Abstract: The invention relates to vaccines, and particularly to vaccines active against pathogenic bacteria including Clostridia species, such as C. difficile, and Bacillus species, such as B. anthracis and B. cereus. The invention is concerned with the use of nucleic acids and proteins as antigens for use in vaccine design and construction, and to the vaccines per se. The nucleic acids and proteins are also useful in diagnostic test kits and methods for the detection of Clostridium spp. and Bacillus spp. infections.
Type:
Application
Filed:
April 14, 2015
Publication date:
December 3, 2015
Applicant:
Royal Holloway and Bedford New College, University of London
Abstract: Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.
Type:
Grant
Filed:
August 5, 2011
Date of Patent:
December 4, 2012
Assignee:
Royal Holloway and Bedford New College, University of London
Inventors:
Linda Popplewell, Ian Graham, John George Dickson
Abstract: Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.
Type:
Application
Filed:
August 5, 2011
Publication date:
March 15, 2012
Applicant:
Royal Holloway and Bedford New College, University of London
Inventors:
Linda Popplewell, Ian Graham, John George Dickson
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