Patents Assigned to Roman Perez-Soler
  • Lipid complexed topoisomerase I inhibitors
    Patent number: 5834012
    Abstract: The present invention is described as a lipid-complexed topoisomerase I inhibitor (TII), for example camptothecin (CPT) preparation that allows for intravenous administration in vivo in clinically relevant lipid:drug ratios. The lipid formulation has in vitro antitumor activity similar to that of the base compound and displays similar cytotoxicity against both MDR-1 negative and positive tumor cells.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: November 10, 1998
    Assignees: Roman Perez-Soler, Steven M. Sugarman, Kenneth R. Poirot
    Inventors: Roman Perez-Soler, Steven M. Sugarman, Kenneth R. Poirot
  • Anthracyclines with unusually high activity against cells resistant to doxorubicin and its analogs
    Patent number: 5625043
    Abstract: The present disclosure details novel modified anthracyclines, the synthesis thereof, and their use in treating patients with tumors. Preferred aspects of the disclosure involve modified anthracyclines which have an O-substituted aromatic ring on their sugar moiety. Other preferred aspects of the disclosure involve synthesis steps wherein a hydroxyl group on a sugar moiety to be added is blocked with a halo-substituted alkyl group during the process of adding it to an anthracycline ring compound.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: April 29, 1997
    Assignees: Waldemar Priebe, Piotr Skibicki, Roman Perez-Soler
    Inventors: Waldemar Priebe, Piotr Skibicki, Roman Perez-Soler