Patents Assigned to Roche Diagnostics Operations, Inc.
  • Publication number: 20220373379
    Abstract: An apparatus for determining a vertical position of at least one interface between a first component and at least one second component, the components comprised as different layers in a sample container. The apparatus comprises a first sensing unit and a first light detector configured to generate a first sensing signal, a second sensing unit comprising a second light detector configured to generate a second sensing signal, a driving unit configured to move the sample container, a position sensing unit configured to output a position sensing signal indicative of a vertical position of the sample container, a vertical position determining unit configured to match the first and the second sensing signal such that first and the second sensing signal correspond to identical vertical positions, and to determine the vertical position of the at least one interface in response to the matched sensing signals and the position sensing signal.
    Type: Application
    Filed: April 27, 2022
    Publication date: November 24, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Christopher Espy
  • Publication number: 20220371828
    Abstract: The present disclosure relates to a method and a distribution system to move carriers on a transport plane. The distribution system comprises at least one first carrier and at least one second carrier, a transport plane comprising a number of moving positions, a drive device adapted to move each carrier to the moving positions, and a control device adapted to control the drive device. The control device plans moves for each carrier, checks the planned moves and plans new moves if required before the carriers are moved on the transport plane.
    Type: Application
    Filed: May 20, 2022
    Publication date: November 24, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Edwin Oosterbroek, Nicolas Seungoon Sillitoe
  • Publication number: 20220371020
    Abstract: The present disclosure relates to a laboratory sample container carrier handling apparatus comprising a revolving device, being adapted to move a sample container carrier supplied to the revolving device along a circular path P, and wherein the circular path P has at least one ascending ramp. The present disclosure relates further to a laboratory sample distribution system comprising such a laboratory sample container carrier handling apparatus.
    Type: Application
    Filed: April 26, 2022
    Publication date: November 24, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Avinash Addihalli Narayana, Tobias Huber
  • Patent number: 11509630
    Abstract: A system for providing cyber protection to medical devices in a medical environment is presented. The system comprises a medical device comprising software services, a backend server to maintain and provide software updates to medical devices, and an interface proxy box connected to the medical device and in communication with the backend server. The interface proxy box determines the software services resident on the medical device. The interface proxy box installs the software services determined to be resident on the medical device on the interface proxy box and configures the installed software services to match the software services resident on the medical device. The interface proxy box communicates periodically with the backend server and receives and applies security updates to the software services installed and configured on the interface proxy box. The medical device utilizes the updated software services on the interface proxy box.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: November 22, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Richard Edward Salin, Alejandro Morcillo Montejo
  • Publication number: 20220355303
    Abstract: A preanalytic system is disclosed. The preanalytic system comprises a cap gripper configured to grip a cap of a laboratory sample container, wherein the cap is connected to a rod of a swab located within the laboratory sample container, wherein the cap gripper is further configured to release the cap from the laboratory sample container, and a cutting device configured to cut the rod of the swab when the cap is in a position released from the laboratory sample container.
    Type: Application
    Filed: April 22, 2022
    Publication date: November 10, 2022
    Applicant: Roche Diagnostics Operations, Inc
    Inventors: Angelos Chotzidis, Stefan Soentges, Hans van Mierlo
  • Patent number: 11491236
    Abstract: The present disclosure is directed at an antibody conjugate having an antibody and a tag, wherein one or more element(s) present in the antibody exhibit an isotope ratio which differs from the naturally occurring isotope ratio of the one or more element(s), wherein the amount of the isotope which is less-common in nature, is increased to at least 4% of the atoms of the respective element in the antibody, as well as uses thereof.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: November 8, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Harmut Duefel, Uwe Kobold, Andreas Leinenbach
  • Publication number: 20220349863
    Abstract: A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.
    Type: Application
    Filed: April 19, 2022
    Publication date: November 3, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Andreas Leinenbach, Aart Pieter van Doom
  • Publication number: 20220334141
    Abstract: A method for classifying an identification tag on a sample tube containing a sample to be processed in an automated laboratory system having a plurality of laboratory devices, the method comprising providing a sample tube having an identification tag and containing a sample to be analyzed . Each of the plurality of laboratory devices is assigned a tag reader device configured to read the identification tag for recognizing identification tag information. Further, an automated laboratory system for processing a sample tube containing a sample for at least one of pre-analytics and sample analysis is provided.
    Type: Application
    Filed: April 12, 2022
    Publication date: October 20, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: René Henri Monnard
  • Patent number: 11473118
    Abstract: A method of detecting at least one analyte in a test sample is provided comprising a) contacting the test sample (i) to an active chemistry matrix changing at least one electrochemical property dependent on an enzymatic activity active in the presence of the analyte, the active chemistry matrix contacting a first electrode; and (ii) to an inactive chemistry matrix, the inactive chemistry matrix contacting a second electrode, b) closing an electrical circuit including the first electrode, the second electrode, and the active chemistry matrix and inactive chemistry matrix, followed by determining a first value of the at least one electrochemical property, c) inverting electrical polarity of the electrical circuit of b), followed by determining a second value of the at least one electrochemical property, and d) detecting the at least one analyte based on the first value and on the second value.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: October 18, 2022
    Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Michael Marquant, Michael Reinhardt
  • Publication number: 20220328295
    Abstract: Systems for analyzing a biological sample include a separation unit configured to separate a component from the biological sample, an ionization unit configured to generate a plurality of ions from the component, an adjustable mass-selective filtering element, a detector configured to detect ions that pass through the mass-selective filtering element, and a controller connected to the mass-selective filtering element and to the detector, where the controller is configured so that during operation of the system, the controller adjusts the mass-selective filtering element and activates the detector to measure at least three different ion signals corresponding to the plurality of ions, and determines a mass axis shift of the system based on the at least three different ion signals.
    Type: Application
    Filed: June 29, 2022
    Publication date: October 13, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Nadja Arens, Daniel Intelmann
  • Publication number: 20220328144
    Abstract: A method for delivering medical samples with a laboratory request from an extraction point to a laboratory is presented. The availability of the test to be performed on a sample during a time at a first laboratory is checked. If the test cannot be performed during that time, laboratory attributes available at laboratories are checked via laboratory broker devices. A suitable candidate laboratory can be identified amongst the laboratories based on the laboratory attributes of the suitable candidate laboratory. The identified suitable candidate laboratory and the first laboratory communicate with each other regarding the feasibility of the suitable candidate laboratory to perform the test on the sample. If feasible to perform the test at the suitable candidate laboratory, the sample and the laboratory request are delivered to the suitable candidate laboratory for testing. After test performance at the suitable candidate laboratory, the test results are communicated to the extraction point.
    Type: Application
    Filed: April 4, 2022
    Publication date: October 13, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Hector Cormano Bel, Janne-Henrik Paerssinen, Werner Vercammen, Nuno Miguel Vieira Pedroso, Mario Villace Diez
  • Patent number: 11466098
    Abstract: The present disclosure relates to specific binding agents binding to different PIVKA-II forms as compared to antibodies known so far in the art. The present disclosure also relates to methods of using the specific binding agents to detect the presence of PIVKA-II.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: October 11, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Bernhard Eckert, Michael Gerg, Johann Karl, Martin Kaufmann, Julia Riedlinger, Magdelena Swiatek-de Lange, Lars Hillringhaus, Klaus Hirzel, Marcus-Rene Lisy
  • Publication number: 20220319827
    Abstract: A method for multiple transition monitoring of at least one analyte in a sample using a quadrupole mass analyzer is provided and comprises at least one voltage application step, wherein a direct current (DC) voltage and a radio frequency (AC) voltage are applied between two pairs of electrodes of at least one mass filter of the analyzer, wherein the AC voltage has an amplitude VAC and the DC voltage has an applicable voltage VDC, wherein a supplementary AC voltage is superimposed on top of the AC and the DC voltage, wherein an amplitude ?VDC of the supplementary AC voltage is ? V DC , max 2 b + 1 , wherein VDC,max is a maximum voltage output of the DC voltage and b is a bit size of at least one electronics board of the mass filter of the analyzer; and wherein at least one transition of the analyte is determined with at least one detector of the analyzer.
    Type: Application
    Filed: June 6, 2022
    Publication date: October 6, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan QUINT, Florian SCHWEINBERGER, Benjamin TIEMANN
  • Patent number: 11460474
    Abstract: The present disclosure is directed to a method of identifying a patient having heart failure as likely to respond to a therapy with a statin. The method is based on measuring the level of at least one marker selected from GDF-15 (Growth Differentiation Factor 15), Urea, SHBG (Sex Hormone-Binding Globulin), Uric acid, PLGF (Placental Growth Factor), IL-6 (Interleukin-6), Transferrin, a cardiac Troponin, sFlt-1 (Soluble fms-like tyrosine kinase-1), Prealbumin, Ferritin, Osteopontin, sST2 (soluble ST2), and hsCRP (high sensitivity C-reactive protein) in a sample from a patient. Further envisaged is a method of predicting the risk of a patient to suffer from death or hospitalization, wherein the patient has heart failure and undergoes a therapy with a statin. The method is also based on the measurement of the level of at least one of the aforementioned markers.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: October 4, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Dirk Block, Hanspeter Brunner, Thomas Dieterle, Ursula-Henrike Wienhues-Thelen, Christian Zaugg, Andre Ziegler
  • Patent number: 11459556
    Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: October 4, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Werner Hoelke, Michaela Fischer, Johann-Peter Thalhofer, Markus Weber
  • Publication number: 20220308024
    Abstract: A method for calibrating at least one analytic device with repeated hardware components is disclosed and comprises providing at least one calibrator sample i having a known target value of a concentration of at least one analyte; at least one measuring step, wherein the measuring step comprises conducting at least one measurement on the calibrator sample using the analytic device, wherein at least one detector signal sijk is acquired; at least one calibration step, wherein a relationship between the detector signal and the concentration of the analyte and/or between the detector signal and a theoretical signal value is determined, wherein the calibration step comprises providing at least one parametrized function; determining calibration values by conducting a calibration based on the parametrized function; and determining an analysis function on basis of an inverse of the parametrized function and the determined calibration values.
    Type: Application
    Filed: June 14, 2022
    Publication date: September 29, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Nadja Arens, Andrea Geistanger, Anton Hilger, Daniel Intelmann, Shirin Shahriari
  • Publication number: 20220305766
    Abstract: A method of producing a plurality of analytical test strips using a reel-to-reel process, comprising providing at least one continuous first layer web, having disposed on a first side at least one first electrode layer, the first layer web having a first layer edge; continuously disposing at least one continuous spacer layer web onto the first side of the first layer web, wherein the spacer layer web has a spacer layer edge, wherein the disposing is position-controlled in a master-slave fashion by using a position of the first layer edge as a master position and a position of the spacer layer edge as a slave position; and continuously disposing at least one continuous second layer web onto the spacer layer web, the second layer web having disposed on a first side at least one second electrode layer, wherein the second layer web has a second layer edge.
    Type: Application
    Filed: June 14, 2022
    Publication date: September 29, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Andreas Detloff, Egon Humbek, Artur Letkemann
  • Patent number: 11454615
    Abstract: A liquid chromatographic (LC) system and a method of exchanging a liquid in an LC system are disclosed. The LC system includes an LC pump with at least one pump head having a primary and a secondary pump head, each with a syringe-like cylinder body having an inner wall surface and a plunger translatable through the cylinder body leaving an interspace between the inner wall surface and the plunger when the plunger is translated through the cylinder body, an upstream inlet valve configured to allow liquid into the cylinder body and a downstream outlet valve configured to allow liquid out of the cylinder body. The LC system further includes at least one liquid-exchange pump connected either to the upstream inlet valve of the primary pump head or to the downstream outlet valve of the secondary pump head.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: September 27, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Adrian Sievers-Engler
  • Patent number: 11454634
    Abstract: The present invention relates to a method for assessing whether a subject shall be subjected to an imaging based diagnostic assessment. The method is based on the determination of the amount(s) of a cardiac Troponin and/or Fibroblast Growth Factor 23 (FGF-23) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). The present invention also relates to a system for performing an assessment whether a subject shall be subjected to an imaging based diagnostic assessment and to reagents and kits used in performing the methods disclosed herein. Moreover, the present invention is directed to a method for predicting the risk of mortality and/or of a cardiovascular event. Also encompassed is a method for diagnosing an early stage of LVH in a subject having a preserved left ventricular ejection.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: September 27, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Dirk Block, Roberto Latini, Serge Masson, Ursula-Henrike Wienhues-Thelen, Christian Zaugg
  • Publication number: 20220299538
    Abstract: Apparatus for removing a cap closing a laboratory sample container, the apparatus comprising a cap gripper being adapted to grip a cap to be removed and being adapted to remove the cap being gripped from the laboratory sample container, a displaceable chute comprising a cap inlet, a linear guide defining a linear trajectory, wherein the displaceable chute is mechanically coupled to the linear guide such that the displaceable chute is displaceable along the linear trajectory, and a drive being adapted to cause a displacement of the displaceable chute along the linear trajectory to a dropping position, wherein in the dropping position the removed cap being gripped by the cap gripper is at least partially inserted into the cap inlet of the displaceable chute.
    Type: Application
    Filed: February 25, 2022
    Publication date: September 22, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Marius Kraetschmer