Abstract: An underreamer drill hammer comprising a canister including a housing having an outer diameter, a proximal end configured for attachment to a drill string, and a percussive drill hammer housed within the housing, the percussive drill hammer having a drill bit movable between a radially retracted position and a radially extended position. The drill bit can rotate and is designed in a manner that the drill bit head cams, pivots, or swings out to a larger cutting diameter when the system is rotated in a first direction. The system is rotated in a second direction to retract the bit heads. The bits are retracted to remove the canister from the casing or to drill a smaller diameter hole through rock.

Abstract: An underreamer drill hammer comprising a canister including a housing having an outer diameter, a proximal end configured for attachment to a drill string, and a percussive drill hammer housed within the housing, the percussive drill hammer having a drill bit movable between a radially retracted position and a radially extended position. The drill bit can rotate and is designed in a manner that the drill bit head cams, pivots, or swings out to a larger cutting diameter when the system is rotated in a first direction. The system is rotated in a second direction to retract the bit heads. The bits are retracted to remove the canister from the casing or to drill a smaller diameter hole through rock.

Abstract: ProTGF?1-GARP complex-selective antibodies, polynucleotides capable of encoding the proTGF?1-GARP complex-selective antibodies or antigen-binding fragments, cells expressing proTGF?1-GARP complex-selective antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled proTGF?1-GARP complex-selective antibodies or antigen-binding fragments may be used to enhance an immune response in a subject, for example, against a cancer.

Abstract: A down-the-hole hammer comprising a housing and a drill bit disposed about a distal end of the housing. The drill bit includes a head, a shank extending from the head, the shank including a bore having a plurality of ribs, and an exhaust tube configured to be coupled to the shank, the exhaust tube including a plurality of ribs for engaging the counterbore of the shank.

Abstract: A down-the-hole drill hammer comprising a housing, a backhead connected to the housing, an accumulator housed within the housing and downstream the backhead, and a piston reciprocally mounted within the housing. The accumulator includes an accumulator housing, a liner within the accumulator housing, and a flexible diaphragm circumscribing the liner and within the accumulator housing.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: A down-the-hole drill hammer comprising a casing having externally threaded distal end, and a chuck having internal threads threadedly connectable to the distal end of the casing. The down-the-hole drill hammer further comprising a drill bit having a head and a shank extending proximally from the head, and a bit retaining ring between the casing and the chuck for releasably retaining the drill bit.

Abstract: A method for generating a rebounding motion between a person and a surface includes the steps of providing a rebounding device comprising front and rear members and a spring mechanism therebetween and moving the front member and the rear member toward and away from one another via the spring mechanism.

Abstract: Systems and methods are described for providing empathy corrections and predictions to various communications. In some aspects, a method may include obtaining training data to train a plurality of empathy correction models, where the training data is obtained through empathy games that elicit labels indicating an empathy score for individual statements and indicating at least one empathy characteristic upon which the empathy score is based. At least one statement from a communication platform may be obtained and an empathy score may be determined for statement using the empathy corrections models. The empathy score may be compared to an empathy threshold, and if the empathy score is below the empathy threshold, at least one correction to the statement may be determined to improve empathy of the first empathy characteristic, using the plurality of empathy correction models. The correction may then be provided to the communication platform.

Abstract: Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGF? and/or LTBP3-TGF?. The application also provides methods of use of these inhibitors for, for example, inhibiting TGF? activation, and treating subjects suffering from TGF?-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGF? inhibitor for a subject in need thereof are also provided.

Abstract: A rebounding device includes a front member, a rear member, and a spring mechanism including a first biasing element and force adjustment assembly. The force adjustment assembly includes a spring element including a front planar surface and a rear planar surface connected at a rounded portion, wherein the front planar surface contacts an inner surface of the front member; a screw housing secured to an inner surface of the rear member, wherein the screw housing includes a longitudinal channel and a bore on an upper surface; a drive screw positioned through the bore and along the longitudinal channel of the screw housing; a threaded block positioned within the longitudinal channel of the screw housing, wherein the threaded block is configured to move vertically along the longitudinal channel, and wherein the rear planar surface of the spring element is secured to the threaded block.

Abstract: A lowering assist device includes first and second track housings, first and second resistance mechanisms, and first and second platforms. Each track housing includes a front face, a rear face, and opposing side faces and further includes an internal shaft and an internal member vertically movable along the internal shaft. Each resistance mechanism is housed within the respective track housing and is configured to provide a biasing force to the respective internal member as the respective internal member moves within the respective track housing. Each platform is mounted to the respective internal members.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: A down-the-hole drill hammer including a drill bit about a distal end of the hammer and a piston for percussively contacting the drill bit. The drill hammer further includes a valve assembly for supplying and exhausting drive fluid to and from the piston, the valve assembly having a valve housing in fluid communication with drive fluid supply ports, drive ports and exhaust ports, and a control valve movable within the valve housing and in fluid communication with the valve housing. The drill hammer further includes a piston follower valve unconnected to the piston movable within the control valve for controlling positioning of the control valve and pressures applied to the piston via the drive ports and exhaust ports.

Abstract: The present invention relates to antibodies that specifically bind pro-myostatin and/or latent myostatin, and methods and uses thereof.

Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.

Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.

Abstract: A rebounding device includes a front member, a rear member, and a spring mechanism including a first biasing element and force adjustment assembly. The force adjustment assembly includes a spring element including a front planar surface and a rear planar surface connected at a rounded portion, wherein the front planar surface contacts an inner surface of the front member; a screw housing secured to an inner surface of the rear member, wherein the screw housing includes a longitudinal channel and a bore on an upper surface; a drive screw positioned through the bore and along the longitudinal channel of the screw housing; a threaded block positioned within the longitudinal channel of the screw housing, wherein the threaded block is configured to move vertically along the longitudinal channel, and wherein the rear planar surface of the spring element is secured to the threaded block.

Abstract: An instrument tray is configured for use with surgical and/or other invasive or non-invasive medical procedures, such as in operating rooms or ICU rooms within a hospital, for example. The tray facilitates a safe transfer of instruments between a procedural team and performing the procedure. In an embodiment the surgical tray may be attached directly to the patient and/or patient's drapes so that the tray may rest upon the patient.

Abstract: Disclosed herein are immunoglobulins, such as antibodies, and antigen binding portions thereof, that specifically bind complexes of GARP-TGF?1, LTBP1-TGF?1, LTBP3-TGF?1, and/or LRRC33-TGF?1. The application also provides methods of use of these immunoglobulins for, for example, inhibiting TGF?1 activity, and treating subjects suffering from TGF?1-related disorders, such as cancer and fibrosis.