Abstract: This invention relates to imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds of the formula ##STR1## wherein A is CH or N and not more than one of W, X, Y and Z is a N atom which possess valuable pharmaceutical preparations, e.g., increasing cardiotonic contractility. Uses of said compounds including methods for increasing cardiac contractility and in the treatment of congestive heart failure, pharmaceutical compositions including the same and methods for the preparation thereof.
Type:
Grant
Filed:
July 22, 1987
Date of Patent:
February 21, 1989
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
William C. Faith, Henry F. Campbell, Donald E. Kuhla, William L. Studt, James L. Barnes
Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which are amide analogs of natural calcitonins.
Type:
Grant
Filed:
December 5, 1986
Date of Patent:
February 14, 1989
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Edward S. Neiss, David Stevenson, Laurence L. Ho, Robert C. Liu, John T. Suh
Abstract: Disclosed are aqueous multivitamin/trace elements formulations stabilized by a water soluble, organic acid that contains carbon-to-carbon unsaturation and water soluble salts thereof selected from the group consisting of maleic acid, fumaric acid, maleamic acid and acrylic acid.
Type:
Grant
Filed:
February 8, 1988
Date of Patent:
February 14, 1989
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Morris Kesselman, Abdur R. Purkaystha, James Cahill
Abstract: Compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein: Ar is phenyl, naphthyl, heteroaryl, indole, or fused arylcycloalkyl optionally substituted with hydroxy, halo, CF.sub.3, NO.sub.2, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or aryloxy;A and A' are each hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy or aryloxy;X is cyano, nitro, COOR, SR, SOR or SOOR;R is H, C.sub.1-6 alkyl or aryl;n n' and n" are each 0 to 4; andm, m' and m" are each 1 to 4, have calcium channel blocking activity.
Type:
Grant
Filed:
November 20, 1986
Date of Patent:
January 3, 1989
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
John R. Regan, Jeffrey N. Barton, John T. Suh, Jerry W. Skiles
Abstract: This invention relates to new lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties. The present new compounds are of the formula: ##STR1## and salts thereof; wherein, R is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower aralkyl, phenyl, naphthyl, or a nitrogen oxygen or sulfur heterocyclic; andY.sub.1 and Y are independently hydrogen, lower alkyl, hydroxy, lower alkoxy, aryloxy, lower aralkoxy, aryl, lower aralkyl, carboxy, lower carbalkoxy, lower carbaralkoxy, carbaryloxy, formyl, or alkyl, alkenyl or alkynyl containing up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms;provided that when Y and Y.sub.1 are both hydrogen or when Y.sub.1 is hydrogen and Y is CHO, the R is other than hydrogen, unsubstituted phenyl, or lower alkyl.
Abstract: This invention relates to new chemical compounds possessing valuable pharmaceutical activity, particularly as lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties.
Abstract: A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
February 26, 1988
Date of Patent:
November 29, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt
Abstract: This invention relates to 6-pyridone-carbostyril compounds, uses of said compounds, including methods for increasing cardiac contractility, pharmaceutical compositions including the same and methods for the preparation thereof.
Type:
Grant
Filed:
June 25, 1986
Date of Patent:
November 15, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Henry F. Campbell, Donald E. Kuhla, Bruce F. Molino, William L. Studt
Abstract: Benzodiazinone-pyridazinone and -hydroxypyrazolyl compounds possess cardiotonic activity and are included in therapeutic cardiotonic compositions useful in methods for increasing cardiac contractility and for the treatment of congestive heart failure.
Type:
Grant
Filed:
June 17, 1987
Date of Patent:
November 15, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt, William C. Faith, Bruce F. Molino
Abstract: Compounds of the formula ##STR1## wherein: Het is imidazol-1-yl or 1,2,4-triazol-1-yl;py is 2-, 3-, or 4-pyridyl;R and R.sub.2 are H or alkyl;R.sub.1 is H, alkyl or vicinal R.sub.1 groups from a C--C double bond; and x is 0 or 1;or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions including the same for cardiotonic uses and methods of treating congestive heart failure.
Type:
Grant
Filed:
October 23, 1985
Date of Patent:
November 8, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt, William C. Faith
Abstract: A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting parmacological activity, including anti-secretory and anti-ulcerogenic activity, pharaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
January 7, 1988
Date of Patent:
October 11, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt, Kent W. Neuenschwander
Abstract: A method of preparing von Willebrand Factor by disassociating it from a chaotropic agent in solution therewith and preferably treating the same under controlled temperature either in liquid or lyophilized form.
Abstract: Disclosed is a method for the treatment of allergic rhinitis that manifests itself as rhinorrhea, nasal itching, sneezing, congestion and postnasal drip. The method comprises the administration from a nasal aerosol dispenser an effective amount of micronized triamcinolone acetonide suspended in dichlorodifluoromethane into the nasal cavity of a patient suffering from allergic rhinitis.
Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 19, a glutamine in position 20, or a threonine in position 21. All three amino acids are omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
Abstract: This invention relates to substituted benzodiazinone-pyridone compounds and their use as cardiotonic agents including methods for increasing cardiac contractility, pharmaceutical compositions including the same and methods for the preparation thereof.
Type:
Grant
Filed:
August 27, 1986
Date of Patent:
August 16, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Bruce F. Molino, Henry F. Campbell, Donald E. Kuhla, William L. Studt
Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 19, a glutamine in position 20, a threonine in position 21, and a tyrosine in position 22. All four amino acids are omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
Type:
Grant
Filed:
April 21, 1987
Date of Patent:
August 16, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Ronald C. Orlowski, Jay K. Seyler, Everett Flanigan
Abstract: New hypocalcaemic peptides are disclosed of the formula ##STR1## wherein X represents acyl groups for the acylation of the N alpha-amino group and the radicals of carboxylic acids especially of formic, acetic, propionic, buteric, valeric, hexanoic, heptanoic, octanoic, and nonanoic acids along with all their respective isomers. We also wish to include L-lactic acid along with the half amides of malonic, succinic, glutaric and adipic acids.
Abstract: Compounds having the general structure ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are defined herein, which exhibit antihypertensive activity.
Type:
Grant
Filed:
July 8, 1985
Date of Patent:
June 7, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Edward S. Neiss, John T. Suh, John R. Regan, Jerry W. Skiles, Jeffrey N. Barton, James J. Mencel, Paul Menard
Abstract: A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcero-genic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Type:
Grant
Filed:
October 5, 1987
Date of Patent:
May 31, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Donald E. Kuhla, Henry F. Campbell, William L. Studt
Abstract: Compounds having the general structure ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are defined herein, which exhibit antihypertensive activity.
Type:
Grant
Filed:
September 12, 1984
Date of Patent:
May 24, 1988
Assignee:
Rorer Pharmaceutical Corporation
Inventors:
Edward S. Neiss, John T. Suh, John R. Regan, Jerry W. Skiles, Jeffrey N. Barton, Paul Menard