Patents Assigned to Roche Diagnostics Operations, Inc.
  • Publication number: 20200371114
    Abstract: The present invention relates to a method for predicting the risk of a subject of rapidly progressing to chronic heart failure and/or of hospitalization due to chronic heart failure and/or death. The method is based on the determination of at least one biomarker selected from the group consisting of a BNP-type peptide, IGFBP7 (IGF binding protein 7), a cardiac Troponin, soluble ST2 (sST2), FGF-23 (Fibroblast Growth Factor 23), and Growth Differentiation Factor 15 (GDF-15), in a sample of a subject. The method may further encompass the assessment of the presence or absence of (i) abnormal midwall fractional shortening or (ii) left ventricular hypertrophy. Further envisaged by the present invention are devices adapted to carry out the present invention.
    Type: Application
    Filed: December 19, 2019
    Publication date: November 26, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Roberto Latini, Serge Masson, Dirk Block, Christian Zaugg, Thomas Dieterle, Edelgard Kaiser, Johann Karl, Vinzent Rolny, Ursula-Henrike Wienhues-Thelen
  • Publication number: 20200363440
    Abstract: A container for receiving vessels for use in an automated analyzer is presented. The container comprises a wall assembly including a first wall and a second wall. The wall assembly forms a receptacle for receiving a vessel having one or more covers or lids. At least one of the first and second walls moves to provide a first open configuration for receiving the vessel and a second closed configuration. The container further comprises an actuator configured to translate the vessel from a first position after being received in the container to a second position and the wall assembly in the second closed configuration is positioned so that at least one engaging element attached to the wall assembly engages with the covers or lids of the vessel to open the covers or lids while the vessel is being translated by the actuator from the first position to the second position.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 19, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Stephan Sattler
  • Publication number: 20200348294
    Abstract: The present disclosure relates to hypercrosslinked magnetic particle with a polymer matrix and at least one magnetic core (M), wherein the polymer matrix has at least one crosslinked polymer having at least one hypercrosslinking bond, wherein the hypercrosslinking bond is a molecule having at least two nitrogen atoms within its structure which are part of the hypercrosslinking bond; and having at least one positive charge. Further, the disclosure relates to a method of preparing the hypercrosslinked magnetic particle and also to hypercrosslinked magnetic particle obtained or obtainable from the method. Also described is the use of the hypercrosslinked magnetic particles for enrichment or purification of at least one analyte as well as to the use of the hypercrosslinked magnetic particles for purification of water.
    Type: Application
    Filed: July 17, 2020
    Publication date: November 5, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Gaston Hubertus Maria Vondenhoff, Stephan Hug
  • Patent number: 10815517
    Abstract: Described is a method aiding in the assessment of the presence of cancer. The method uses the soluble DPPIV/seprase protein complex (DPPIV/seprase) as a universal marker of different cancer types. Measurement of DPPIV/seprase complex can, e.g., be used in the early detection or diagnosis of cancer or in the surveillance of patients who undergo surgery.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: October 27, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Magdalena Swiatek-de Lange, Johann Karl, Wolfgang Rollinger
  • Publication number: 20200333360
    Abstract: The present invention relates to a method for diagnosing a transitory ischemic attack (TIA) in a subject who is suspected to have exhibited a transitory ischemic attack, but who did not exhibit a stroke. The method is based on the determination of the amount of NT-proANP in a sample from said subject. Moreover, the present invention is directed to a method for diagnosing an acute cerebral ischemic event in a subject based on the determination of the amounts of NT-proBNP and NT-proANP in a sample from a subject. The method further comprises the step of calculating a ratio of the amounts of NT-proBNP and NT-proANP. Further envisaged by the present invention are kits and devices adapted to carry out the method of the present invention.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 22, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Georg Hess, Andrea Horsch, Dietmar Zdunek
  • Patent number: 10809273
    Abstract: A method of determining an analyte concentration in a sample by a sensor is disclosed. The method includes analyzing a sample signal generated by the sensor for an analyte being measured. If the sample signal is normal, the method includes comparing the sample signal with a first reference signal of a reference solution measured prior to measuring the sample in order to determine the analyte concentration. If the sample signal is abnormal, the method includes comparing the sample signal with a calculated reference signal point obtained by interpolation between the first reference signal and a second reference signal of the same reference solution measured after measuring the sample. Various methods of determining and handling errors based on signal patterns are also disclosed.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: October 20, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Li Gan
  • Patent number: 10809245
    Abstract: A test element analysis system for the analytical examination of a sample comprising: at least one evaluation device with at least one test element holder and at least one measuring device for measuring a change in a measuring zone of a test element; at least one barcode reader comprising at least one circuit board having a front side facing the barcode of the test element positioned in the test element holder and a reverse side facing away from the test element, wherein at least one electronic control element of the barcode reader is disposed on the circuit board and wherein the circuit board comprises at least one cavity penetrating the circuit board; at least one camera carrier element; and at least one camera electrically connected to the camera carrier element, with the camera carrier element and the camera being positioned such that the camera observes the barcode through the cavity.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: October 20, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Kai Hebestreit, Sylvia Saecker, Klaus Thome, Marina Swan Backhaus
  • Patent number: 10809258
    Abstract: A method for determination of the amount of a specific analyte in a sample which may show a prozone effect by photometric assays, wherein the specific analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific assay reagents. The optical signal is measured simultaneously for the specific analyte in the sample to be determined at the wavelength used for the determination of the analyte and at least at an additional specific wavelength used for the detection of the prozone effect over the complete reaction time. The reaction rate ratio R is calculated by using the signals obtained at the wavelength used for the detection of the prozone effect. By comparison of the calculated ratio value R with predetermined limit values it is judged if a prozone effect is present in the sample.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: October 20, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ewelina Hegel, Georg Kurz, Eloisa Lopez-Calle, Josef Roedl
  • Publication number: 20200315508
    Abstract: A medical instrument and method thereof for performing a measurement on a biological sample using a test strip are disclosed. The medical instrument may comprise: an analytical unit for analyzing the test strip, wherein the analytical unit comprises a test strip mount which receives the test strip to perform the measurement; a test strip port which receives the test strip, wherein the test strip port is aligned with the test strip mount along an insertion direction; and a shutter movable between open and closed positions, the shutter comprises a test strip opening, wherein the test strip opening is aligned with the test strip port and the test strip mount when the shutter is in the open position, wherein the shutter comprises a shutter mechanism that rotates the shutter parallel to the insertion direction about a rotational axis to move the shutter between the open position and the closed position.
    Type: Application
    Filed: June 23, 2020
    Publication date: October 8, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Klaus Thome, Reiner Stein, Lars Fischheiter, Jerome Greenhalgh
  • Publication number: 20200312448
    Abstract: A productivity tool for an analytical laboratory is presented. The productivity tool provides aggregated operational status of all laboratory instruments within an analytical laboratory, even without access to their respective internal data stream (i.e., legacy and third party instruments) by determining operational status of a first group of instruments by capturing and processing internal data streams comprising data indicative of an operational status. The productivity tool also determines operational status of a second group of instruments by capturing and processing external surveillance stream(s) of one or more laboratory instrument(s) of the second group.
    Type: Application
    Filed: March 27, 2020
    Publication date: October 1, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Bernhard von Allmen
  • Publication number: 20200310395
    Abstract: A computer implemented method of operating a diagnostic instrument such that maintenance processes do not conflict with operator activity is presented. A maintenance process conflicts with operator activity if the probability of use of the diagnostic instrument is above a usage probability threshold. The probability of use of the diagnostic instrument is determined based on detected presence and/or movement of an operator in the proximity of the diagnostic instrument and/or operation of the diagnostic instrument.
    Type: Application
    Filed: March 3, 2020
    Publication date: October 1, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Christopher Bradbury, Scott Perala
  • Publication number: 20200300869
    Abstract: The present disclosure demonstrates a method for predicting the risk of stroke of a subject and a method for improving the prediction accuracy of a clinical stroke risk score. The methods are based on the determination of the amount of Angiopoietin-2 (Ang-2) and/or the amount of Insulin-like growth factor-binding protein 7 (IGFBP7) in a sample from a subject. Moreover, disclose is the use of i) the biomarker Ang-2 and/or the biomarker IGFBP7, and/or ii) at least one detection agent that specifically binds to Ang-2 and/or at least one detection agent that specifically binds to IGFBP7 in a sample from a subject for predicting the risk of stroke of said subject.
    Type: Application
    Filed: June 12, 2020
    Publication date: September 24, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Ursula-Henrike Wienhues-Thelen, Johann Karl, Peter Kastner, Vinzent Rolny, Andre Ziegler, David Conen
  • Patent number: 10782232
    Abstract: A Quality Control (QC) material for performing a QC procedure with respect to at least one detector is introduced. The QC material comprises at least one first QC substance and at least one second QC substance, wherein the first QC substance is interferable with the second QC substance or with the performance and/or lifetime of the detector and wherein the first QC substance is entrapped by carrier particles that prevent the first QC substance to interfere with the second QC substance or with the performance and/or lifetime of the detector. An in-vitro diagnostic system comprising a first detector and a second detector and the QC material is also introduced. An in-vitro diagnostic method comprising performing a QC procedure with respect to a first detector and/or to a second detector comprising providing the QC material is also introduced, as well as a method of manufacturing the QC material.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: September 22, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Sabrina Stevanovic, Rebecca Ravotti
  • Publication number: 20200292483
    Abstract: A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.
    Type: Application
    Filed: June 14, 2019
    Publication date: September 17, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Michael Marquant, Samuel Evgin, Melanie Klein
  • Patent number: 10775396
    Abstract: A sample handling device is presented. The sample handling device comprises at least one magnetic positioning device for magnetically holding a carrier configured for carrying at least one vessel in the sample handling device. A sample identification device is also presented. The sample identification device comprises at least one of the above sample handling device and at least one reader for reading at least one identifier attached to the vessel carried by the carrier. A system for sample handling, a diagnostics device for identifying at least one property of a plurality of samples and a method for handling a sample are also presented.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: September 15, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Sabrina Gemperle, Eugen Lusser, David Huber, Michal Malinowski
  • Patent number: 10775355
    Abstract: A clinical diagnostic system is presented and comprises a sample preparation station for automatically preparing samples comprising analytes of interest, a liquid chromatography (LC) separation station comprising a plurality of LC channels and a sample preparation/LC interface for inputting prepared samples into the LC channels. The system further comprises a controller to assign samples to pre-defined sample preparation workflows each comprising a pre-defined sequence of sample preparation steps and requiring a pre-defined time for completion depending on the analytes. The controller further assigns an LC channel for each prepared sample depending on the analytes and plans an LC channel input sequence for inputting the prepared samples that allows analytes from different LC channels to elute in a non-overlapping LC eluate output sequence based on expected elution times.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: September 15, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Tobias Franz, Uwe Kobold, Peter Kupser, Roland Thiele
  • Patent number: 10766652
    Abstract: A carrier element for use in a packaging device is provided wherein the carrier element is connectable with at least one transport device of the packaging device. The carrier element comprises at least one receiving surface for receiving at least one package. The receiving surface comprises at least one suction opening for fixing the package by suction. The carrier element further comprises at least one pressure reservoir connected to the suction opening. The carrier element further comprises at least one pressure sensor for measuring a pressure inside the pressure reservoir. A packaging device for packaging at least one product into at least one package is also disclosed. The packaging device comprises at least one carrier element and at least one transport device, wherein the carrier element is connected to the transport device.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: September 8, 2020
    Assignees: Roche Diagnostics GMBH, Roche Diagnostics Operations, Inc.
    Inventors: Thomas Jasiulek, Andreas Trapp
  • Publication number: 20200271670
    Abstract: The present description relates to a method for identifying a patient who is eligible for an intensification of heart failure therapy. Furthermore, the description relates to a method for pikej3optimizing B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy. The methods are based on the measurement of the level of at least one marker in a sample from a patient who has heart failure and who receives B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy. Further described are kits and devices adapted to carry out the described method.
    Type: Application
    Filed: May 7, 2020
    Publication date: August 27, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Dirk Block, Hans-Peter Brunner, Ursula-Henrike Wienhues-Thelen, Christian Zaugg, Thomas Dieterle, Cheryl Mitchell, Johan Ubby, Sandra Sanders-van Wijk
  • Patent number: 10752436
    Abstract: A secondary solid waste container for solid waste of an analyzer is disclosed. The secondary solid waste container comprises side walls and an impact absorbing member. The side walls comprise an upper end and a lower end. The impact absorbing member is connected to the side walls such that the impact absorbing member extends between the side walls and is spaced apart from the lower end with respect to a direction from the lower end to the upper end. The impact absorbing member is configured to absorb an impact from solid waste of the analyzer. An analyzer and a method for removing solid waste of an analyzer are also disclosed.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: August 25, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: David Huber, Bruno Koch, Franz Lindegger, Marco Sangermano
  • Patent number: D900147
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: October 27, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Luc St. Arnaud, Sandra Roth, Olgu Guenal