Patents Assigned to Roche Molecular Systems
  • Patent number: 12147479
    Abstract: A computer-implemented method is provided. The method comprises: receiving, from a text field of a user interface, input text strings containing medical data; identifying, based on language semantics and grammatical structure, a keyword and one or more data values from the input text strings; providing the keyword as an input to a query of a medical data category database to obtain one or more categories associated with the keyword, the one or more categories including a first category; retrieving, from a template database, a first template associated with the first category, the first template including one or more fixed blocks and one or more variable blocks; inserting a data value corresponding to the keyword into a variable block of the first template to generate a replacement text string; and displaying the replacement text string in place of the input text strings in the text field.
    Type: Grant
    Filed: July 20, 2023
    Date of Patent: November 19, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Craig Atkinson
  • Publication number: 20240345115
    Abstract: In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.
    Type: Application
    Filed: April 29, 2024
    Publication date: October 17, 2024
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Michael Thomas NGUYEN, Sean FORD, Nikolas James HANSEN
  • Patent number: 12109568
    Abstract: The present invention describes a secondary tube tray for use in an automated processing system, the tray comprising a base module and a secondary tube insert. Furthermore, the present invention describes a secondary tube handling module of an automated processing system for automatically processing biological sample, and a method of handling secondary tubes for use in automatically processing biological sample in an automated processing system.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: October 8, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Lawrence Chiu, Reiner Hitt, Raphael Haag, Erich Caflisch, Nicolas Lehner
  • Patent number: 12103007
    Abstract: The present invention describes a base module (100) and a tray insert (200, 300, 400) of a multipurpose tray (100) for an automated processing system, such as an analytical, pre-analytical or post-analytical processing system, as well as to a multipurpose tray comprising such base module and such tray insert, wherein the tray insert can be particularly used for holding a plurality of reagent or sample tubes to be processed in the automated processing system. The present invention further relates to a method of simplified loading/unloading of such a multipurpose tray into/from the automated processing system.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: October 1, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Lawrence Chiu, Ion Iordanoaia, Reiner Hitt, Vijay Namasivayam, Eduard Nawrocki, Michael Neugebauer, Tim Moulton, Sam Palmer, Gerd Schmieta
  • Publication number: 20240311699
    Abstract: A machine learning model for traversing a decision tree, the machine learning model trained from a structured data set including a first set of key-value pairs and subject-specific criteria using the key-value pairs. The first set of key-value pairs is transformed into a second set of key-value pairs, which are projected to a subject-specific point within a multi-dimensional space. The decision tree includes decision and leaf nodes. Each leaf node is connected to a root node via a leaf-node-specific trajectory. Each decision node corresponds to a criterion using a value in the second set of key-value pairs. For each leaf node, a leaf-node-specific point within the multi-dimensional space is determined using the leaf-node-specific trajectory, and a similarity score is determined using the leaf-node-specific and subject-specific points. A subset of the leaf nodes is identified using the scores. State or protocol information for each leaf node in the subset is retrieved.
    Type: Application
    Filed: May 24, 2024
    Publication date: September 19, 2024
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Charles Alcorn, Alexander Wu, Wei Yao, Ju Zhang
  • Patent number: 12085578
    Abstract: A gripper system includes: a first gripper finger having a first groove, a second groove, and a third groove; and a second gripper finger having a first groove, a second groove, and a third groove, wherein the gripper is configured to apply a first compression force against length edges of a slide in a widthwise direction at the first grooves, the gripper is configured to apply a second compression force against width edges of the slide in a lengthwise direction at the second grooves, the gripper is configured to apply a third compression force against width edges of the slide in a lengthwise direction at the third grooves, and the third compression force against the width edges of the slide in the lengthwise direction is an orientation in which the slide is rotated perpendicular to an orientation corresponding to a gripping position of the second grooves.
    Type: Grant
    Filed: August 17, 2023
    Date of Patent: September 10, 2024
    Assignees: Ventana Medical Systems, Inc., Roche Molecular Systems, Inc.
    Inventors: Megan E. Creasey, Matthew D. Mette, Denny Osswald, James E. Phillips-Portillo, Clayton Reynolds, Curtis C. Rose, Alexander Schmelzer, Franklin R. Ventura
  • Patent number: 12073342
    Abstract: An informatics platform provides an architecture to integrate information from relevant patient information systems.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: August 27, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Michael Barnes, Stephen Burnell, William Evans, Weng Chi Lou, Mark M. Morita, Oluwatosin Oyeniran, Joseph Perez-Rogers, Joachim Schmid
  • Patent number: 12066311
    Abstract: The present disclosure provides for a sensor system for determining a flow rate of a fluid flow within a fluid channel comprising an elastic segment arranged next to a rigid segment, wherein a first pair of electrodes is provided at the rigid segment and a second pair of electrodes is provided at the elastic segment of the fluid channel. The system further comprises a sensor unit for detecting a capacitance of the first and second electrode pairs, and a processing unit for calculating and monitoring a distance between the electrodes of the second electrode pair based on the detected capacitance of the first electrode pair and the second electrode pair, wherein the first electrode pair is in contact with the rigid segment and the second electrode pair is in contact with the elastic segment. Moreover, a respective method for determining a flow rate of a fluid flow within a fluid channel is provided by the present disclosure, as well as a use of the sensor system.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: August 20, 2024
    Assignee: Roche Molecular Systems, Inc
    Inventors: Sven Ebert, Michal Karol Dobrzynski, Paul Federer, Arnulf Staib, Lukas Schneider
  • Patent number: 12048931
    Abstract: The present invention is directed to a foldable transport container suitable to receive and hold multiple plates with samples in it. The container is comfortable to load, transport and unload. The invention also relates to a strip of material for providing such a foldable transport container. Finally the invention relates to a method for assembling such a foldable container.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: July 30, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Erich Stiess, Sylvia Dobroszczyk, Jie Pu, Alexander Gaier
  • Patent number: 12043851
    Abstract: Disclosed are DNA polymerases having improved ability to incorporate methylated-dNTPs, relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases. Further disclosed are kits and reaction mixtures comprising the improved DNA polymerases as well as methods of primer extension using the improved DNA polymerases.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: July 23, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith A. Bauer, Barbara Eckert
  • Patent number: 12036552
    Abstract: The present disclosure relates to a method for isolating a biological target material from a liquid sample in a multiwell plate using magnetic particles, wherein high efficiency and low elution volumes are achieved by specific movements of the multiwell plate and a magnetic separation plate in relation to each other. Also disclosed is a pre-analytical system suitable for carrying out the method.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: July 16, 2024
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Stephan Korner, Emad Sarofim, Goran Savatic, Marko Simic
  • Patent number: 12018338
    Abstract: Methods for the rapid detection of the presence or absence of Trichomonas vaginalis (TV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target TV gene, along with kits are provided that are designed for the detection of TV.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: June 25, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jody Harris, Shi-Da Y. Lu, Kalyani Mangipudi, Jingtao Sun
  • Patent number: 12013407
    Abstract: The present invention describes a laboratory system for automatically processing at least one sample container containing a biological sample, the laboratory system comprising a housing; laboratory instrument units for executing processing steps on the biological sample; an input station configured to receive the sample container; a transport means for transport of the sample container from the input station to the laboratory instrument units, and further to an output station; a control unit for determining whether the sample and/or the container is in a condition to be processed by the laboratory instrument units; an input-output station providing an interface between the inside and the outside of the housing; and a workbench on the outside of the housing in front of the input-output station for an operator to be in the position to manipulate the sample and/or the container.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: June 18, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Andreas Gisler, Mike Mohns, Vijay Namasivayam, Maren Christin Wolff, Devorah Klein, Tim Moulton, Sam Palmer, Eric Saperstein
  • Patent number: 12013318
    Abstract: The present disclosure relates to a composition and its use for treating a sputum sample suspected to contain mycobacteria. The composition comprises thymol, a linear or branched alcohol, a chaotropic agent, a reducing agent, a detergent, and a buffer, and has a pH value between 8.5 and 10. Also disclosed is a method for treating a sputum sample suspected to contain mycobacteria.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: June 18, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Carolin Bier, Stefan Lange, Pirmin Hans Loetscher
  • Patent number: 12005439
    Abstract: A microfluidic device for thermocycling of a reaction mixture is provided. The device comprises an inlet opening, an outlet opening, a flow channel connecting the inlet opening and the outlet opening and defining a flow direction from the inlet opening through the flow channel to the outlet opening, wherein the flow channel comprises a first flow channel surface and a second flow channel surface opposite to the first flow channel surface, and an array of wells provided in the first flow channel surface for fluidic communication with the inlet opening and the outlet opening. Further, the first flow channel surface provides a first hydrophilicity and at least a part of the second flow channel surface provides a second hydrophilicity, wherein the first hydrophilicity is greater than the second hydrophilicity.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 11, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Alexander Meier, Chris Steinert, Michael Zeder
  • Patent number: D1036458
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: July 23, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Charles Alcorn, Celia Bel, Fernando Garcia-Alcalde, Marie Elisabeth Stobbe Kammersgaard, Enrique Vidal Ocabo, Ju Zhang
  • Patent number: D1049419
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: October 29, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Maximilian Ruhstorfer, Christian Thalmann, Adnan Wahid William Aksoy
  • Patent number: D1049421
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: October 29, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Maximilian Ruhstorfer, Christian Thalmann, Adnan Wahid William Aksoy
  • Patent number: D1050481
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: November 5, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Maximilian Ruhstorfer, Christian Thalmann, Adnan Wahid William Aksoy
  • Patent number: D1050483
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: November 5, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Maximilian Ruhstorfer, Christian Thalmann, Adnan Wahid William Aksoy