Abstract: A ceramic biomolecule imaging chip includes a ceramic body having a planar imaging surface. The planar imaging surface is highly polished within tolerances of plus or minus 1 microinch. This ceramic chip is compatible with fluorescence laser scanning devices. It is preferred that the ceramic body be 99.6% alumina oxide in order to also be compatible with non-fluorescent detection systems.

Abstract: A panel chip for supporting biological samples for observation with an imaging microscope. The glass panel defines a top flat surface, a bottom bearing surface, and at least a few channels extending generally parallel to each other from top to bottom surfaces. Each of the channels defines a top access mouth for ingress of biological. The channels are arranged in subgroups made of a number of unit cells. Instead of being cylindroid, these channels may form cross sectional rectangular or arcuate channels, or cross sectionally water droplet like channels. Each channel has such an inner diameter as to accommodate flow through viscosity of a biological sample containing fluid. The porous substrate that is created by slot channel can provide the maximum binding surface area per unit cell or pixel, as compared to cylindrical pores, thus achieving higher sensitivity and better imaging. Also, this panel chip is capable of being used as direct in situ synthesizing of molecules and drugs.

Abstract: A panel chip for supporting biological samples for observation with a microscope. The glass panel defines a top flat surface, a bottom bearing surface, and at least a few channels extending generally parallel to each other from top to bottom surfaces. Each of the channels defines a top access mouth for ingress of biological samples, wherein each channel is obliquely inclined so as to make a significant acute angle relative to an axis perpendicular to said top flat surface, in order to facilitate the guidance of maximum light into the channel due to zero loss of reflection and to produce the maximum number of total internal reflection and to guide the maximum light out of the microchannel in such a manner that produces no artifact halo for maximum detection and sensitivity. Each channel has such an inner diameter as to accommodate flow through viscosity of a biological sample containing fluid.