Abstract: Described herein are non-human organisms for producing triacylglycerol wherein the non-human organism is genetically modified to express a lysophosphatidic acid acyltransferase specific for C16:0-Coenzyme A (C16:0 LPAT) and wherein, once expressed, the C16:0 LPAT is localised in the endoplasmic reticulum. Also described are non-human organisms for producing triacylglycerol in which (a) a lysophosphatidic acid acyltransferase specific for C16:0-Coenzyme A (C16:0 LPAT) is localised in the endoplasmic reticulum; and (b) activity of native endoplasmic reticulum lysophosphatidic acid acyltransferase (ER LPAT) is suppressed or prevented. Further described are non-human organisms in which a chloroplast lysophosphatidic acid acyltransferase (LPAT) is expressed, wherein said chloroplast LPAT lacks a functional chloroplast targeting signal. The disclosure also relates to methods for extracting triacylglycerol from the organisms and the use thereof in infant formula.
Type:
Application
Filed:
August 6, 2020
Publication date:
September 8, 2022
Applicant:
ROTHAMSTED RESEARCH LTD
Inventors:
Peter EASTMOND, Henricus Egbertus Gerardus VAN ERP, Govindprasad BHUTADA
Abstract: Described herein are compounds comprising a dimer of dehydrosalicortin or a derivative, homologue, stereoisomer, prodrug or pharmaceutical salt thereof. In particular embodiments, the dimer is a result of a Diels-Alder reaction. Also described are compositions comprising the compounds and their use in treating disease.
Type:
Application
Filed:
January 29, 2020
Publication date:
April 7, 2022
Applicants:
ROTHAMSTED RESEARCH LTD, UNIVERSITY OF KENT
Inventors:
Michael Henry BEALE, Jane Louise WARD, Yanqi WU, Martin MICHAELIS
Abstract: A recombinant camelina plant or cell comprising one or more polynucleotides encoding a ?6-desaturase, a ?6-elongase and a ?5-desaturase operably linked with one or more regulatory sequences.
Type:
Grant
Filed:
April 12, 2013
Date of Patent:
January 5, 2021
Assignee:
ROTHAMSTED RESEARCH LTD.
Inventors:
Johnathan Napier, Olga Sayanova, Noemi Ruiz-Lopez, Richard Haslam
Abstract: Disclosed are plants including a cyanobacterial ribulose-1,5,-bisphosphate carboxylase/oxygenase (Rubisco) which can assemble and fix carbon without an interacting protein.
Type:
Application
Filed:
November 12, 2015
Publication date:
October 18, 2018
Applicants:
Cornell University, Rothamsted Research Ltd.
Inventors:
Maureen HANSON, Myat LIN, Martin Afan John PARRY
Abstract: A recombinant camelina plant or cell comprising one or more polynucleotides encoding a ?6-desaturase, a ?6-elongase and a ?5-desaturase operably linked with one or more regulatory sequences.
Type:
Application
Filed:
April 12, 2013
Publication date:
August 6, 2015
Applicant:
Rothamsted Research Ltd.
Inventors:
Johnathan Napier, Olga Sayanova, Noemi Ruiz-Lopez, Richard Haslam
Abstract: A composition comprising an alkynyl phenoxy compound of Formula (I) as a synergist and a pesticidal active ingredient is described, wherein R1 and R2, similar or different, are (C1-C4)alkyl or R1O— and R2O— together represent a group —O—CH2—O—, —O—CH(CH3)—O, —O—CH2—CH2—O—, —O—CH2—CH2—, R3 is (C1-C6)alkyl, (C3-C6)alkenyl or —B—(CH2—CH2—O)z-R6 where B is —CH2—O— or —O—, z is 0, 1 or 2 and R6 is (C1-C4)alkyl; R4 is hydrogen or methyl; R5 is hydrogen or methyl; x is an integer from 1 to 2; y is 0, 1 or 2; with the proviso that when R3 is —B—(CH2CH2—O)z-R6, y is 1 and 5-(propargyloxy)-benzo[1,3]dioxole is excluded.
Type:
Grant
Filed:
August 18, 2010
Date of Patent:
August 19, 2014
Assignees:
Endura S.p.A., Rothamsted Research Ltd.
Abstract: The present invention relates to a polynucleotide from Emiliana huxleyi which codes for a desaturase and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotide according to the invention, and to the polypeptides encoded by the polynucleotide. The invention furthermore relates to antibodies against the polypeptide according to the invention. Finally, the invention also relates to production methods for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
Type:
Grant
Filed:
April 29, 2009
Date of Patent:
July 22, 2014
Assignee:
Rothamsted Research Ltd.
Inventors:
Joerg Bauer, Johnathan A. Napier, Olga Sayanova
Abstract: The present disclosure is relative to a method for the production of Very-Long-Chain Fatty Acids (VLCFA) into a plant cell, including culturing a recombinant plant cell in an appropriate medium, wherein said plant cell is transformed with an heterologous gene encoding for an hydroxyacyl-CoA dehydratase. The disclosure is also relative to a method for producing vegetable oil including high levels of VLCFA.
Type:
Application
Filed:
June 25, 2009
Publication date:
August 4, 2011
Applicants:
INSTITUTE NATIONAL DE LA RECHERCHE AGRONIMIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS, ROTHAMSTED RESEARCH LTD.