Patents Assigned to Roche Diagnostics Operations, Inc.
  • Publication number: 20210373042
    Abstract: A module for an automated laboratory system is disclosed. The module comprises a module connector configured to releasably connect to a component of the automated laboratory system, a detector at least configured to detect at least one component marker located at the component so as to obtain position data of the module indicating an actual position of the module, a processor configured to calculate a position deviation of the module from a target position defined by the component based on the position data and to calculate position alignment data based on the position deviation, and a alignment device configured to align the module to the target position based on the position alignment data. Further, an automated laboratory system and a method for aligning a module are disclosed.
    Type: Application
    Filed: May 24, 2021
    Publication date: December 2, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Ivan Heinzer
  • Patent number: 11187709
    Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: November 30, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Sascha Antoni, Christian Vogl
  • Publication number: 20210364283
    Abstract: An apparatus for measuring an angle between a longitudinal axis of a sample container inserted into an opening of a sample container carrier and a reference ray, the apparatus comprising a first accelerometer being fixable to the sample container and being adapted to generate a number of first accelerometer signals being dependent on the orientation of the sample container, and a calculation unit being coupled to the first accelerometer and being adapted to calculate the angle depending on the number of first accelerometer signals.
    Type: Application
    Filed: May 12, 2021
    Publication date: November 25, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Richard-Paul Daisley
  • Publication number: 20210364540
    Abstract: A laboratory sample container carrier cleaning apparatus is provided comprising a revolving device, being adapted to move a sample container carrier supplied to the revolving device along a circular path, and a cleaning device, being adapted to clean the sample container carrier being moved along the circular path.
    Type: Application
    Filed: May 11, 2021
    Publication date: November 25, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Christopher William Bates
  • Patent number: 11175301
    Abstract: An automatic analyzer includes: a reagent mounting unit 103 in which a plurality of reagent bottles 10 are installed when a reagent bottle 10 is loaded into the automatic analyzer; a reagent conveying mechanism 101 including a gripper mechanism 106; and a reagent mounting mechanism 102 for moving the reagent mounting unit 103 between an installation position at which an operator installs the reagent bottle 10 in the reagent mounting unit 103 and a position at which the gripper mechanism 106 grips the reagent bottle 10. It is thereby possible to achieve saving of a mechanism installation space and reduction of the number of constituent components, automatically carry out an operation from opening of the reagent bottle to loading of the reagent bottle into the reagent disk, and alleviate an operator's burden.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: November 16, 2021
    Assignees: HITACHI HIGH-TECH CORPORATION, ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Takamichi Mori, Kouhei Nonaka, Masaki Hara, Masato Ishizawa, Hitoshi Tokieda, Stephan Sattler
  • Publication number: 20210349049
    Abstract: A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.
    Type: Application
    Filed: July 23, 2021
    Publication date: November 11, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Michael Marquant, Samuel Evgin, Melanie Klein
  • Publication number: 20210349090
    Abstract: The present description relates to a Corona antigen having a Corona nucleocapsid specific amino acid sequence, compositions, and reagent kits having the same and methods of producing it. Also encompassed are methods of detecting anti-Corona antibodies in samples using the Corona antigen, and methods of differential diagnosis of an immune response in a patient due to natural Corona infection or due to vaccination against Corona.
    Type: Application
    Filed: May 6, 2020
    Publication date: November 11, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Alexander Riedel, Christian Scholz, Peter Muench, Juliane Benz, Markus Eckl, Frederik Baumkoetter
  • Patent number: 11169169
    Abstract: A method of washing an aspiration probe of an in-vitro diagnostic system is disclosed. The aspiration probe comprises an outer surface and an inner surface forming an inner space for receiving a fluid. The method comprises dipping the aspiration probe into a first wash fluid so that the outer surface is immersed at least in part into the first wash fluid, aspirating an amount of the first wash fluid into the inner space of the aspiration probe, propagating an ultrasonic vibration to the outer surface of the aspiration probe via the first wash fluid, and rinsing the outer surface and the inner surface of the aspiration probe with a second wash fluid. Further, an in-vitro diagnostic method and an in-vitro diagnostic system are disclosed.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: November 9, 2021
    Assignees: ROCHE DIAGNOSTICS OPERATIONS, INC., HITACHI HIGH-TECH CORPORATION
    Inventors: Kouhei Nonaka, Takamichi Mori, Yoichi Aruga, Yosuke Horie, Andrew McCaughey, Alexander Seiler
  • Patent number: 11167430
    Abstract: A gripping device for handling sample containers is presented. The gripping device comprises a number of rigid fingers having non-gripping surfaces adapted to reduce adhesion between the non-gripping surfaces and labels. The number of rigid fingers collectively grip a sample container. Each finger comprises a gripping surface to contact the sample container while the sample container is gripped by the gripping device. The non-gripping surface of each finger is different from the gripping surface. The non-gripping surface of at least one of the fingers is at least partially corrugated. A sample container processing system comprising such a gripping device is also presented.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: November 9, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Jean-Claude Metzger, Thomas Meyer
  • Patent number: 11169061
    Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid containing the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: November 9, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic
  • Publication number: 20210341505
    Abstract: The present disclosure relates to a laboratory container storage system, a laboratory system comprising the laboratory container storage system, and a method of operating the laboratory system. The laboratory container storage system comprising one or more laboratory container storage devices. Each laboratory container storage device comprises a frame and a storage element comprising a holder configured to receive and release a laboratory container horizontally and to hold the laboratory container in a suspended position above a horizontal surface. The storage element is mounted movably on the frame and configured to be moved between a first transfer position and a storage position and between the storage position and a second transfer position. In the first and second transfer position, the holder is positioned to receive or release the laboratory container horizontally. The storage position is located between the first and second transfer position.
    Type: Application
    Filed: April 26, 2021
    Publication date: November 4, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Norbert Schmitt, Chris Steinert
  • Publication number: 20210333297
    Abstract: A laboratory sample vessel distribution system is presented. The system comprises a cabinet, sample vessel carriers for receiving sample vessels, and a cabinet drawer for receiving a sample vessel carrier. The drawer is locatable in different positions: closed, opened, and fully opened. An actuator moves the sample vessels and the sample vessel carriers between different locations. An actuator driver drives the actuator and applies a first mode of operation with a first speed and a second mode of operation with a second reduced speed compared to the first speed. A sensor device detects between opened and closed positions and provides position signals. A control device is connected to the actuator driver and the sensor device. The control device provides control signals to the actuator driver instructing the actuator driver to apply either the first mode, if in the closed position, or the second mode, if in the opened position.
    Type: Application
    Filed: April 16, 2021
    Publication date: October 28, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Andreas Schesny, Vladimirs Leontjevs
  • Publication number: 20210333277
    Abstract: The present invention relates to a Corona antigen comprising a Corona nucleocapsid specific amino acid sequence, compositions, and reagent kits comprising the same and methods of producing it. Also encompassed are methods of detecting anti-Corona antibodies in samples using said Corona antigen, and methods of differential diagnosis of an immune response in a patient due to natural Corona infection or due to vaccination against Corona.
    Type: Application
    Filed: April 23, 2020
    Publication date: October 28, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Alexander Riedel, Christian Scholz, Peter Muench, Juliane Benz, Markus Eckl, Frederik Baumkoetter
  • Patent number: 11156610
    Abstract: Described is a method for determining an analyte in a sample suspected to contain the analyte, by a) contacting the sample with a first and a second capture compound for the analyte, wherein the first and second capture compounds are non-identical capture compounds, and the capture compounds compete in binding to the analyte; b) contacting the capture compounds contacted with the sample with a specifier, wherein the specifier competes in binding to the capture compounds with the analyte; c) determining the amount of complexes having the specifier and a capture compound; and d) determining the analyte in a sample based on the result of step c). Also disclosed is a method for improving the specificity of an indirect immunoassay for determining an analyte, as well as kits, devices, and uses related to the methods.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: October 26, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Barbara Upmeier, Toralf Zarnt, Johannes Polz
  • Patent number: 11150256
    Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: October 19, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Friedrich Ackermann, Andreas Calatzis, Rik Harbers, Roland Hutter, Jean-Pierre Bolliger, Theresa Kitcoff, Patrick Sascha Labud
  • Patent number: 11150247
    Abstract: The present disclosure relates to a method for detecting a core polypeptide of a hepatitis C virus (HCV) in a sample from a subject involving (a) contacting said sample with a base and with a surfactant having a cationic detergent, and (b) detecting a core polypeptide of the HCV in the sample. The present invention further relates to a method for pre-processing a sample from a subject for detection of HCV, involving contacting the sample with a base and with a surfactant having a cationic detergent; and to a pre-processing reagent for detecting HCV in a sample, having a base and a surfactant including a cationic detergent, wherein the surfactant also has a nonionic detergent. Moreover, the present disclosure further relates to kits, uses, and devices related to the methods disclosed.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: October 19, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ralf Bollhagen, Barbara Upmeier, Toralf Zarnt, Peter Muench, Manfred Ginter
  • Publication number: 20210311083
    Abstract: A sample handling system for handling samples is disclosed. The sample handling system comprises sample holders, each receives a sample container; a sample transport device for moving the sample holders; a control unit for controlling functionality of the sample handling system, and a monitoring system for monitoring the samples during movement. The monitoring system comprises a camera module for continuously capturing images of a part of the sample transport device, wherein the camera module is at a distance from the sample transport device such that the camera module has a free field of view to the sample transport device, and a processor for processing the captured images and determining an item of information about the sample transport device and/or the sample container and/or the sample from the captured images. The control unit retrieves the item of information from the processor. The controlling is based on the retrieved item of information.
    Type: Application
    Filed: March 31, 2021
    Publication date: October 7, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Christopher Espy, Yin Cai
  • Patent number: 11136376
    Abstract: The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: October 5, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Alfred Engel, Pavel Kubalec, Alfons Nichtl, Tobias Oelschlaegel, Rainer Schlecht
  • Patent number: D933828
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: October 19, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Johann Florian Wassermann, Roman Gebhard, Samuel Coendet
  • Patent number: D934417
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: October 26, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Thomas Z. Harkin