Patents Assigned to ROTHAMSTED RESEARCH LTD.
  • Publication number: 20220282267
    Abstract: Described herein are non-human organisms for producing triacylglycerol wherein the non-human organism is genetically modified to express a lysophosphatidic acid acyltransferase specific for C16:0-Coenzyme A (C16:0 LPAT) and wherein, once expressed, the C16:0 LPAT is localised in the endoplasmic reticulum. Also described are non-human organisms for producing triacylglycerol in which (a) a lysophosphatidic acid acyltransferase specific for C16:0-Coenzyme A (C16:0 LPAT) is localised in the endoplasmic reticulum; and (b) activity of native endoplasmic reticulum lysophosphatidic acid acyltransferase (ER LPAT) is suppressed or prevented. Further described are non-human organisms in which a chloroplast lysophosphatidic acid acyltransferase (LPAT) is expressed, wherein said chloroplast LPAT lacks a functional chloroplast targeting signal. The disclosure also relates to methods for extracting triacylglycerol from the organisms and the use thereof in infant formula.
    Type: Application
    Filed: August 6, 2020
    Publication date: September 8, 2022
    Applicant: ROTHAMSTED RESEARCH LTD
    Inventors: Peter EASTMOND, Henricus Egbertus Gerardus VAN ERP, Govindprasad BHUTADA
  • Publication number: 20220105113
    Abstract: Described herein are compounds comprising a dimer of dehydrosalicortin or a derivative, homologue, stereoisomer, prodrug or pharmaceutical salt thereof. In particular embodiments, the dimer is a result of a Diels-Alder reaction. Also described are compositions comprising the compounds and their use in treating disease.
    Type: Application
    Filed: January 29, 2020
    Publication date: April 7, 2022
    Applicants: ROTHAMSTED RESEARCH LTD, UNIVERSITY OF KENT
    Inventors: Michael Henry BEALE, Jane Louise WARD, Yanqi WU, Martin MICHAELIS
  • Patent number: 10881631
    Abstract: A recombinant camelina plant or cell comprising one or more polynucleotides encoding a ?6-desaturase, a ?6-elongase and a ?5-desaturase operably linked with one or more regulatory sequences.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: January 5, 2021
    Assignee: ROTHAMSTED RESEARCH LTD.
    Inventors: Johnathan Napier, Olga Sayanova, Noemi Ruiz-Lopez, Richard Haslam
  • Publication number: 20180298401
    Abstract: Disclosed are plants including a cyanobacterial ribulose-1,5,-bisphosphate carboxylase/oxygenase (Rubisco) which can assemble and fix carbon without an interacting protein.
    Type: Application
    Filed: November 12, 2015
    Publication date: October 18, 2018
    Applicants: Cornell University, Rothamsted Research Ltd.
    Inventors: Maureen HANSON, Myat LIN, Martin Afan John PARRY
  • Publication number: 20160083738
    Abstract: The invention relates to eukaryotic organisms such as vascular plants that include recombinant microcompartments.
    Type: Application
    Filed: May 8, 2014
    Publication date: March 24, 2016
    Applicants: CORNELL UNIVERSITY, ROTHAMSTED RESEARCH LTD.
    Inventors: Maureen HANSON, Myat LIN, Martin Afan John PARRY
  • Publication number: 20150216828
    Abstract: A recombinant camelina plant or cell comprising one or more polynucleotides encoding a ?6-desaturase, a ?6-elongase and a ?5-desaturase operably linked with one or more regulatory sequences.
    Type: Application
    Filed: April 12, 2013
    Publication date: August 6, 2015
    Applicant: Rothamsted Research Ltd.
    Inventors: Johnathan Napier, Olga Sayanova, Noemi Ruiz-Lopez, Richard Haslam
  • Patent number: 8809389
    Abstract: A composition comprising an alkynyl phenoxy compound of Formula (I) as a synergist and a pesticidal active ingredient is described, wherein R1 and R2, similar or different, are (C1-C4)alkyl or R1O— and R2O— together represent a group —O—CH2—O—, —O—CH(CH3)—O, —O—CH2—CH2—O—, —O—CH2—CH2—, R3 is (C1-C6)alkyl, (C3-C6)alkenyl or —B—(CH2—CH2—O)z-R6 where B is —CH2—O— or —O—, z is 0, 1 or 2 and R6 is (C1-C4)alkyl; R4 is hydrogen or methyl; R5 is hydrogen or methyl; x is an integer from 1 to 2; y is 0, 1 or 2; with the proviso that when R3 is —B—(CH2CH2—O)z-R6, y is 1 and 5-(propargyloxy)-benzo[1,3]dioxole is excluded.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: August 19, 2014
    Assignees: Endura S.p.A., Rothamsted Research Ltd.
    Inventors: Valerio Borzatta, Elisa Capparella, Leni Moroni, Graham Moores, Despina Philippou
  • Patent number: 8785727
    Abstract: The present invention relates to a polynucleotide from Emiliana huxleyi which codes for a desaturase and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotide according to the invention, and to the polypeptides encoded by the polynucleotide. The invention furthermore relates to antibodies against the polypeptide according to the invention. Finally, the invention also relates to production methods for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: July 22, 2014
    Assignee: Rothamsted Research Ltd.
    Inventors: Joerg Bauer, Johnathan A. Napier, Olga Sayanova
  • Publication number: 20110189697
    Abstract: The present disclosure is relative to a method for the production of Very-Long-Chain Fatty Acids (VLCFA) into a plant cell, including culturing a recombinant plant cell in an appropriate medium, wherein said plant cell is transformed with an heterologous gene encoding for an hydroxyacyl-CoA dehydratase. The disclosure is also relative to a method for producing vegetable oil including high levels of VLCFA.
    Type: Application
    Filed: June 25, 2009
    Publication date: August 4, 2011
    Applicants: INSTITUTE NATIONAL DE LA RECHERCHE AGRONIMIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS, ROTHAMSTED RESEARCH LTD.
    Inventors: Jean- Denis Faure, Liën Bach, Martine Miquel, Johnathan Napier