Abstract: Methods are disclosed for generating, manipulating, and controlling non-Gaussian quantum states in continuous variable cluster quantum states usable for quantum computing. Some methods can be used to generate, transport, and enlarge Schrödinger-Cat states embedded in the CV cluster quantum state. Some methods can be used to transform Schrödinger-Cat states embedded in the CV quantum cluster state to grid states (such as Gottesman-Kitaev-Preskill states) and enlarge the grid states. In certain embodiments, some of the methods may be used to generate and control non-Gaussian states in macronode cluster quantum states such as cluster states comprising two-mode macronodes.

Abstract: Provided herein are methods for introducing a foreign substance into a cell using high frequency electromagnetic energy. Provided are methods for delivery substances to both prokaryotic and to eukaryotic cells. Also provided are cells generated with the methods disclosed herein.

Abstract: The invention provides a pyrolysis reaction system, the system comprising: a pyrolysis chamber comprising a feed inlet, a gas inlet and a product outlet, wherein the pyrolysis chamber is configured i) to receive a pyrolysable organic feed and an inert gas via the feed inlet and gas inlet respectively, ii) to pyrolyse the organic feed at a pyrolysis temperature to produce a carbonaceous pyrolysis product and a pyrolysis gas, wherein the pyrolysis gas will combine with the inert gas to form a gas mixture having a pyrolysis chamber pressure in the pyrolysis chamber, and iii) to discharge the carbonaceous pyrolysis product via the product outlet; a gas reactor configured to react the pyrolysis gas by combustion and/or carbon deposition at a gas reaction temperature and a gas reactor pressure; and a first partition defining a boundary between the pyrolysis chamber and the gas reactor, the first partition comprising a plurality of first apertures to provide fluid communication between the pyrolysis chamber and the

Abstract: A compound according to Formula (I), or a pharmaceutically acceptable salt thereof: wherein R1 and R2 are each independently selected from optionally substituted C1-6-alkyl and optionally substituted aryl; R3, R4, R5, and R6 are each independently selected from the group consisting of H, halo, optionally substituted C1-6-alkyl, and optionally substituted C1-6 alkoxy; and R7 is a phosphorus containing moiety, wherein a phosphorus atom is bonded to Au.

Abstract: A method for evaluating Dry Eye Disease (“DED”) in a human or animal subject is provided. Thread thinning dynamics of a tear sample of the subject are determined using an acoustically-driven microfluidic extensional rheometry instrument. At least one physical parameter value of the tear sample is calculated based at least in part on the determined thread thinning dynamics. DED is evaluated based at least in part on the at least one calculated physical parameter value of the tear sample. A device for evaluating Dry Eye Disease (DED) in a human or animal subject is also provided. The device includes an acoustically-driven microfluidic extensional rheometry instrument and a processing device configured to evaluate DED based at least in part on the calculated at least one physical parameter value of the tear sample.

Abstract: A composition comprising reduced graphene oxide in the form of sheets that are interconnected to define pores between the sheets.

Abstract: A method for preparing an aqueous dispersion of metal oxide particles is disclosed. The method comprises the step of performing phase transfer of a plurality of metal oxide particles capped with hydrophobic ligands on a surface there of by contacting the metal oxide particles with a combination of tertiary amine and water to form a biphasic mixture, and agitating said biphasic mixture to produce an aqueous dispersion of metal oxide particles capped with hydrophobic ligands and tertiary amine ligands on the surface thereof.

Abstract: The present invention relates to formulations for the delivery of bioactive agents, and methods of preparing the formulations. More specifically, the present invention relates to a formulation for delivery of a bioactive agent comprising a hydrogel matrix that is the product of a reaction between hydroxypropyl methylcellulose (HPMC), acrylic acid (AAc) and N,N?-methylenebisacrylamide (MBA), and methods of preparing the formulations.

Abstract: A device, comprising: an electroacoustic transducer on a substrate; a power supply to supply electromagnetic wave energy to the electroacoustic transducer; and a source of a substance that is movable to the substrate; wherein the electroacoustic transducer and the substrate are configured to generate acoustic wave energy that is used to move the substance from the source to the substrate, and to manipulate the substance on the substrate.

Abstract: The invention provides a pyrolysis reaction system, the system comprising: a pyrolysis chamber comprising a feed inlet, a gas inlet and a product outlet, wherein the pyrolysis chamber is configured i) to receive a pyrolysable organic feed and an inert gas via the feed inlet and gas inlet respectively, ii) to pyrolyse the organic feed at a pyrolysis temperature to produce a carbonaceous pyrolysis product and a pyrolysis gas, wherein the pyrolysis gas will combine with the inert gas to form a gas mixture having a pyrolysis chamber pressure in the pyrolysis chamber, and iii) to discharge the carbonaceous pyrolysis product via the product outlet; a gas reactor configured to react the pyrolysis gas by combustion and/or carbon deposition at a gas reaction temperature and a gas reactor pressure; and a first partition defining a boundary between the pyrolysis chamber and the gas reactor, the first partition comprising a plurality of first apertures to provide fluid communication between the pyrolysis chamber and the

Abstract: A sensor for discriminating between wavelength regions in an electromagnetic spectrum is disclosed. The sensor comprising a substrate, a sensing element supported on a surface of the substrate, and at least one pair of terminal electrodes disposed on the substrate surface in mutually spaced apart and opposing relation, and in electrical contact with the sensing element, wherein the sensing element is responsive to electromagnetic radiation to yield a change in photocurrent measured between the terminal electrodes as a function of an intensity of the electromagnetic radiation impinging thereon, wherein a positive dependency on the intensity corresponds to a first wavelength region and a negative dependency on the intensity corresponds to a second wavelength region.

Abstract: The invention provides a method of sequential pyrolysis and carbon deposition to produce a composite carbonaceous product, the method comprising: a pyrolysis process step comprising pyrolyzing a pyrolyzable organic feed at a pyrolysis temperature in a first reaction zone in the presence of a non-oxidising gas to produce hot char and pyrolysis gas, wherein the pyrolysis gas and the non-oxidising gas combine to form a gas mixture; discharging the gas mixture from the first reaction zone to a combustion zone and combusting at least a portion of the pyrolysis gas therein, wherein heat produced by the combusting of the pyrolysis gas is transmitted from the combustion zone to the first reaction zone to provide at least a portion of the heat of pyrolysis; and a decomposition process step comprising contacting a hydrocarbon-rich organic gas with the hot char directly after its production in the pyrolysis process step, wherein the hydrocarbon-rich organic gas catalytically decomposes on the hot char at a decomposition

Abstract: An intracellular delivery device (1) including, a piezoelectric substrate (3) having a working surface (8), at least one interdigitated transducer (5) located on and in contact with the working surface (8), and a receptacle (11) located on the working surface for accommodating cells to be targeted for intracellular delivery therein, wherein an alternating signal applied to the interdigitated transducer generates acoustic wave energy through the piezoelectric substrate that can be transferred to the accommodated cells.

Abstract: The invention relates to multicore fiber imaging, such as used in endoscopy. Methods are described for processing images captured with such systems to achieve an improved depth of field image or extract 3D information concerning the images, without requiring the addition of additional optical components. One method for generating an image from light received by an imager via a multiplicity of waveguides includes receiving a digital image containing a plurality of pixels, the digital image including a plurality of regions within it wherein each of said regions corresponds to a waveguide core. Each region includes a plurality of pixels, and a first subset of pixels within each region is defined which at least partly correlates with light having been received at a corresponding core in a first spatial arrangement, the subset including less than all of the pixels within a region. A first image is generated from the first subset of pixels from said regions, combined to form an image over the whole waveguide array.

Abstract: This application discloses a device for detecting nicotine. The device includes a nicotine sensor comprising vanadium oxide (VO2), a processor and circuitry configured to detect a change in the electrical resistance of the nicotine sensor. The processor is configured to receive, from the circuitry, a signal representative of the detected change in the electrical resistance of the nicotine sensor and output data based on the detected change in electrical resistance of the nicotine sensor. A system and method for detecting nicotine are also disclosed.

Abstract: A multimodal PET (positron emission tomography)/MRI (magnetic resonance imaging) contrast agent, a process of synthesizing said PET/MRI contrast agent, and a pharmaceutical formulation comprising said PET/MRI contrast agent are disclosed. The PET/MRI contrast agent comprises a magnetic signal generating core, and a coating portion formed at least partially over a surface of said magnetic signal generating core, wherein the coating portion comprises a plurality of layers, including an inner layer having a functionalized surface, and an outer layer in the form of a radionuclide electrolessly plated layer formed on said functionalized surface.

Abstract: A method, including irradiating graphene oxide (GO) with a beam of light or radiation to form reduced graphene oxide (RGO) in a three-dimensional (3D) pattern, wherein the RGO is porous RGO with pores having sizes tuned by controlling the beam of light or radiation.

Abstract: The present disclosure is based on detecting CC chemokine receptor 4 (CCR4) expression on T effector cells to diagnostically or prophylactically predict subjects, in particular those with a gynaecological cancer who will respond to treatment with low dose cyclophosphamide.

Abstract: The invention provides a system for pyrolysis, comprising: (i) a gas producer comprising a gasification zone and a producer gas outlet, wherein the gas producer is configured to: oxidise at least one carbon-containing feed in the presence of an oxidising gas in the gasification zone to form a producer gas; and discharge the producer gas from the gasification zone via the producer gas outlet, wherein a residual oxygen content of the producer gas is substantially depleted or maintained below a maximum predetermined amount by controlling a ratio of oxygen fed to the gasification zone to the carbon-containing feed, (ii) a pyrolyzer comprising a pyrolysis zone and one or more pyrolyzer gas outlets, wherein the pyrolyzer is configured to: feed the producer gas discharged from the gasification zone to the pyrolysis zone; pyrolyze a pyrolyzable organic feed in the pyrolysis zone in the presence of the producer gas to produce a carbonaceous pyrolysis product and a gas mixture comprising combustible components comprisi

Abstract: A nebuliser for nebulising liquid droplets, including: a housing; at least one piezoelectric substrate (2) accommodated within the housing and having a transducer surface (2a) upon which is located at least one electroacoustic transducer (48) for generating acoustic wave energy within the at least one piezoelectric substrate (2), and an opposing non-transducer surface (2b); a liquid supply system for supplying a liquid to at least one of the transducer and non-transducer surfaces, the liquid supply system including a reservoir (3) for accommodating the liquid, and at least one relatively rigid supply conduit in contact with the at least one piezoelectric substrate (2) for supplying the liquid from the reservoir (3) to the at least one piezoelectric substrate (2); and a sensor for detecting a volume of liquid on the at least one piezoelectric substrate (2).