Patents Assigned to Rona Bioscience, Limited
  • PRODRUG FOR DELIVERING SIRNA INTO CELL
    Publication number: 20260176624
    Abstract: The present invention provides an oligonucleotide, containing a compound of formula (Ia), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The compound of formula (I) is contained inside the oligonucleotide or at the 5? terminal and/or the 3? terminal, and is used for improving the ability of double-stranded RNA to pass through a cell membrane. The present invention also relates to a double-stranded RNA, a cell, a pharmaceutical composition and a kit containing the oligonucleotide.
    Type: Application
    Filed: October 30, 2023
    Publication date: June 25, 2026
    Applicant: Rona Bioscience, Limited
    Inventors: Jinyu Huang, Hao Zou, Junkai Liu, Yang Ke
  • DOUBLE-STRANDED RNA COMPRISING NUCLEOTIDE ANALOG CAPABLE OF REDUCING OFF-TARGET TOXICITY
    Publication number: 20250388617
    Abstract: The present invention provides a double-stranded RNA comprising a nucleotide analog. The double-stranded RNA of the present invention exhibits one or more of enhanced stability, reduced off-target toxicity, and enhanced effectiveness.
    Type: Application
    Filed: June 26, 2023
    Publication date: December 25, 2025
    Applicant: Rona Bioscience, Limited
    Inventors: Jinyu Huang, Hao Zou, Hongli Guo
  • CYCLIC PHOSPHONATE-MODIFIED NUCLEOTIDE
    Publication number: 20250368675
    Abstract: The present invention provides an oligonucleotide having a cyclic phosphonate modification. The oligonucleotide of the present invention exhibits one or more among enhanced stability, reduced off-target toxicity, and enhanced effectiveness.
    Type: Application
    Filed: June 13, 2023
    Publication date: December 4, 2025
    Applicant: Rona Bioscience, Limited
    Inventors: Jinyu Huang, Hao Zou, Junkai Liu
  • TARGETING LIGAND CONTAINING N-ACETYLGALACTOSAMINE
    Publication number: 20250161461
    Abstract: Provided in the present invention is a ligand containing N-acetylgalactosamine, wherein the ligand contains a conjugated group as represented by formula (X?) and a nucleic acid molecule containing the targeting ligand.
    Type: Application
    Filed: January 29, 2023
    Publication date: May 22, 2025
    Applicant: Rona Bioscience, Limited
    Inventors: Jinyu Huang, Hongli Guo
  • DOUBLE-STRANDED RNA HAVING NUCLEOTIDE ANALOG
    Publication number: 20250074933
    Abstract: Provided in the present invention is a double stranded RNA having a nucleotide analog. The double-stranded RNA of the present invention shows one or more of enhanced stability reduced off-target toxicity and enhanced efficiency.
    Type: Application
    Filed: January 4, 2023
    Publication date: March 6, 2025
    Applicant: Rona Bioscience, Limited
    Inventors: Jinyu Huang, Hongli Guo