Abstract: A bodily fluid sampling device includes a piercing device and a sensor enclosed in a housing. A cassette, which contains test media, is positioned proximal to the sensor so that the sensor is able to analyze a bodily fluid sample collected on the test media. The cassette includes a supply portion from which unused test media is supplied and a storage portion in which contaminated test media is stored after exposure to the bodily fluid. The cassette is adapted to collect a series of bodily fluid samples without requiring disposal of the test media.

Abstract: Exemplary protective barriers may be provided that house at least a portion of a medical device to prevent contamination of the medical device when it is used for treatment or testing. The protective barriers are removable from the medical device after use so that disinfection of the medical device is not required.

Abstract: Disclosed is a method aiding in the assessment of squamous cell carcinoma (SCC). It involves the use of the protein serpin B13 as a marker of SCC. Furthermore, the disclosure relates to a method for assessing lung cancer in a tissue sample derived from a patient having non-small cell lung carcinoma (NSCLC) and for differentiating SCC from adenocarcinoma or large cell carcinoma of the lung.

Abstract: A device and method of providing instruction to a patient regarding the dosing of insulin is provided.

Abstract: Analysis system for automatically performing a skin prick analysis by pricking the skin for producing a sample of body liquid and detecting an analyte contained in the sample. The analysis system comprises a magazine with a plurality of compartments each containing a lancing element and an analysis element, and a reusable hand-held instrument having a drive assembly. The drive assembly is adapted for driving at least the following movements by manually generated mechanical force: a coupling movement by which one of the lancing elements is coupled to the drive assembly; a puncturing and sample collection movement of one of the lancing elements contained in the magazine and coupled to the drive assembly; and a remaganizing movement by which the test element is transported back into the compartment of the magazine.

Abstract: The invention relates to an analytical test element for analysis of a liquid sample. The analytical test element may contain a channel which is suitable for capillary transport of the liquid sample and which is provided with an inlet opening for the liquid sample and with an air outlet opening. At least one test field may be arranged in the channel, spaced apart from the inlet opening. The test element comprises a sample application site which is closed with a seal and which is designed in such a way that, when the seal is opened, the sample application site and the inlet opening of the channel are simultaneously open to the outside environment of the test element. The test element can then receive the liquid sample inside the channel via the sample application site and inlet opening, for analysis in the test field. The invention also relates to a test element magazine and to a system for analysis of liquid samples with at least one test element.

Abstract: A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper end of the capillary tube for receiving the fluid. An absorbent pad can be disposed between the test strip and capillary tube for spreading-out the fluid being transferred to the test strip. An on-site analyzer such as an optical analyzer and/or an electrochemical analyzer can be mounted in the device for analyzing the fluid. Alternatively, a test strip can be slid through a slot formed in the bottom end of the device so that by passing the device against the skin after an incision has been formed, the test strip will directly contact body fluid emanating from the incision.

Abstract: The present disclosure relates to the field of laboratory diagnostics. The present disclosure provides means and methods for differentiating between an acute circulatory event and an ischemic event, as the cause underlying an acute medical event of a patient.

Abstract: The invention discloses the cloning, expression and uses of a chimeric fusion protein with superior chaperone and folding activities compared to the wild type chaperones. This invention relates to a chimeric fusion protein encoded by a recombinant DNA molecule containing nucleotide sequences coding for a polypeptide binding segment of a non-human chaperone protein and nucleotide sequences coding for an FK506 binding protein (FKBP) or an FK506-binding-protein-like domain (FKBP-like domain).

Abstract: An integrated test element (110) is proposed for detecting for detecting at least one analyte in a sample (142), in particular in a liquid sample (142). The integrated test element (110) has a carrier element (112), with an application face (114) on which at least one organic electroluminescent component (126) is applied. Furthermore, at least one indicator substance (136) is applied on the application face (114), which indicator substance (136) alters at least one optical characteristic, in particular an emission characteristic (e.g. a fluorescence characteristic), when it comes into contact with the at least one analyte. Furthermore, the integrated test element (110) has at least one photodetector element (116).

Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and ?l-range comprises a substrate with and open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.

Abstract: A system is disclosed wherein a graphical representation of a profile may be adjusted to adjust one or more values of the profile. The profile may includes data values corresponding to respective time periods. The data values being represented by data representations in the graphical representation. A non-contiguous grouping of the data representations may be selected by an operator to adjust the data values of the profile corresponding to the non-contiguous grouping of data representations. A contiguous grouping of the data representations may be selected by an operator to adjust the data values of the profile corresponding to the non-contiguous grouping of data representations.

Abstract: The present invention provides improved media for the cultivation of Clostridium histolyticum and culture supernatants for the biotechnological production of collagenase enzymes. The nutrient media according to the invention comprise one or more peptones from a non-mammalian source, preferably plant-derived peptones. The media can additionally comprise fish gelatin. The invention provides media, culture supernatants comprising Clostridium histolyticum collagenase, and methods to produce said collagenase.

Abstract: A method and system for calculating daily weighted averages of glucose measurements (or derived quantities) with time-based weights are disclosed. The present invention computes an average daily glucose value using the time based weights based on only consecutive glucose measurements in the plurality of glucose measurements with acceptable time intervals that do not exceed a predefined maximum time interval. The invention further relates to a computer program for implementing the method for calculating daily weighted averages of spot monitoring glucose measurements (or derived quantities) with the time-based weights.

Abstract: A reagent kit is provided comprising a plurality of containers with top-side openings, a common support structure or a plurality of support structures associated to the containers, and a plurality of caps. Each container and cap is mountable or provided on the common or the associated support structure, wherein each cap is formed essentially rectangular, having two shorter edges and two longer edges, and comprises: a cap body, a lid hinged to the cap body so to pivot around a pivot axis at least between closed and opened positions, the pivot axis being essentially parallel to the shorter edges. The containers and associated caps are arranged in a row along a connecting line such that the pivot axes are orthogonal to the connecting line. For at least one of the containers, an end portion of the cap body opposite to the pivot axis is not covered by the lid.

Abstract: A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper end of the capillary tube for receiving the fluid. An absorbent pad can be disposed between the test strip and capillary tube for spreading-out the fluid being transferred to the test strip. An on-site analyzer such as an optical analyzer and/or an electrochemical analyzer can be mounted in the device for analyzing the fluid. Alternatively, a test strip can be slid through a slot formed in the bottom end of the device so that by passing the device against the skin after an incision has been formed, the test strip will directly contact body fluid emanating from the incision.

Abstract: A portable measuring system which analyzes a liquid sample for at least one analyte. The portable measuring system has a substantially moisture-proof housing with an internal atmosphere. The housing prevents moisture from the air and water vapor from penetrating into the housing. The portable measuring system also has at least one test element support inserted into the internal atmosphere of the housing. The test element support is equipped with a retaining structure and a test element that is supported by the retaining structure. The test element support is designed such that, after insertion into the internal atmosphere, the test element is exposed to the internal atmosphere. A release mechanism is also provided which can convey at least one test element into an application position within the internal atmosphere of the housing. In this application position, the liquid sample can be applied to the test element.

Abstract: The present invention provides a puncturing system for withdrawing body fluid. The puncturing system comprises a disposable puncturing unit, which includes a needle element for piercing into skin and a puncturing depth reference element with a skin contact area. The system includes a puncturing instrument which has a puncturing drive, wherein the puncturing drive is coupled by a coupling mechanism to the puncturing unit for driving the needle element to a puncturing depth, the puncturing depth being determined by the distance in the piercing direction between the skin contact area and the position of the tip of the needle at a reversal point of the puncturing movement. The puncturing depth reference element is connected to the needle element such that the puncturing depth reference element moves with the needle element during at least part of the puncturing movement.

Abstract: An insulin pump configuration programming approach is disclosed that permits setting parameters of pump configuration files to invalid values. An operator may continue with the programming workflow after setting the invalid value. The configuration file including the invalid value may be saved to a memory location of a computing device, but cannot be saved to the pump. Invalid item icons are presented when a parameter is set to an invalid value, and instructions for correcting the invalidity condition are provided when an invalid item icon is hovered over using a pointing device.

Abstract: The present invention relates to lancet device by which a lancet is displaceable along a piercing path to generate a piercing wound in a skin surface, in particular to obtain body fluid for diagnostic purposes. To achieve performance of a piercing movement which is low in noise and shock, the lancet drive may include a control unit for regulating the piercing depth of the lancet and the lancet may be implemented to oscillate freely out in the piercing direction without delimitation by a mechanical piercing depth stop.