Patents Assigned to Roche Diagnostics Operations, Inc.
  • Patent number: 11946938
    Abstract: The present disclosure demonstrates a method for predicting the risk of stroke of a subject and a method for improving the prediction accuracy of a clinical stroke risk score. The methods are based on the determination of the amount of Angiopoietin-2 (Ang-2) and/or the amount of Insulin-like growth factor-binding protein 7 (IGFBP7) in a sample from a subject. Moreover, disclose is the use of i) the biomarker Ang-2 and/or the biomarker IGFBP7, and/or ii) at least one detection agent that specifically binds to Ang-2 and/or at least one detection agent that specifically binds to IGFBP7 in a sample from a subject for predicting the risk of stroke of said subject.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: April 2, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ursula-Henrike Wienhues-Thelen, Johann Karl, Peter Kastner, Vinzent Rolny, Andre Ziegler, David Conen
  • Patent number: 11947344
    Abstract: A computer implemented method of operating a diagnostic instrument such that maintenance processes do not conflict with operator activity is presented. A maintenance process conflicts with operator activity if the probability of use of the diagnostic instrument is above a usage probability threshold. The probability of use of the diagnostic instrument is determined based on detected presence and/or movement of an operator in the proximity of the diagnostic instrument and/or operation of the diagnostic instrument.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: April 2, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christopher Bradbury, Scott Perala
  • Patent number: 11940427
    Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: March 26, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Benjamin Tiemann, Stefan Quint, Florian Schweinberger
  • Patent number: 11940455
    Abstract: A consumable management system comprising a consumable storage cluster with a plurality of storage compartments is presented. Each storage compartment is configured to receive one or more consumables. The consumable management system further comprises storage compartment indicators to provide guidance to a user and a detection unit for validating user action(s).
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: March 26, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Urs Suter, Riccardo Leone Benedetti, Gregor Hotz, Oliver Rusterholz, Robert Theiler
  • Publication number: 20240096456
    Abstract: A healthcare computer system, the computer system comprising a communications module, a string generation module, a one-way function module and an anonymised data generation module. The communications module is configured to receive one or more healthcare data packets, each healthcare data packet including: data pertaining to one or more medical analytical tests performed on a sample; a sample identifier, identifying the sample; and a timestamp, indicating when the analytical test(s) was performed. The string generation module is configured to generate a string based on the sample identifier and the timestamp. The one-way function module is configured to apply a one-way function to the generated string to generate an anonymised sample identifier. The anonymised data generation module is configured to generate an anonymised healthcare data packet including the data pertaining to the one or more medical analytical tests and the anonymised sample identifier.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 21, 2024
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Asad Preuss-Dodhy
  • Patent number: 11927597
    Abstract: A laboratory sample vessel distribution system is presented. The system comprises a cabinet, sample vessel carriers for receiving sample vessels, and a cabinet drawer for receiving a sample vessel carrier. The drawer is locatable in different positions: closed, opened, and fully opened. An actuator moves the sample vessels and the sample vessel carriers between different locations. An actuator driver drives the actuator and applies a first mode of operation with a first speed and a second mode of operation with a second reduced speed compared to the first speed. A sensor device detects between opened and closed positions and provides position signals. A control device is connected to the actuator driver and the sensor device. The control device provides control signals to the actuator driver instructing the actuator driver to apply either the first mode, if in the closed position, or the second mode, if in the opened position.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: March 12, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Andreas Schesny, Vladimirs Leontjevs
  • Publication number: 20240079101
    Abstract: A healthcare data management system for managing processing capacity in a healthcare data management system. The healthcare data management system includes: one or more processing pipelines connected to one or more of the medical devices and configured to receive medical data therefrom, wherein each processing pipeline comprises a plurality of processing stages arranged in series and configured to perform respective operations on the received healthcare data, wherein each processing stage is implemented on a stateless atomic processing unit; a healthcare middleware is configured to receive processed data therefrom and to provide the processed data to a healthcare information management system; a performance management unit is configured to monitor a performance of the or each processing pipeline and adjust a number of stateless atomic processing units implementing a given processing stage within a given processing pipeline based on the monitored performance.
    Type: Application
    Filed: August 29, 2023
    Publication date: March 7, 2024
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Javier Lira Rueda
  • Publication number: 20240071626
    Abstract: Embodiments of the present disclosure relate to automated validation of medical data. Some embodiments of the present disclosure provide a method for medical data validation. The method comprises obtaining target medical data generated in a medical test and obtaining a machine learning model for validating medical data. The machine learning model represents an association between the medical data and validation results, the validation results indicating information about predetermined actions to be performed on the medical data. The method further comprises determining a target validation result for the target medical data by applying the target medical data to the machine learning model, the target validation result indicating information about a target action selected from the predetermined actions to be performed on the target medical data. Through the solution, it is possible to achieve automated medical data validation with high accuracy and efficiency as well as reduced manual efforts.
    Type: Application
    Filed: August 26, 2022
    Publication date: February 29, 2024
    Applicants: Roche Diagnostics Operations, Inc., Qilu Hospital of Shandong University
    Inventors: Daquan Liu, Yin Qian, Xiaojun Tao, Hongchun Wang, Weibin Xing, Chenxi Zhang, Yi Zhang, Qi Zhou
  • Publication number: 20240069046
    Abstract: A monitoring device for monitoring a sample handling system comprising: a sliding unit comprising a sliding surface, wherein the sliding unit is configured for sliding over a sample transport device of the sample handling system; and an imaging streaming unit comprising s camera, wherein the camera is configured for capturing a plurality of images, wherein the imaging streaming unit comprises an imaging communication interface for providing the plurality of captured images to a transport control system of the sample handling system. Further disclosed is a transport control system for controlling transport of a plurality of sample container holders of a sample handling system, a sample handling system for handling a plurality of samples, a method for identifying an obstacle, a method for determining a distance between the obstacle and a monitoring device and a method for controlling a monitoring device and computer programs and computer-readable storage media for performing the methods.
    Type: Application
    Filed: November 6, 2023
    Publication date: February 29, 2024
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Kumar Roshan Mehta
  • Patent number: 11911768
    Abstract: A test element support comprises a heating element for heating a test element for analytical examination of a sample. The heating element comprises a substrate, which is made of at least one substrate material. The substrate comprises at least one active area configured for being heated and at least one non-active area outside the active area. The active and the non-active areas are separated by at least one thermal insulation element. The thermal insulation element has a lower thermal conductivity than the substrate material. The thermal insulation element is fully or partially embedded into the substrate. The test element support further comprises at least one heater. The heater comprises at least one heater substrate and the heater substrate is attached to the substrate, wherein the heater substrate is attached to a back face of the substrate. The back face opposes a front face of the substrate contacting the test element.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: February 27, 2024
    Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Reiner Stein, Martin Mertens, Werner Heidt
  • Patent number: 11906406
    Abstract: Provided is an automatic analysis technique that prevents liquid contained in a reaction container from locally contacting with liquid added afterward and has less occurrence frequency of equipment malfunction and high performance.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: February 20, 2024
    Assignees: Hitachi High-Tech Corporation, Roche Diagnostics Operations, Inc.
    Inventors: Daisuke Ebihara, Shinya Matsuoka, Taku Sakazume, Yuzuru Shimazaki
  • Patent number: 11908087
    Abstract: A productivity tool for an analytical laboratory is presented. The productivity tool provides aggregated operational status of all laboratory instruments within an analytical laboratory, even without access to their respective internal data stream (i.e., legacy and third party instruments) by determining operational status of a first group of instruments by capturing and processing internal data streams comprising data indicative of an operational status. The productivity tool also determines operational status of a second group of instruments by capturing and processing external surveillance stream(s) of one or more laboratory instrument(s) of the second group.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: February 20, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Bernhard von Allmen
  • Patent number: 11898997
    Abstract: A liquid chromatography (LC) system comprises an LC switching valve comprising a sample input port, aspiration pump port, needle seat port, waste port leading to a waste, LC pump port and an LC column port. A sample aspiration needle is fluidically connected to the sample input port via a sample receiving conduit, an aspiration pump is fluidically connected to the aspiration pump port. The LC system includes a needle seat fluidically connected to the needle seat port via a needle seat conduit, an LC column fluidically connected to the LC column port, and an LC pump fluidically connected to the LC pump port, for injecting the sample into the LC column when the sample aspiration needle is seated into the needle seat and when the LC pump port is fluidically connected to the needle seat port and the sample input port is fluidically connected to the LC column port.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: February 13, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Indranil Mitra
  • Patent number: D1013528
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: February 6, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Alex Weymann
  • Patent number: D1014270
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: February 13, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Alex Weymann
  • Patent number: D1014271
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: February 13, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Alex Weymann
  • Patent number: D1014272
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: February 13, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Alex Weymann
  • Patent number: D1014273
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: February 13, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Alex Weymann
  • Patent number: D1014274
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: February 13, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Alex Weymann
  • Patent number: D1015160
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: February 20, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Alex Weymann