Abstract: A method for multiple transition monitoring using a liquid chromatography mass spectrometry device is disclosed and comprises determining at least one data set from at least one data base, the data set comprising at least one reference measurement of at least one transition of at least one analyte with the liquid chromatography mass spectrometry device; determining at least one reference peak information of the transition of the analyte using an initial setting of a measurement window, wherein the measurement window is defined by a time frame of retention times; determining an actual setting of the measurement window considering the reference peak information, wherein the determining comprises adjusting the time frame; measuring the transition of the analyte with the liquid chromatography mass spectrometry device and determining a measured peak information of the transition of the analyte using the actual setting of the measurement window.