Abstract: DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase are provided. The polymerases are useful in a variety of primer extension methods. Also provided are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
Type:
Grant
Filed:
December 5, 2012
Date of Patent:
July 14, 2015
Assignee:
Rocher Molecular Systems, Inc.
Inventors:
Keith Bauer, Thomas W. Myers, Shawn Suko