Abstract: Herein is reported a cultivation system for cultivating a pool of ovine B-cells or single deposited ovine B-cells in the presence of phorbol myristate acetate (PMA).

Abstract: A gripping device for handling sample containers is presented. The sample containers are closed by caps of a given cap type or are not closed by caps. The gripping device comprises a number of fingers configured to collectively cause gripping of a sample container, a tactile sensor device arranged at at least one of the fingers and configured to sample a longitudinal profile of the sample container and of the cap, if any, being gripped, and a control device coupled to the tactile sensor device. The control device determines if the sample container is closed by a cap or not closed by a cap based on the sampled longitudinal profile.

Abstract: A method for operating a transport device in a laboratory sample distribution system, comprising: providing a transport device in a laboratory sample distribution system, the transport device having an arrangement of transport modules, wherein each transport module is provided with a transport surface; a drive device configured to move sample vessel carriers on the transport surface; a module control device configured to control operation of the drive device; and a module network interface connected to the module control device and configured for data communication in a control network; a transport plane; and a controller device connected to the control network through a controller network interface; and assigning a network address to each of the transport modules in the control network; for each transport module, in the module control device storing its own network address and the network address of neighboring transport modules located adjacent to the transport module.

Abstract: A computer implemented method for identifying at least one peak in a mass spectrometry response curve is provided comprising: a) providing at least one mass spectrometry response curve by using at least one mass spectrometry device; b) evaluating the mass spectrometry response curve by using at least one trained model thereby identifying a start point and an end point of at least one peak of the mass spectrometry response curve, wherein the model was trained using a deep learning regression architecture.

Abstract: An automatic analyzer for analyzing samples comprising an immersion tube configured to retrieve a reagent stored in a reagent vessel and a lifting device configured to lift and lower the immersion tube. The lifting device comprises a guide rail on which the immersion tube is moveable between a lowered position, in which the immersion tube is immersed into the reagent vessel, and a lifted position, in which the immersion tube is retracted from the reagent vessel, and at least one biasing member configured to bias the immersion tube towards the lowered position with a predetermined biasing force. The analyzer further comprises a detector configured to detect an identity of the reagent, and a locking device configured to lock the immersion tube in the lifted position and so the immersion tube is moved towards the lowered position only if the reagent identity detected by the detector corresponds to a target identity.

Abstract: The present disclosure relates to a method for determining a carry over of an analyte from a previous sample into a sample of interest on a liquid chromatography mass spectrometer (LC-MS) device, the method comprising the following steps: (a) determining at least one chromatogram of said sample of interest on said LC-MS device; (b) determining a background height of the chromatogram; and (c) determining the carry over of the analyte from said previous sample into the sample of interest based on the background height. The present disclosure also relates to methods, systems, and computer program products related to the aforesaid method.

Abstract: A method for identifying and/or verifying at least one analyte peak in a chromatogram of a sample for said analyte from a liquid chromatography mass spectrometer device, said method comprising: a) determining a chromatogram of the sample by acquiring a plurality of data points for quantifier signal intensities and/or qualifier signal intensities, over time; and, in case the sample comprises an internal standard, optionally acquiring a plurality of data points for internal standard quantifier signal intensities and/or internal standard qualifier signal intensities, over time; b) determining for at least a fraction of the data points acquired in step a), a ratio type; c) comparing the ratios determined in step b) to a reference; and d) identifying and/or verifying at least one analyte peak in a chromatogram based on comparison step c).

Abstract: The present disclosure provides the sequence of a Paenibacillus polymyxa preproenzyme which is the precursor of a neutral protease, expression thereof in a transformed host organism, and methods for production of the neutral protease, by recombinant means. Further, use of the recombinantly produced neutral protease is disclosed in the field of cell biology, particularly for the purpose of tissue dissociation. The disclosure also includes blends with other proteases. Further disclosed are nucleotide sequences encoding the neutral protease.

Abstract: A system for providing clinical decision support to a user is presented. The system comprises a Point-of-Care (POC) testing device comprising an integrated clinical decision support module. The POC testing device and the clinical decision support module are connected via a testing module-clinical decision support module interface. The system comprises a testing module between the user and the POC testing device. The testing module requests tests from the user to the POC testing device and sends completed test results from the POC testing device to the user and to the clinical decision support module via the internal interface. The system comprises outside data sources to provide external data via a communication connection to the clinical decision support module of the POC testing device. The clinical decision support module uses the external data and the completed test results to determine and provide clinical decision support information specifically tailored to the user.

Abstract: An analyte detector for detecting at least one analyte in at least one fluid sample is proposed. The analyte detector comprises at least one multipurpose electrode exposable to the fluid sample. The analyte detector further comprises at least one field-effect transistor in electrical contact with the at least one multipurpose electrode. The analyte detector further comprises at least one electrochemical measurement device configured for performing at least one electrochemical measurement using the multipurpose electrode.

Abstract: An automated method for detecting and/or monitoring a state of a degasser of an analyzer is provided, the degasser including a container configured to be evacuated. The method includes obtaining a time series of values indicative of pressures inside the container. The time series spans a period during which the container is evacuated or pressurized. The method further includes determining a liquid level state of the degasser which is determined by an amount of liquid present in the container based on the time series.

Abstract: In an automatic analyzer in which required maintenance can be executed efficiently, without omission, an operation control unit controls operations of an analysis module (ISE, AU1, AU2) including a sample vessel transport mechanism, a reagent vessel transport mechanism, a reaction vessel transport mechanism, a sample dispensing mechanism, and a reagent dispensing mechanism, and of a display unit, and analyzes a sample accommodated in a reaction vessel. The operation control unit stores a validity period for each maintenance item of the analysis module (ISE, AU1, AU2) and an execution time for each maintenance item in a memory, displays an execution time together with an identification representation of execution priority level based on the expiration dates on the display unit, rearranges the display order of the maintenance items on the basis of the execution priority level, in accordance with an operator's instruction inputted through an operation input portion.

Abstract: A method is presented.

Abstract: A method of automatically customizing user training on a laboratory system is presented. The method comprises retrieving a configuration file of the laboratory system, logging into the laboratory system by a laboratory user, identifying and authenticating the laboratory user for use and training on the laboratory system, after the laboratory user is identified and authenticated by the laboratory system, retrieving training credentials required for that laboratory user for the laboratory system based on a user profile of the laboratory user, and based on the training credentials of the laboratory user, automatically assigning training material required for the laboratory user to use the laboratory system based on the training credentials of the laboratory user and the configuration file of the laboratory system and loading the assigned training material.

Abstract: An analyzer that has a simple configuration, that is inexpensive, that can improve safety, and that can inhibit proliferation of microorganisms using ultraviolet light is realized. A first electric power switch, a second electric power switch, and a third electric power switch are connected in series between an ultraviolet LED that irradiates an interior of a shared reagent storage container with ultraviolet light and a power supply that supplies electric power to the ultraviolet LED. The first electric power switch, the second electric power switch, and the third electric power switch are configured with two contact points and a connection section that connects and disconnects the two contact points. The first electric power switch is opened when a reagent storage door is opened, and the second electric power switch is opened in response to an action of extracting an ultraviolet irradiation section from a shared reagent storage container.

Abstract: A method to handle tubes in a diagnostic laboratory automation system comprising a control device and a tube-analyzing device is presented. The tube-analyzing device comprises a tube identification reader, a tube type recognition unit, a sample color determination unit, and a tube consistence unit. The tube identification reader reads tube identification device. The tube type recognition unit identifies tube type. The sample color determination unit determines sample color. The tube consistence unit determines sample consistency. The sample tube type, the tube type, the sample color, the sample consistency are send to the control device. The control device determines a construed tube type from one or more of the information of the tube type, the sample color, and the sample consistency. The control device checks whether the tube type matches the construed tube type and changes a used tube type from the tube type to the construed tube type.

Abstract: A container for receiving vessels for use in an automated analyzer is presented. The container comprises a wall assembly including a first wall and a second wall. The wall assembly forms a receptacle for receiving a vessel having one or more covers or lids. At least one of the first and second walls moves to provide a first open configuration for receiving the vessel and a second closed configuration. The container further comprises an actuator configured to translate the vessel from a first position after being received in the container to a second position and the wall assembly in the second closed configuration is positioned so that at least one engaging element attached to the wall assembly engages with the covers or lids of the vessel to open the covers or lids while the vessel is being translated by the actuator from the first position to the second position.

Abstract: An apparatus for determining a vertical position of at least one interface between a first component and at least one second component, the components comprised as different layers in a sample container. The apparatus comprises a first sensing unit and a first light detector configured to generate a first sensing signal, a second sensing unit comprising a second light detector configured to generate a second sensing signal, a driving unit configured to move the sample container, a position sensing unit configured to output a position sensing signal indicative of a vertical position of the sample container, a vertical position determining unit configured to match the first and the second sensing signal such that first and the second sensing signal correspond to identical vertical positions, and to determine the vertical position of the at least one interface in response to the matched sensing signals and the position sensing signal.

Abstract: The present disclosure relates to a method and a distribution system to move carriers on a transport plane. The distribution system comprises at least one first carrier and at least one second carrier, a transport plane comprising a number of moving positions, a drive device adapted to move each carrier to the moving positions, and a control device adapted to control the drive device. The control device plans moves for each carrier, checks the planned moves and plans new moves if required before the carriers are moved on the transport plane.

Abstract: The present disclosure relates to a laboratory sample container carrier handling apparatus comprising a revolving device, being adapted to move a sample container carrier supplied to the revolving device along a circular path P, and wherein the circular path P has at least one ascending ramp. The present disclosure relates further to a laboratory sample distribution system comprising such a laboratory sample container carrier handling apparatus.