coupling of the cartridge with the adapter is enabled via the alignment device. The adapter and the cartridge are, during the coupling, aligned by the cartridge engagement structure and the adapter engagement structure, respectively relative to each other such that the longitudinal cartridge axis and the longitudinal cannula axis form a common longitudinal axis.Type: ApplicationFiled: December 20, 2016Publication date: April 13, 2017Applicant: Roche Diagnostics International AGInventors: Franco Moia, Pius Kuster, Torsten Kraft, Christoph Walther
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Patent number: 9610400Abstract: A device for moving a piston inside a cartridge having a cartridge body and the piston displaceable along a longitudinal axis of the cartridge body is presented. The device comprises a first portion having first coupler for coupling the cartridge body to the first portion such that in both directions of the longitudinal axis, a connection exists between the cartridge body and the first portion; and a second portion having second coupler for coupling the piston to the second portion such that in both directions of the longitudinal axis, a connection exists between the piston and the second portion. The first and second portions move relative to each other to effect at least a forward displacement of the piston coupled to the second portion inside the cartridge body coupled to the first portion along the longitudinal axis. The second coupler establishes and releases the connection with the piston.Type: GrantFiled: October 9, 2013Date of Patent: April 4, 2017Assignee: ROCHE DIAGNOSTICS INTERNATIONAL AGInventors: Franco Moia, Marcel Mueller, Maurice Ducret
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Patent number: 9603998Abstract: Micro-fluidic chambers for use in a liquid medicament delivery system, include a bottom substrate and a top cover, the top cover being spaced from the bottom substrate so as to define a height of the chamber, wherein, one or more walls or fillings are positioned in the chamber, the walls or fillings defining a fluid channel there between such that the fluid channel extends from an inlet of the chamber to an outlet of the chamber, wherein, each of the walls or fillings has a height less than the height of the chamber so as to define a fluid gap between a top surface of each wall or filling and the top cover; and wherein, the dimensions of the walls or fillings and the chamber are such that the fluid gap will be filled with liquid by capillary forces via the fluid channel when liquid is introduced into the fluid chamber.Type: GrantFiled: September 8, 2010Date of Patent: March 28, 2017Assignee: Roche Diagnostics International AGInventors: Andreas Geipel, Christoph Huwiler, Florian Kühni
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Patent number: 9592338Abstract: A device for inserting an infusion cannula, or sensor, into a patient is presented. The device comprises an insertion needle removable within the infusion cannula, a handle connected to the insertion needle, and a needle cover. The needle cover pivotably mounted on the handle is rotatably movable between a first position, i.e., the front of the insertion needle is in the needle cover, and a second position, i.e., the front is exposed. An infusion site interface comprises a body mounted on a pad attached to the patient; an infusion cannula for inserting into the patient that is connected to the body; a cavity within the body fluidly connected to the cannula; and a septum that seals closed the cavity. The septum is penetrable by an insertion needle in the infusion cannula and by a hollow needle of an infusion tubing connector coupled to the infusion site interface.Type: GrantFiled: December 13, 2012Date of Patent: March 14, 2017Assignee: ROCHE DIAGNOSTICS INTERNATIONAL AGInventors: Allen John Pearson, James Terence Collins, Neil Alexander Pryor
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Patent number: 9579036Abstract: A sensor may include a substrate having a sensing portion defining a sensor thereon and a circuit mounting portion defining at least one electrically conductive pad that is electrically connected to the sensor. The sensor may be configured to produce a signal indicative of a condition of the patient. An anisotropic medium may be disposed on the circuit mounting portion and may be electrically conductive in a direction through the medium and electrically insulating in directions along the medium. An electrical circuit may be mechanically mounted to the circuit mounting portion of the first substrate via the anisotropic medium with at least one electrically conductive terminal juxtaposed over the at least one electrically conductive pad. The anisotropic medium may establish local electrical contact between the at least one electrically conductive terminal and the at least one electrically conductive pad.Type: GrantFiled: January 11, 2013Date of Patent: February 28, 2017Assignees: Roche Diabetes Care, Inc., Roche Diagnostics International AGInventors: Joachim Kasielke, Ulrich Haueter, Ulrike Kamecke, Christian Hof, Matthew Reynolds, Timon Kasielke, Steven Gray, Harvey B Buck, Michael Lukin, Fritz Hindelang
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Patent number: 9555197Abstract: Bubble traps for removing bubbles from a stream of liquid and flexible containers comprising such bubble traps are disclosed. The bubble trap includes a containment chamber fluidly coupled to an outlet conduit. At least one grate is disposed between the containment chamber and the outlet conduit. The at least one grate includes a plurality of grate inlets formed in a grate wall and fluidly coupled to the outlet conduit with a plurality of grate conduits such that the containment chamber is fluidly coupled to the outlet conduit. The grate traps bubbles entrained in the stream of liquid flowing from the containment chamber to the outlet conduit in the containment chamber when the bubbles are greater than or equal to a diameter of the grate inlets.Type: GrantFiled: May 9, 2014Date of Patent: January 31, 2017Assignee: Roche Diagnostics International AGInventors: Christoph Huwiler, Florian Kuhni, Andreas Geipel
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Patent number: 9554967Abstract: An alignment device for coupling a liquid drug cartridge with a longitudinal cartridge axis and a constricted neck portion with a cap and a piercable septum distal from the neck portion with an adapter is presented. The septum is perpendicular to the cartridge axis. The device comprises an adapter cannula with a longitudinal cannula axis to pierce the septum and a proximal cartridge engagement structure for axial aligned engagement with a distal end section of cartridge body. The device further comprises a distal adapter engagement structure for axial aligned engagement with the adapter. A coupling of the cartridge with the adapter is enabled via the alignment device. The adapter and the cartridge are, during the coupling, aligned by the cartridge engagement structure and the adapter engagement structure, respectively relative to each other such that the longitudinal cartridge axis and the longitudinal cannula axis form a common longitudinal axis.Type: GrantFiled: September 23, 2013Date of Patent: January 31, 2017Assignee: ROCHE DIAGNOSTICS INTERNATIONAL AGInventors: Franco Moia, Pius Kuster, Torsten Kraft, Christoph Walther
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Patent number: 9522228Abstract: A soft cannula is inserted into tissue and affixed to skin. A cannula arrangement moves within a housing and provides the soft cannula and a guiding needle extending through the cannula to temporarily stiffen it. A drive effects an insertion movement of the cannula arrangement from a first position, where a puncturing tip is pulled back relative to a face of the housing, into a second position, where the puncturing tip protrudes beyond the face, and automatically effects a retracting movement of the guiding needle into a third position, where the puncturing tip is pulled back relative to the face. The face is formed by a base plate affixed to the housing so that when the cannula arrangement is in the second position, the face detaches from the housing. A holder element is connected to the soft cannula and couples to the base plate in the cannula arrangement's second position.Type: GrantFiled: December 13, 2012Date of Patent: December 20, 2016Assignee: Roche Diagnostics International AGInventors: David Teutsch, Christoph Huwiler, Philipp Michel, Heiner Kaufmann