Abstract: Methods and devices for micro-dosing a liquid are disclosed herein. According to one embodiment, a method for a time controlled micro-dosing of a liquid from a liquid reservoir includes: receiving the liquid reservoir with a structure wherein the structure is portable; securing the liquid reservoir to the structure; connecting a second end of a drive unit to a piston disposed within the liquid reservoir; activating a drive motor; displacing the drive unit with respect to the structure towards the piston in an axial direction with the drive motor; moving the piston axially within the liquid reservoir; and micro-dosing the liquid from the liquid reservoir.

Abstract: According to one embodiment, a medical device may include an energy supply. The energy supply may include a lithium-ion polymer battery including at least two battery stacks and a control unit. One of the at least two battery stacks may be a backup energy source. The control unit may monitor and control the energy supply such that when the control unit detects a fault in the at least two battery stacks, the control unit disconnects a faulty battery stack. The energy supply may be rechargeable. Each of the at least two battery stacks may include a positive potential terminal, a negative potential terminal and one or more battery cell.

Abstract: A device for facilitating the use or application of skin penetrators, the device including a puncturing part for piercing the skin, an indwelling part which can be introduced into the skin through an opening generated by the puncturing part and remains there, wherein the puncturing part and indwelling part are operably associated with the device, and a guide operably associated with the device, wherein, in use, the indwelling part is moved, via the guide, into a position of use after the puncturing part has pierced the skin. In some embodiments, the puncturing and indwelling parts are separate from each other prior to use. A method of using skin penetrators is encompassed and includes sequentially introducing the puncturing part and the indwelling part into the skin.

Abstract: Ampoules for dispensing flowable substances and metering systems incorporating the same are described herein. An ampoule for a flowable substance includes an ampoule body comprising an interior space for receiving the flowable substance and an inner circumferential surface having a guide region and a sealing region. A piston may be disposed in the interior space of the ampoule body such that the piston is slidably displaceable along a direction of displacement. The piston includes at least one sealing element for forming a seal with the inner circumferential surface in a contact zone on the outer circumference of the sealing element. The sealing element has a first compression state when the contact zone is in the guide region and a second compression state when the contact zone is in the sealing region. A second blocking device prevents movement of the contact zone from the sealing region to the guide region.

Abstract: An insulin pump comprises a pump device, a control for the pump device, a memory, an operating element for operating the insulin pump and a method for controlling a user interface of the insulin pump are disclosed. The control is designed and programmed such that options for the user of the insulin pump are displayed by the user interface as a function of a user-specific preference profile stored in the memory and as a function of a current time and are provided for selection by using the operating element. The insulin pump can be designed in an auto-adaptive fashion, such that the control continuously updates the user-specific preference profile based on analyzing operating inputs of the user. Embodiments of the invention allow a large range of functions and simple operation, even in the case of miniaturized pumps.

Abstract: According to one embodiment, a medical device may include an energy supply. The energy supply includes at least two battery stacks, a control unit and a reservoir. The at least two battery stacks include a backup energy source. The control unit may monitor and control the energy supply such that when the control unit detects a fault in the at least two battery stacks, the control unit disconnects a faulty battery stack. The reservoir may be carried by the energy supply.

Abstract: A device for detecting pressure and/or temperature changes in a fluid-channel and method thereof are disclosed. The device includes a main duct with an inlet and an outlet, a branch ductwork with a first branch end branching off the main duct downwards the inlet and with a second branch end discharging into the main duct upwards the outlet, and at least one dead-end channel with a first end that branches off the branch ductwork and a second closed end. The dead-end channel is adapted to trap a gas bubble within the dead-end channel when the device is primed or filled with a liquid fluid, wherein the gas bubble changes its size or position if a change in pressure or temperature occurs in the device.

Abstract: A computer research tool for inputting, searching, displaying, and analyzing metabolic-related clinical data utilizing a novel graphical user interface (GUI) for visual-statistical data analysis and insight generation and method thereof are disclosed.

Abstract: A catheter for connecting an administering device to an administering needle, the catheter including a catheter wall, a flow region limited by the catheter wall, and at least one catheter portion at which at least one partial piece of the catheter wall abuts at least one other partial piece of the catheter wall to releaseably block or obstruct the flow of a medium through the catheter, wherein the flow is unblocked or opened when the medium exhibits a pressure above a predetermined blocking pressure.

Abstract: Cannula assemblies with pressure sensors made of stacked coplanar layers and ambulatory infusion systems comprising the same are disclosed. The cannula assemblies include a hub and an infusion cannula. The hub includes a pressure sensor and a fluid channel fluidly coupled to the infusion cannula. The pressure sensor is formed from a stack of coplanar layers including a top layer, a base layer an electrode layer and a counter electrode layer. The fluid channel is positioned between the top layer and the base layer. The electrode layer is positioned between the top layer and the base layer and coupled to the fluid channel. The counter-electrode layer is positioned between the top layer and the electrode layer. A spacer layer having a through cut-out defining an electrode cavity is disposed between the top layer and the base layer such that the electrode layer extends across the electrode cavity.

Abstract: Included are systems and methods for determining a fill level of an inflow-less flexible medicine reservoir as a source for medicine, where the inflow-less flexible medicine reservoir has a monotonically decreasing fill level. Some embodiments of a device include a stop surface designed and arranged such that the stop surface contacts the inflow-less flexible medicine reservoir while the inflow-less flexible medicine reservoir is filled above a predetermined level. Similarly, some embodiments of the device additionally include a release detector that generates an output signal indicative of contact between the stop surface and the inflow-less flexible medicine reservoir being released and a processing unit for determining the fill level of the inflow-less flexible medicine reservoir from an output signal of the release detector.

Abstract: An ambulatory infusion device for infusion of a liquid drug into a patient's body over an extended period of time and methods thereof are disclosed. The device includes a sensor assembly, which produces a sensor assembly output based on an infusion characteristic of the ambulatory infusion device and based on a supply voltage/current, and a supply unit which is coupled to a sensor of the sensor assembly and generates the supply voltage/current. A sensor testing unit detects a failure of the sensor assembly, wherein the sensor testing unit is coupled to the sensor assembly and the supply unit, and the sensor testing unit carries out a sensor testing sequence. The sensor testing sequence includes controlling the supply unit so as to produce a variation of the supply voltage/current, and determining whether the variation of the supply voltage/current produces a corresponding variation of the sensor assembly output.

Abstract: In one embodiment, a method of filling a container with a liquid drug from a drug reservoir may include: a) connecting a container and a drug reservoir with a cannula such that the drug reservoir and the container fluidically communicate with each other via the cannula, while being hermetically sealed; b) reducing a first volume contained within the container to displace a gaseous medium from the first volume of the container via the cannula into a second volume contained within the drug reservoir; c) increasing the first volume of the container to displace the liquid drug from the second volume of the drug reservoir into the first volume of the container to fill the container; and d) disconnecting the container and the drug reservoir. Before performing action d), action b) and action c) can be successively performed more than once to stepwise increase an amount of liquid drug displaced.

Abstract: Embodiments of an assessment method for processing a signal corresponding to a glucose concentration and performing a retrospective analysis includes the steps of: a) initiating a first trigger, wherein the first trigger defines the beginning of a segment of a continuous measurement of glucose concentration or define the first of a series of spot measurements of glucose concentration; b) collecting data of the continuous measurement or the series of spot measurements of glucose concentration to be analyzed, wherein the collected data relates to a glucose concentration excursion corresponding to a reaction to a relevant event such as a meal or physical activity; c) analyzing the collected data initiated by a second trigger, wherein the second trigger defines the end of the collected data to be analyzed, wherein a measure for a grading of the excursion is determined from the collected data, and d) displaying the result of the analysis.

Abstract: A device for metered administration of a liquid product including a container for the product, a delivery mechanism which acts on the product located in the container and delivers product from the container by means of an axial output movement in a delivery direction, and an inherently axially rigid housing support structure which supports the container in and counter to the delivery direction, wherein the housing support structure has, over the axial length of the container, an axial thermal expansion coefficient which, within a temperature range in which the device is used, corresponds at least substantially to the axial thermal expansion coefficient of the container.

Abstract: An insulin pump comprises a pump device, a control for the pump device, a memory, an operating element for operating the insulin pump and a method for controlling a user interface of the insulin pump are disclosed. The control is designed and programmed such that options for the user of the insulin pump are displayed by the user interface as a function of a user-specific preference profile stored in the memory and as a function of a current time and are provided for selection by using the operating element. The insulin pump can be designed in an auto-adaptive fashion, such that the control continuously updates the user-specific preference profile based on analyzing operating inputs of the user. Embodiments of the invention allow a large range of functions and simple operation, even in the case of miniaturized pumps.

Abstract: A method for manufacturing a structural part with a cannula for the subcutaneous administration of an active substance is disclosed. A loose cannula is threaded on a piercing means to form a ready-to-use cannula piercing unit and subsequently, a cannula housing is injection-molded onto the cannula. Embodiments for the cannula as well as the structural part, an application part, an insertion head, and an insertion device which includes the cannula are also disclosed.

Abstract: Cannula assemblies with pressure sensors made of stacked coplanar layers and ambulatory infusion systems comprising the same are disclosed. The cannula assemblies include a hub and an infusion cannula. The hub includes a pressure sensor and a fluid channel fluidly coupled to the infusion cannula. The pressure sensor is formed from a stack of coplanar layers including a top layer, a base layer an electrode layer and a counter electrode layer. The fluid channel is positioned between the top layer and the base layer. The electrode layer is positioned between the top layer and the base layer and coupled to the fluid channel. The counter-electrode layer is positioned between the top layer and the electrode layer. A spacer layer having a through cut-out defining an electrode cavity is disposed between the top layer and the base layer such that the electrode layer extends across the electrode cavity.

Abstract: Included are systems and methods for determining a fill level of an inflow-less flexible medicine reservoir as a source for medicine, where the inflow-less flexible medicine reservoir has a monotonically decreasing fill level. Some embodiments of a device include a stop surface designed and arranged such that the stop surface contacts the inflow-less flexible medicine reservoir while the inflow-less flexible medicine reservoir is filled above a predetermined level. Similarly, some embodiments of the device additionally include a release detector that generates an output signal indicative of contact between the stop surface and the inflow-less flexible medicine reservoir being released and a processing unit for determining the fill level of the inflow-less flexible medicine reservoir from an output signal of the release detector.

Abstract: In a method for visualization of a parameter which is measured continuously on or in a human body, in particular a glucose concentration, the following steps are carried out. First, a measured value range for a measured parameter is subdivided into two or more sub-ranges. Trend information is then calculated relating to the future expected profile of the measured parameter on the basis of two or more measured values. A time period after which it is predicted that the measured parameter will have left its current sub-range is calculated based on current value of the measured parameter and the calculated trend information and finally the time period is displayed.