Abstract: Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

Abstract: The present invention relates to a method of coating a spore with one or more therapeutic agents. The present invention also relates to a coated spore obtained by the method of the present invention and the use of the coated spore as a vaccine.

Abstract: Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

Abstract: Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

Abstract: A routing method for an ad hoc network is disclosed, the network comprising two or more nodes (A, B, C, D, E, F), and the method comprising: sending a message from a start node (A) to a finish node (F) via one or more intermediate nodes (B, C, D, E); each of the start node (A) and intermediate nodes (B, C, D, E) receiving an acknowledgement signal (AckB, AckC, AckD, AckE, AckF) from a one-hop neighboring node when the one-hop neighboring node receives the message from the start node (A;F) or intermediate nodes (B, C, D, E) and, in the case of the one-hop neighboring node not being the finish node (F), the start node and intermediate nodes receiving an acknowledgement signal (AckC, AckD, AckE, AckF) from a two-hop neighboring node when the two-hop neighboring node receives the message from the one-hop neighboring node.

Abstract: A broadcast control method includes validating a time and location of an end user device by verifying the identity and location of a device on the intermediary network; sending a nonce from a intermediary network to an end user device at a first time; sending the nonce from the end user to the network at a second time; sending an encrypted request for content from the network to a broadcast system; decrypting the request to verify the identities of the devices and the time and location data; and sending content from the broadcast system to the end user device if the identities are verified and the time interval between the first and second times is less than the predetermined time interval.

Abstract: The present invention is based on a Bacillus the spores and vegetative cells forms of which are a different colour because of differential presence of at least one carotenoid in the spore and vegetative cell forms of the Bacillus. The Bacillus may therefore be used in detection methods and biosensors. The Bacillus may also be used a colourant and a dye and in the generation of foods, food supplements, probiotic compositions, dyes, cosmetic, pharmaceuticals and vaccines. The Bacillus may also be used for the production of carotenoids, precursors thereof and downstream derivatives.

Abstract: An aim of the invention is to provide an authentication method which retains the advantages of the S/KEY system while offering improved resistance to host impersonation attacks.

Abstract: A screening device for use in scanning objects for security checking or medical observation includes an X-ray source providing two beams for projection at the object, a linear sensor array being provided for each beam whereby an intensity map and a motion map is generated to provide a data set from which a 3D image can be generated and viewed.

Abstract: A method of controlling transmission of broadcast content from a content provider via a broadcast means to an end user device using an intermediary network comprises validating the time and location of the end user device by verifying the identity and location of a device on the intermediary network; sending a nonce from a intermediary network to an end user device at a first time; sending the nonce from the end user to the network at a second time; sending an encrypted request for content from the network to the broadcast means; decrypting the request to verify the identities of the devices and the time and location data; and sending content from the broadcast means to the end user device if the identities are verified and the time interval between the first and second times is less than the predetermined time interval.

Abstract: A current sensing noise thermometer is described, in which a low noise amplifier is used to measure the noise current in a sensor resistor and the sensor resistor is connected in series with a superconducting coil, or a coil assembly including at least one superconductor. The superconductor of the coil assembly is preferably positioned inside the coil, and the superconducting transition temperature of the superconductor is used to calibrate the thermometer. Preferably, the sensor resistor is grounded to enable particularly low temperatures to be achieved.