Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

Abstract: A healthcare data system. The system comprises a data protection entity configured to: sign at least a portion of a routing header of a data packet with a private key held by the data protection entity, the data packet including a payload and a routing header, the payload including healthcare data and the routing header indicating an intended consumer of the data packet; and transmit the data packet on towards the intended consumer. The healthcare data system further comprises one or more data receivers, each configured to: receive the data packet; and verify the signed routing header.

Abstract: A computer-implemented method of detecting the presence of morphologically abnormal cells in a specimen image comprises: receiving electronic image data representative of a specimen image, the specimen image depicting a plurality of cells; applying an analytical model to each of a plurality of subsets of the image data, each subset corresponding to a respective portion of the specimen image which depicts a single cell, the analytical model configured to output, for each subset of the image data: a value parameterizing a property of the cell; and either a confidence score or an uncertainty score associated with the value, thereby generating output data comprising the plurality of confidence scores or plurality of uncertainty scores; and determining, based on the output data, whether one or more morphologically abnormal cells are likely to be present in the specimen image.

Abstract: The present disclosure relates to a laboratory sample container carrier handling apparatus comprising a revolving device, being adapted to move a sample container carrier supplied to the revolving device along a circular path P, and wherein the circular path P has at least one ascending ramp. The present disclosure relates further to a laboratory sample distribution system comprising such a laboratory sample container carrier handling apparatus.

Abstract: A computer implemented method for a data sharing system to share healthcare data from a healthcare data provider with a healthcare data processing application. The method includes identifying one or more healthcare data processor applications, generating and displaying selectable options of the one or more data processor applications at a healthcare data provider, obtaining a selection of the one or more data processor applications from the healthcare data provider, obtaining a data provider/application-specific encryption keyset corresponding to each selected healthcare data processor application, the keyset comprising a private key and a public key, retaining the private key of the data provider/application-specific keyset with a trusted component of the healthcare data provider, and sharing the public key of the data provider/application-specific keyset with the corresponding selected healthcare data processor application.

Abstract: Provided are methods, compositions, and systems for the detection of a target analyte. Also provided are methods, compositions, and systems for determining the concentration one or more target analytes in fluid solution. The compositions include nanopore conjugates in which a nanopore protein monomer is joined to a capture tag. Tethered to the nanopore protein conjugate is an analyte ligand directed to a specific analyte. When a voltage is applied across a nanopore assembly including the nanopore conjugate, the nanopore captures the capture tag at a given capture rate. In the presence of the analyte to the analyte ligand, however, the capture rate of the capture tag changes, thus permitting detection of the analyte by the nanopore assembly. Further, based on the capture rate associated with binding between the analyte and the analyte ligand, the concentration of the analyte can be determined using association/dissociation kinetics.

Abstract: The present invention relates to methods of assessing whether a patient has endometriosis or is at risk of developing endometriosis, to methods of selecting a patient for therapy, and method of monitoring a patient suffering from endometriosis or being treated for endometriosis by determining the amount or concentration of S100A8 in a sample of the patient, and comparing the determined amount or concentration to a reference.

Abstract: A point of care testing (POCT) instrument for analyzing biological samples and a POCT system comprising a plurality of such POCT instruments is proposed. The POCT instrument comprises a housing, a measurement unit designed for collecting data indicative of at least one biological parameter of a biological sample, a main display, and an auxiliary display.

Abstract: A method for identifying and/or verifying at least one analyte peak in a chromatogram of a sample for said analyte from a liquid chromatography mass spectrometer device, said method comprising: a) determining a chromatogram of the sample by acquiring a plurality of data points for quantifier signal intensities and/or qualifier signal intensities, over time; and, in case the sample comprises an internal standard, optionally acquiring a plurality of data points for internal standard quantifier signal intensities and/or internal standard qualifier signal intensities, over time; b) determining for at least a fraction of the data points acquired in step a), a ratio type; c) comparing the ratios determined in step b) to a reference; and d) identifying and/or verifying at least one analyte peak in a chromatogram based on comparison step c).

Abstract: A computer-implemented method of automatic registration of a device in a laboratory system comprising: transmitting from the to be registered device specific information to a managing unit (“unit”) via a first interface; the unit requesting a solution specific configuration from a remote infrastructure via a second interface, receiving the solution specific configuration from the remote infrastructure via the second interface, and transmitting the solution specific configuration to the device to be registered via the first interface, the solution specific configuration being based on the device specific information and configuration information about the laboratory system; and transmitting a request from the unit comprising updated solution specific configuration to the laboratory devices, the updated solution specific configuration comprising information about the device to be registered and changes due to addition of said device, wherein the laboratory configuration step comprising providing the updated

Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.

Abstract: The present disclosure relates to a laboratory container storage system, a laboratory system comprising the laboratory container storage system, and a method of operating the laboratory system. The laboratory container storage system comprising one or more laboratory container storage devices. Each laboratory container storage device comprises a frame and a storage element comprising a holder configured to receive and release a laboratory container horizontally and to hold the laboratory container in a suspended position above a horizontal surface. The storage element is mounted movably on the frame and configured to be moved between a first transfer position and a storage position and between the storage position and a second transfer position. In the first and second transfer position, the holder is positioned to receive or release the laboratory container horizontally. The storage position is located between the first and second transfer position.

Abstract: A laboratory sample container carrier handling apparatus is provided comprising a revolving device, a guiding surface, and a force-applying device, wherein the force-applying device is adapted to apply a force to a laboratory sample container carrier supplied to the revolving device to such an extent that the laboratory sample container carrier is forced against the guiding surface to such an extent that the laboratory sample container carrier rolls off at the guiding surface pushed by the revolving device. A laboratory automation system is also provided comprising such a laboratory sample container carrier handling apparatus and to a use of such a laboratory sample container carrier handling apparatus for handling a laboratory sample container carrier in, in particular such, a laboratory automation system.

Abstract: The present disclosure deals with the biochemistry of reagents useful in the detection of ammonia in liquid samples. Specifically, the present disclosure is directed to a technical improvement of an enzyme-based test for ammonia that can be used for analysis of plasma samples taken from patients in clinical settings, among other uses. In this regard, stability of a reagent containing NAD(P)H is improved, enhancing shelf life and results in the detection of ammonia. In an exemplary reagent ammonia released as a result of NAD(P)H decay is scavenged using an enzymatic reaction to convert the ammonia using GLDH, NAD(P)H and 2-oxoglutarate, thereby forming L-glutamate, NAD(P)+ and H2O in the NAD(P)H containing reagent.

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

Abstract: A column device for an automatic analyser. The automatic analyzer comprises a high performance liquid chromatography (HPLC) module. The HPLC module comprises a fixation device configured to automatically fix and release a chromatographic column. The column device comprises a column jacket and a capillary. The capillary comprises predetermined dimensions and is disposed within the column jacket. The column device is configured to be installed at the HPLC module using the fixation device. Further, an automatic analyzer is disclosed.

Abstract: A computer implemented method of a design enterprise network for facilitating remote configuration of a software instance comprised in a laboratory enterprise network, wherein the laboratory enterprise network is communicably coupled to an in vitro diagnostics (IVD) network, wherein the IVD network comprises at least one IVD instrument, and wherein the computer implemented method comprises obtaining by a generator computing instance comprised in a design enterprise network, a configuration definition input for configuring the software instance and generating, by the generator computing instance comprised in the design enterprise network, a configuration object based on the configuration definition input.

Abstract: The automatic analyzer includes: an analyzing unit that analyzes a sample; and a control device that controls operation of each mechanism of the analyzing unit. The control device calculates waiting time for which a user must wait before replacing the sample or a consumable necessary for analyzing the sample based on time when the sample or the consumable is last used in an analysis schedule that has been created at a point when the control device receives a replacement request for the sample or the consumable. It can be to provide an automatic analyzer capable of improving work efficiency, and a method for operating the automatic analyzer.

Abstract: A healthcare system for providing medical insights by receiving medically relevant data (MRD) and providing results of medical algorithms using the medically relevant data (MRD), the medically relevant data (MRD) comprising quantitative medical data created based on at least one diagnostic measurement method, wherein the healthcare system comprises two or more medical algorithm modules and a service module, and the functionalities are separated between the medical algorithm modules and the service module.

Abstract: This disclosure relates generally to the use of automated platforms in the preparation of biomarker-stained cellular samples for microscopic analysis and use of such stained cells in the diagnosis of certain conditions. Disclosed herein is a method of affinity staining a Romanowsky-type stained sample on automated advanced staining systems, wherein the automated advanced stainer destains the sample prior to contact with a biomarker-specific reagent. Also disclosed herein are methods of processing body fluid samples for morphological and biomarker analysis by depositing cells of the sample in a thin layer onto one or more solid supports, staining at least one such solid support with a Romanowsky-type stain and staining at least one such solid support for one or more biomarkers useful for categorizing one or more cells of the sample.