Abstract: The present invention relates to a method and the use thereof for determining the level of Vitamin D and metabolites thereof. Further, it is an object of the present invention to provide a kit and the use thereof for determining the level of Vitamin D and metabolites thereof.

Abstract: A method for determining system resistance of at least one power supply of a handheld medical device, the method including: a) generating at least one excitation voltage signal, wherein the excitation voltage signal comprises at least one direct current (DC) voltage signal, wherein the excitation voltage signal has a fast transition DC flank of 20 ns or less; b) applying the excitation voltage signal to at least one reference resistor having a predetermined or pre-defined resistance value, wherein the reference resistor is arranged in series with the power supply; c) measuring a response signal of the power supply; d) determining a signal flank from the response signal and determining an ohmic signal portion from one or both of shape and height of the signal flank; and e) determining the system resistance of the power supply from the ohmic signal portion.

Abstract: The present invention relates to monoclonal antibodies binding to the nucleocapsid protein of SARS-CoV-2 virus, nucleic acids encoding said antibody, host cells producing the same, compositions and kits comprising said antibodies, as well as methods of detecting SARS-CoV-2 virus in a sample comprising using said antibodies.

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

Abstract: The present invention relates to bacterial pilus protein complex FimGt-DsF stabilized protein complexes for producing phagemids or filamentous phages, and methods for use of these.

Abstract: The present disclosure relates to a solid phase coated with (strept)avidin and having attached thereto, by way of biotin:(strept)avidin interaction, a biotinylated first member of a binding pair, wherein the attached first member is capable of binding to a second member of the binding pair, but is not capable of binding to biotin or to (strept)avidin, and wherein no member of the binding pair is capable of hybridizing with a naturally-occurring single-stranded nucleic acid. The solid phase is particularly useful in immunoassays with samples having high content in biotin or (strept)avidin-binding derivatives thereof. The present disclosure further provides uses, kits and methods, particularly for determination of an analyte in a sample.

Abstract: A computer-implemented method of consolidating critical information for a patient in a laboratory is presented. The method comprises selecting a patient to monitor from a population of patients associated with the laboratory, extracting information for the patient from a plurality of laboratory sources in the laboratory, determining if the extracted patient information is critical to care of the patient, and outputting the extracted patient critical information to a single display dashboard for display to a laboratory operator.

Abstract: The present invention relates to an instrument for automatically removing sealing covers from sample vessels (and/or for automatically sealing or resealing sample vessels with sealing covers, the instrument comprising a vessel holder for holding a sample vessel, and a suction/induction device comprising a suction member for holding a sealing cover, and an induction member comprising at least one induction coil, with the suction/induction device and the vessel holder being arranged in an axially movable manner with regard to each other, and, in use, the at least one induction coil is arranged above a bottom of the suction member. In addition, the present invention relates to a laboratory automation system comprising such instrument as well as a plurality of pre-analytical, analytical and/or post-analytical stations, and also relates to a method of automatically removing sealing covers from sample vessels and a method of automatically sealing or resealing sample vessels with sealing covers.

Abstract: The invention relates to a complex comprising an antibiotic substance and a nucleophilic derivatization reagent, compositions comprising the complex, kits comprising complex or composition, as well as uses of the complex or composition.

Abstract: A computer-implemented method generates a message filter configuration based on a message priority indication of analytical device status messages received from a first analyzer network, the configuration based on identifying a type of analytical device status data associated with the message priority indication. The method includes communicating the message filter configuration, or a portion thereof, to a second analyzer network comprising a second analytical device.

Abstract: A method for operating a laboratory system comprising laboratory instruments and a laboratory information system is presented. The method comprises grouping laboratory instruments into instrument cluster(s) and providing a cluster manager thereto. The plurality of laboratory instruments publishes their instrument resource descriptions. Each cluster manager maintains an inventory of cluster resources and publishes a list of processing capabilities of the instrument cluster. The laboratory information system assigns processing of test order(s) to instrument clusters. Each cluster manager assigns resources of the laboratory instruments corresponding to test orders from the laboratory information system in view of the inventory of cluster resources. Each laboratory instrument carries out the processing step(s) on the biological sample as instructed by the cluster manager.

Abstract: The present invention refers to a method for determining peptide fragments of glycated hemoglobin A (HbA1c) molecules by mass spectrometry (MS), a reagent kit, and a clinical diagnostic system adapted for performing the method.

Abstract: A system for supplementing measurement results of automated analyzers is presented. The system includes a computer device configured for obtaining a result of a measurement performed by an automated analyzer, the computer device and the automated analyzer being located within a privileged computer network, obtaining a context related algorithm associated with the result of the measurement defining one or more triggering conditions and context related information from a computer device residing outside of the privileged computer network at the computer device and processing the result of the measurement by using the context related algorithm to generate a context specific supplement to the result of the measurement at the computer device.

Abstract: A target (110) for use in a laser desorption mass spectrometer is disclosed. The target (110) has at least one surface (112). wherein the surface (112) is covered at least partially with at least one layer (114), wherein the layer (114) is a hydrogen comprising, silicon-incorporated amorphous carbon (a-C:H:Si) layer (116), wherein the a-C:H:Si layer (116) comprises: 40 at. % to 80 at. % of carbon; 1 at. % to 20 at. % of hydrogen; and 10 at. % to 40 at. % of silicon.

Abstract: A method of handling laboratory sample containers is disclosed. The method comprises moving a laboratory sample container to a target position. The target position is a position at which the laboratory sample container is inserted into a corresponding orifice of a laboratory sample container rack provided that the laboratory sample container rack is placed at an intended position. The laboratory sample container is prevented from moving vertically due to gravity if correctly inserted into the corresponding orifice of the laboratory sample container rack. The method also comprises releasing the laboratory sample container in a vertical direction such that the laboratory sample container can move in the vertical direction due to gravity, determining if the laboratory sample container moves in the vertical direction, and performing an error procedure if it is determined that the laboratory sample container moves in the vertical direction.

Abstract: A computer implemented method for automatic peak integration of at least one chromatogram of at least one sample. The method comprises retrieving at least one chromatogram of the chemical related substance and at least one chromatogram of the analyte; evaluating the chromatogram of the chemical related substance, wherein the evaluating comprises determining at least one initial value for analyte retention time by determining retention time of the chemical related substance and adding the retention time of the chemical related substance with a pre-determined or pre-defined constant offset and/or multiplying the retention time of the chemical related substance with a pre-determined or pre-defined constant factor; evaluating the chromatogram of the analyte, wherein the evaluating comprises at least one position determining step; and at least one peak integration step, wherein analyte peak area and analyte peak shape are determined by applying at least one fitting analysis to the chromatogram of the analyte.

Abstract: The present invention relates to a monoclonal antibody, or fragment thereof, which binds to CSF-1R (Colony stimulating factor 1 receptor), in particular to human CSF-1R. The present invention further relates to the in vitro use of the monoclonal antibody, or fragment thereof, of the present invention for the detection of CSF-1R in a sample. Further encompassed by the present invention is a complex comprising the monoclonal antibody, or fragment thereof, of the present invention and CSF-1R such as the human CSF-1R polypeptide.

Abstract: A distribution system is disclosed. The distribution system comprises a transport plane comprising logical positions, carriers for transporting objects, a drive system to move the carriers on the transport plane between logical positions, a control system configured for controlling the carriers to move on a planned route from a start position to a final destination position on the transport plane via logical positions, wherein the control system comprises a routing system configured for calculating routes for at least two carriers on the transport plane by modeling the transport plane with graphs of nodes, wherein the routing system is configured for calculating the planned routes considering balancing of surface usage of the transport plane, and wherein the routing system is configured for considering temporal blocking of logical positions and/or a considering variable move length and/or considering a variable reservation length.

Abstract: A laboratory analyzer is disclosed. The laboratory analyzer comprises a housing at least partially enclosing at least one analyzing instrument and at least one display device, wherein the display device comprises at least one screen, wherein the screen is partially transparent and reflective, wherein the screen is integrated into the housing, wherein the display device is configured for displaying screen information on the screen such that the screen information is visible and/or readable from outside the housing.

Abstract: A sample carrier transport device for transporting sample carriers to a workstation. The sample carrier transport device comprises a surface having a plurality of sample carrier holder portions. Each sample carrier holder portion is configured for removably holding a sample carrier during transport of the sample carrier. The surface performs a movement for transporting the sample carrier to the workstation. The sample carrier transport device comprises a lifting mechanism for moving the surface to at least one transport position and to at least one transfer position. The transport position and the transfer position refer to different heights of the surface. The lifting mechanism is configured for holding the surface during transport of the sample carriers to the workstation in the transport position. The sample carrier transport device is configured for handing over the sample carrier to the workstation and for receiving the sample carrier from the workstation in the transfer position.