Abstract: Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
Type:
Grant
Filed:
November 7, 2005
Date of Patent:
January 6, 2009
Assignee:
Roche Madison Inc.
Inventors:
Jon A. Wolff, James E. Hagstrom, Hans Herweijer, Vladimir G. Budker, Julia Hegge
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