Abstract: Methods and systems are provided herein that are based on the effects of genetic variations on the biological activities associated to rostafuroxin in an individual. In particular, compositions, methods and systems are herein described that are based on an indentified influence on an individual response to rostafuroxin of one or more polymorphisms in an intergenic or intragenic region of a gene selected from the group consisting of KCNS3, THSD7A, FAM46A, LOC389970, HLA-G, and TTC29, and/or a genetic variation in linkage disequilibrium therewith.
Type:
Grant
Filed:
October 18, 2010
Date of Patent:
August 9, 2016
Assignee:
ROSTAQUO S.P.A.
Inventors:
Giuseppe Bianchi, Patrizia Ferrari, Fabio Macciardi
Abstract: New crystalline forms of 17?-(3-Furyl)-5-?androstane-3?,14?,17?-triol are described together with pharmaceutical composition containing the same and methods for their preparation. In particular new Forms B, C, D, E and H are here described.
Type:
Grant
Filed:
November 23, 2006
Date of Patent:
September 8, 2015
Assignee:
ROSTAQUO S.P.A.
Inventors:
Alberto Cerri, Silvia Armaroli, Marco Torri