Patents Assigned to Rohto Pharmaceutical Co., Ltd.
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Patent number: 11813299Abstract: The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.Type: GrantFiled: May 15, 2018Date of Patent: November 14, 2023Assignees: TSUBOTA LABORATORY, INC., ROHTO PHARMACEUTICAL CO., LTD.Inventors: Kazuo Tsubota, Toshihide Kurihara
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Publication number: 20230321058Abstract: The first aspect of the present invention relates to an ophthalmic composition comprising (A) one or more kinds selected from the group consisting of terpenoid, a tocopherol, and a benzyl ammonium compound and a salt thereof, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin. The second aspect of the present invention relates to an ophthalmic composition comprising (A2) a surface active component and (B2) a buffer, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.Type: ApplicationFiled: April 12, 2022Publication date: October 12, 2023Applicant: Rohto Pharmaceutical Co., Ltd.Inventor: Yasuko Matsumura
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Publication number: 20230285564Abstract: The present invention relates to an aqueous composition comprising delgocitinib or a salt thereof (A) and at least one selected from the group consisting of edetic acid, creatinine, and a salt thereof (B).Type: ApplicationFiled: July 30, 2021Publication date: September 14, 2023Applicant: Rohto Pharmaceutical Co., Ltd.Inventors: Ozora Kubo, Saeko Hayashi, Akiko Kita
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Publication number: 20230285562Abstract: The present invention relates to an aqueous composition comprising delgocitinib or a salt thereof (A) and at least one selected from the group consisting of citric acid, phosphoric acid, and a salt thereof (B).Type: ApplicationFiled: July 30, 2021Publication date: September 14, 2023Applicant: Rohto Pharmaceutical Co., Ltd.Inventors: Ozora Kubo, Saeko Hayashi, Akiko Kita
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Publication number: 20230277595Abstract: The present invention aims to provide a prophylactic and/or therapeutic agent for diabetes that is highly effective on diabetes developed as a side effect from immune checkpoint inhibitors and has a certain effect on many patients. The present invention is a therapeutic agent for diabetes comprising mesenchymal stem cells. The prophylactic and/or therapeutic agents for diabetes of the present invention are suitably used particularly for diabetes caused by immune checkpoint inhibitors and diabetes caused by anti-PD-1 antibody or anti-PD-L1 antibody.Type: ApplicationFiled: February 9, 2022Publication date: September 7, 2023Applicants: ROHTO PHARMACEUTICAL CO., LTD., OSAKA UNIVERSITYInventors: Shunbun KITA, Emi HORITANI, Norikazu MAEDA, Iichiro SHIMOMURA, Hiroyuki NISHIDA
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Patent number: 11707488Abstract: An object of the present invention is to provide novel mesenchymal stem cells demonstrating superior therapeutic effects against various diseases, a novel pharmaceutical composition containing these mesenchymal stem cells, and a method for preparing the same. The present invention relates to ROR1-positive mesenchymal stem cells. The ROR1-positive mesenchymal stem cells are preferably positive for CD29, CD73, CD90, CD105 and CD166 and are derived from umbilical cord or adipose tissue.Type: GrantFiled: August 29, 2016Date of Patent: July 25, 2023Assignee: ROHTO PHARMACEUTICAL CO., LTD.Inventors: Yoshifumi Ikeyama, Hiroyuki Nishida, Tomohiro Tsuda, Eiko Uno, Masayo Yumoto, Kazuma Suda, Mihoko Yoshino, Xuan Trung Ngo
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Publication number: 20230172969Abstract: The present invention relates to an ophthalmic composition for suppressing eye dryness, comprising at least one selected from the group consisting of chondroitin sulfate having a weight average molecular weight of 30,000 to 50,000 and a salt thereof.Type: ApplicationFiled: March 31, 2021Publication date: June 8, 2023Applicant: Rohto Pharmaceutical Co., Ltd.Inventors: Tatsuya Ando, Yoko Mitsuguchi, Sachiko Matsumoto, Atsuko Nakata
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Publication number: 20230158076Abstract: The present invention addresses the problem of providing a fundamental therapeutic method for renal diseases including glomerulonephritis such as IgA nephropathy. To solve this problem, the present invention pertains to an agent for increasing CD25-positive regulatory T cells in kidney, said agent comprising mesenchymal stem cells. The regulatory T cell-increasing agent of the present invention exerts a sufficient therapeutic effect even if further containing a cryopreservation liquid at a concentration of less than 5% (v/v).Type: ApplicationFiled: April 9, 2021Publication date: May 25, 2023Applicants: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, ROHTO PHARMACEUTICAL CO., LTD.Inventors: Shoichi MARUYAMA, Kazuhiro FURUHASHI, Akihito TANAKA, Munetoshi KARASAWA, Yukinari TAKAO
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Publication number: 20230094229Abstract: The present invention is a resin container having a multilayer structure including a first layer that comes into contact with liquid content and a second layer that is in contact with the first layer from an outer side of the first layer. The first layer includes a cyclic olefin copolymer and a linear low-density polyethylene resin, and the second layer includes a low-density polyethylene resin.Type: ApplicationFiled: October 21, 2019Publication date: March 30, 2023Applicant: Rohto Pharmaceutical Co., Ltd.Inventors: Hiroyuki Koshiro, Naohiro Ikeda
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Publication number: 20230101139Abstract: The present invention relates to an aqueous composition comprising delgocitinib or a salt thereof and having a pH of 4.0 to 6.5.Type: ApplicationFiled: December 25, 2020Publication date: March 30, 2023Applicant: Rohto Pharmaceutical Co., Ltd.Inventors: Akinori Nishimoto, Akiko Kita, Saeko Hayashi
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Publication number: 20230057222Abstract: An object of the present invention is to provide a new method for evaluating and/or screening an excellent healthcare material or pharmaceutical product based on a new concept. The present invention to solve the above object is a method for evaluating and/or screening a control agent for tissue morphology and/or tissue function, the method including: applying a test substance to a tissue or cell capable of expressing a mechanical stress signaling molecule; and evaluating expression, activity, or intracellular localization of the mechanical stress signaling molecule in the tissue or cell.Type: ApplicationFiled: October 19, 2020Publication date: February 23, 2023Applicants: ROHTO PHARMACEUTICAL CO., LTD., RIKENInventors: Shun KIMURA, Takashi TSUJI
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Publication number: 20230032293Abstract: Methods are described for treating a heart disease, comprising suspending c) mesenchymal stem cells in either a) a fibrinogen solution or b) a thrombin solution, thereby obtaining a cell suspension, and directly spraying the cell suspension on a disease site substantially at the same time with the other of a) the fibrinogen solution or b) the thrombin solution that is not used in the suspending.Type: ApplicationFiled: August 4, 2022Publication date: February 2, 2023Applicant: ROHTO PHARMACEUTICAL CO., LTD.Inventors: Yoshiki Sawa, Shigeru Miyagawa, Daisuke Kajita, Kotoe Tamada
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Publication number: 20220401300Abstract: The present invention is a resin container in which an inner wall surface of a container body includes a cyclic olefin copolymer, and a diameter upstream of an outlet of the container body ranges from 0.5 mm to 8.0 mm.Type: ApplicationFiled: October 21, 2019Publication date: December 22, 2022Applicant: Rohto Pharmaceutical Co., Ltd.Inventors: Naohiro Ikeda, Keita Kawai
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Publication number: 20220280515Abstract: The present invention relates to an ophthalmic composition for promoting tear secretion, the composition comprising 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile or a salt thereof.Type: ApplicationFiled: August 6, 2020Publication date: September 8, 2022Applicant: Rohto Pharmaceutical Co., Ltd.Inventors: Yoshihiro Takai, Takahiro Kurose
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Patent number: 11357798Abstract: The present invention relates to mesenchymal stem cell-derived microparticles having activity that promotes the growth of corneal epithelial stem cells and/or corneal epithelial cells, activity that maintains corneal epithelial stem cells in an undifferentiated state or promotes the formation of colonies thereby, and function that protects corneal epithelium.Type: GrantFiled: August 3, 2016Date of Patent: June 14, 2022Assignees: OSAKA UNIVERSITY, ROHTO PHARMACEUTICAL CO., LTD.Inventors: Kohji Nishida, Ryuuhei Hayashi, Yoichi Honma, Toru Okubo, Shun Shibata
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Patent number: 11331390Abstract: The first aspect of the present invention relates to an ophthalmic composition comprising (A) one or more kinds selected from the group consisting of terpenoid, a tocopherol, and a benzyl ammonium compound and a salt thereof, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin. The second aspect of the present invention relates to an ophthalmic composition comprising (A2) a surface active component and (B2) a buffer, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.Type: GrantFiled: April 21, 2017Date of Patent: May 17, 2022Assignee: ROHTO PHARMACEUTICAL CO., LTD.Inventor: Yasuko Matsumura
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Patent number: 11273437Abstract: Provided is a cell treatment apparatus that includes: an isolator; a disposal box that includes a storage part; and a decontamination unit, wherein the disposal box includes: a first opening and closing device that is configured to allow the isolator and the storage part to be communicated with each other at the time of disposal of the waste product and allow them to be shut off from each other after the putting-in of the waste product and before the disposal of the same; and a second opening and closing device that is configured to allow the storage part and the outside to be communicated with each other at the time of disposal of the waste product, which has been put into the storage part, and allow them to be shut off from each other after the disposal of the waste product.Type: GrantFiled: October 19, 2016Date of Patent: March 15, 2022Assignee: Rohto Pharmaceutical Co., Ltd.Inventors: Tetsuo Koike, Masahiro Takimoto, Yoshiki Yagi
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Patent number: 11253550Abstract: The purpose of the present invention is to provide a novel therapeutic agent for liver disease. The present invention is a mesenchymal stem cell characterized by high expression of the Tissue Factor Pathway Inhibitor (TFPI). It is preferable that the mesenchymal stem cell is allogeneic and is derived from a fatty tissue. Moreover, the present invention includes a therapeutic agent for liver disease containing the mesenchymal stem cell.Type: GrantFiled: February 22, 2018Date of Patent: February 22, 2022Assignee: ROHTO PHARMACEUTICAL CO., LTD.Inventors: Yui Ueno, Hidenori Nonaka
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Patent number: 11179420Abstract: An object of the present invention is to provide novel mesenchymal stem cells demonstrating superior therapeutic effects for various diseases, a novel pharmaceutical composition containing the mesenchymal stem cells, and methods for preparing these. The present invention provides mesenchymal stem cells expressing at least one cell surface marker selected from the group consisting of CD201, CD46, CD56, CD147 and CD165. The mesenchymal stem cells expressing such a specific marker are positive for CD29, CD73, CD90, CD105 and CD166, and maintain an undifferentiated state.Type: GrantFiled: April 27, 2017Date of Patent: November 23, 2021Assignee: ROHTO PHARMACEUTICAL CO., LTD.Inventors: Yoshifumi Ikeyama, Eiko Uno, Masayo Yumoto, Mihoko Yoshino, Xuan Trung Ngo, Hiroyuki Nishida, Akiko Uetani
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Patent number: 11166938Abstract: Provided is an external composition excellent in stability and impression from use. An external composition containing (A) at least one member selected from the group consisting of ascorbic acid and salts of ascorbic acid, (B) at least one member selected from the group consisting of 3-O-ethylascorbic acid, salts of 3-O-ethylascorbic acid, and hydroxylated lecithin, and (C) polyethylene glycol is prepared.Type: GrantFiled: June 28, 2017Date of Patent: November 9, 2021Assignee: ROHTO PHARMACEUTICAL CO., LTD.Inventors: Masatoshi Haga, Yuya Hayashi