Patents Assigned to Roche Diagnostics Operations, Inc.
  • Publication number: 20190276872
    Abstract: A method for determining a non-anticoagulant interferent in a blood-derived sample of a subject, the method comprising a) determining a value of a coagulation time-related parameter in the sample; b) comparing the value of the coagulation time-related parameter determined in a) to a value of the coagulation time-related parameter determined in at least one reference sample; and c) based on the result of comparison step b), determining the non-anticoagulant interferent in a blood-derived sample of a subject. A method for identifying a blood-derived sample having insufficient quality is further disclosed, the method comprising determining non-anticoagulant interferent(s) according to the aforesaid method, and to devices, kits, and uses related thereto.
    Type: Application
    Filed: May 29, 2019
    Publication date: September 12, 2019
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Andrea Lichte, Michael-Harold Town
  • Publication number: 20190279770
    Abstract: The present disclosure relates to a method of identifying a subject who is at risk of progressing to left ventricular hypertrophy (LVH), using the steps of measuring the amount of the biomarker soluble ST2 and comparing the thus measured amount to a reference. Further encompassed by the present disclosure are kits and devices adapted to carry out the method of the present invention.
    Type: Application
    Filed: October 12, 2018
    Publication date: September 12, 2019
    Applicants: Roche Diagnostics Operations, Inc., Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu
    Inventors: Dirk Block, Ursula-Henrike Wienhues-Thelen, Christian Zaugg, Andre Ziegler, Faiez Zannad, Patrick Rossignol
  • Publication number: 20190277861
    Abstract: The present disclosure relates to a method for diagnosing and/or grading diastolic dysfunction or at least one structural or functional abnormality associated with diastolic dysfunction. The method involves measuring the level of IGFBP7 (Insulin like growth factor binding protein 7) and, optionally, the level of at least one further marker in a patient suffering from heart failure, and comparing the level to a reference level. Further envisaged is a method of monitoring diastolic function in a patient suffering from heart failure. Also encompassed by the present disclosure are kits and devices adapted to carry out the method of the present invention.
    Type: Application
    Filed: May 23, 2019
    Publication date: September 12, 2019
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Johann Karl, Ursula-Henrike Wienhues-Thelen, Dirk Block, Christian Zaugg, Hans-Peter Brunner, James Januzzi, Andre Ziegler, Julian Braz, Thomas Dieterle, Edelgard Kaiser
  • Publication number: 20190279755
    Abstract: A device and method of providing instruction to a patient regarding the dosing of insulin is provided.
    Type: Application
    Filed: May 20, 2019
    Publication date: September 12, 2019
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Maury Zivitz, Lois Jovanovic
  • Publication number: 20190271713
    Abstract: A method for predicting a failure state of an automated analyzer for analyzing a biological sample is disclosed. The method includes obtaining a prediction algorithm for predicting a failure state of an automated analyzer. The prediction algorithm is configured to predict a failure state of the automated analyzer based on calibration data and/or quality control data generated by an automated analyzer. The method also includes obtaining calibration data and/or quality control data of the automated analyzer and processing the calibration data and/or quality control data by using the prediction algorithm to predict a failure state of the automated analyzer.
    Type: Application
    Filed: May 20, 2019
    Publication date: September 5, 2019
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Fabian Heinemann, Stefan Kobel, Sven Dahlmanns, Jean-Philippe Vert, Yunlong Jiao
  • Publication number: 20190250158
    Abstract: The present disclosure relates to a method for detecting an analyte involving a) contacting the analyte, a capture agent and a solid surface to form a capture complex attached to a solid surface, b) cleaving at least one covalent bond within the analyte and/or within said capture agent in the capture complex and, thereby, releasing the analyte or a fragment thereof from the capture complex, and c) detecting at least one fragment of the analyte and, thereby, detecting the analyte. The present disclosure further relates to a kit having i) a capture agent binding to an analyte; and ii) an agent cleaving at least one covalent bond within the analyte and/or within the capture agent; and to the use of a protease for releasing fragments of an analyte for detecting the analyte, wherein the analyte is bound to a solid surface via a capture agent.
    Type: Application
    Filed: April 19, 2019
    Publication date: August 15, 2019
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Uwe Kobold, Robert Lang, Andreas Leinenbach
  • Patent number: 10379014
    Abstract: A method for preparing a biological sample for analysis is provided that includes moving a continuous substrate film past a sample applicator unit including one or more sample applicators and applying at least one trace of a biological sample to be analyzed onto the continuous substrate film by the sample applicator unit.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: August 13, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Andreas Calatzis, Harald Leyser
  • Patent number: 10369281
    Abstract: Devices, systems and methods for adjusting fluid delivery based on past or historical fluid delivery data and/or personal parameters of a user are disclosed. Devices, and corresponding systems and methods, may comprise a dispensing unit configured to deliver a fluid from a reservoir into the body of a user and a processor having instructions operating thereon to retrieve data relating to one or more time windows from a memory, assess a correction delivery for the one or more time windows based on the data, determine a new CIR value for the one or more time windows if the correction delivery regularly follows a meal bolus and/or determine a new basal delivery profile for the one or more time windows if the correction delivery regularly precedes a meal bolus.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: August 6, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ofer Yodfat, Gali Shapira, Iddo Gescheit
  • Publication number: 20190232292
    Abstract: A test element support comprises a heating element for heating a test element for analytical examination of a sample. The heating element comprises a substrate, which is made of at least one substrate material. The substrate comprises at least one active area configured for being heated and at least one non-active area outside the active area. The active and the non-active areas are separated by at least one thermal insulation element. The thermal insulation element has a lower thermal conductivity than the substrate material. The thermal insulation element is fully or partially embedded into the substrate. The test element support further comprises at least one heater. The heater comprises at least one heater substrate and the heater substrate is attached to the substrate, wherein the heater substrate is attached to a back face of the substrate. The back face opposes a front face of the substrate contacting the test element.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 1, 2019
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Reiner Stein, Martin Mertens, Werner Heidt
  • Patent number: 10359442
    Abstract: A sample container carrier for transporting sample containers, for example test tubes and/or vials, in a laboratory automation system is presented. The sample container carrier comprises a body having a hollow center with a central axis. The hollow center accommodates a lower end of a sample container. The sample container carrier also comprises three resiliently deformable and/or displaceable first retaining elements mounted to the body. The first retaining elements, distributed about the central axis, clamp a sample container inserted in the hollow center. The sample container carrier also comprises three resiliently deformable and/or displaceable second retaining elements mounted to the body. The second retaining elements, distributed about the central axis, clamp the sample container inserted in the hollow center underneath the three first retaining elements. The second retaining elements are arranged at least partly inside the hollow center.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: July 23, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Marcel Kaeppeli, Pius Hermann
  • Patent number: 10350354
    Abstract: A device and a method for prevention of hypoglycemia are disclosed. In one aspect, the device and the method for prevention of hypoglycemia can comprise receiving a target blood glucose (TBG) level corresponding to a desired level of glucose in a patient's body during a fasting time period; receiving a bedtime blood glucose (BBG) level corresponding to a level of glucose in the patient's body substantially at a beginning of the fasting time period (e.g. before bedtime); receiving a first set of parameters corresponding to a medical state of the patient; determining a therapeutic course of action based on the levels of the TBG, BBG and the medical state of the patent; and administering the therapeutic course of action to the patient.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: July 16, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ofer Yodfat, Gali Shapira, Neesha Ramchandani
  • Patent number: 10352953
    Abstract: A method of operating a laboratory sample distribution system is disclosed. The laboratory sample distribution system comprises a plurality of sample container carriers. The sample container carriers carry one or more sample containers. The sample containers comprise samples to be analyzed by a plurality of laboratory stations. The system also comprises a transport plane. The transport plane supports the sample container carriers. The transport plane comprises a plurality of transfer locations. The transfer locations are assigned to corresponding laboratory stations. The system also comprises a drive. The drive moves the sample container carriers on the transport plane. The method comprises, during an initialization of the laboratory sample distribution system, pre-calculating routes depending on the transfer locations and, after the initialization of the laboratory sample distribution system, controlling the drive such that the sample container carriers move along the pre-calculated routes.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: July 16, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Tobias Huber, Achim Sinz, Namitha Mallikarjunaiah, Oliver Denninger, Mohammadreza Mahmudimanesh, Timo Fleischmann, Domenic Jenz
  • Patent number: 10345322
    Abstract: A cartridge for dispensing a fluid is provided, the cartridge comprising: a reservoir chamber configured for receiving the fluid, the reservoir chamber having a fluid outlet and a cover with a first bearing; and a stirring assembly comprising a stirrer located inside the reservoir chamber, the stirring assembly comprising a shaft connected to the stirrer. The stirring assembly can be moved between first and second positions, wherein in the first position the stirring assembly can seal the fluid outlet, the stirring assembly in the first position being configured to form a second bearing with the reservoir chamber or the fluid outlet such that the stirrer can be rotated about an axis defined by the first and second bearing, and wherein if the stirring assembly is in the second position the fluid can pass through the fluid outlet, the shaft being configured to transmit rotational power to the stirrer.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: July 9, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Thorsten Brueckner, Christoph Boehm, Juergen Spinke
  • Patent number: 10346733
    Abstract: A reagent container carrier structure for holding at least one reagent container, wherein the carrier structure has thereon an RFID assembly and an optically detectable definition pattern defining an orientation of the carrier structure, is disclosed. The reagent container carrier structure may have an orientation identification label that has a front surface and a back surface, and further include an RFID assembly positioned on the back surface, and an optically detectable definition pattern defining an orientation of the label on the front surface. A reader module for reading RFID data in combination with optically detectable data defining an orientation of a respective label is also disclosed.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: July 9, 2019
    Assignees: ROCHE DIAGNOSTICS OPERATIONS, INC., HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Stephan Sattler, Yusuke Minemura, Takuya Yamaguchi
  • Patent number: 10345315
    Abstract: Disclosed herein is a method for diagnosing and/or grading diastolic dysfunction or at least one structural or functional abnormality associated with diastolic dysfunction. The method involves measuring the level of IGFBP7 (Insulin like growth factor binding protein 7) and, optionally, the level of at least one further marker in a patient suffering from heart failure, and comparing the level to a reference level. Also disclosed is a method of monitoring diastolic function in a patient suffering from heart failure, and kits and devices for performing the method.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 9, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Johann Karl, Ursula-Henrike Wienhues-Thelen, Dirk Block, Christian Zaugg, Hans-Peter Brunner, James Januzzi, Andre Ziegler, Julian Braz, Thomas Dieterle, Edelgard Kaiser
  • Patent number: 10337048
    Abstract: The present invention concerns diagnostic methods for coagulation testing involving determining anticoagulant activity elicited by a first anticoagulant in a sample comprising measuring a first Factor Xa activity in a body fluid test sample of said subject, measuring a second Factor Xa activity in at least one calibrator sample comprising a predefined anticoagulation activity for a second anticoagulant, calculating an universal parameter for the anticoagulation activity comprised in the test sample based on the first and the second measured Factor Xa activities and comparing the said parameter for the anticoagulation activity with predefined ranges of expected anticoagulation activity for at least three anticoagulants. Further provided is a computer program code assisting the method as well as a system for carrying out the said method as well as a kit.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: July 2, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Friedrich Ackermann, Andreas Calatzis
  • Patent number: 10336547
    Abstract: A sample container handling device is presented. The device comprises a linear transport unit and a release unit comprising a release blade segment. The release blade segment is rotated in a constant rotational direction.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: July 2, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Reto Andrin Meier, Alina Iwan
  • Patent number: 10338086
    Abstract: A method for supplying consumable items to an automated sample analyzer is presented. The automated analyzer comprises a consumable repository including two or more storage areas. Each area is configured to store a plurality of consumable items. The method comprises receiving one or more orders for analytical tests to be carried out by the analyzer, reserving consumable items corresponding to one or more sets of consumable items required for the analytical tests in a first area, switching to a second area for reserving consumable items in response to determining that a predetermined consumable item in the first area has been reserved, supplying the reserved consumable items for use in the one or more analytical tests and indicating that the first area can be replenished in response to determining that a particular consumable item of the first storage area has been used.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: July 2, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Marco Maetzler, Liutger Joannes Franzen, Florian Zwahlen, Hans Reischauer, Adrian Cojocaru, Stephan Topsakalian
  • Patent number: D853581
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: July 9, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Armin Bucher, Thomas Guggisberg, Stephan Sattler, Martin Halter
  • Patent number: D858775
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: September 3, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Craig Ian Wightman, Johann Florian Wassermann, Michael John Unwin