Patents Assigned to Royer Biomedical, Inc.
  • Patent number: 8664280
    Abstract: A kit for forming a bioerodible composition is provided with a first aliquot portion of a reaction mixture having an aldehydic polymer solution, and a second aliquot portion of a reaction mixture having solids which include a cross-linking hydrazide. When mixed, the first and second aliquot portions of the reaction mixture react at a pH of 4 to 6 to form a solidified bioerodible composition within about 1 to about 10 minutes, to form a hydrazide cross-linked aldehydic polymer matrix. The bioerodable composition may be usefully employed to seal and/or treat wounds (e.g., a surgical incision).
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: March 4, 2014
    Assignee: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer
  • Patent number: 8435565
    Abstract: A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for the controlled release of the bioactive agent from the composition. The composition may be administered to a body site in need of the same by providing a first aliquot portion of a reaction mixture which includes the reactants and a bioactive agent. A kit which includes a double syringe respectively containing the first and second aliquot portions of the reaction mixture may be provided so that the same may be mixed just prior to use.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: May 7, 2013
    Assignee: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer
  • Patent number: 8039021
    Abstract: A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for controlled release of the bioactive agent from the composition.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: October 18, 2011
    Assignee: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer
  • Publication number: 20050266076
    Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of anti-cancer agents. Advantageously, the inorganic used is calcium sulfate. The invention also includes novel methods of treating cancer.
    Type: Application
    Filed: June 17, 2003
    Publication date: December 1, 2005
    Applicant: Royer Biomedical, Inc.
    Inventor: Garfield Royer
  • Patent number: 6869976
    Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: March 22, 2005
    Assignee: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer
  • Publication number: 20040208934
    Abstract: The production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals are disclosed. Advantageously, the inorganic used is calcium sulfate.
    Type: Application
    Filed: May 5, 2004
    Publication date: October 21, 2004
    Applicant: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer
  • Patent number: 6630486
    Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: October 7, 2003
    Assignee: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer
  • Publication number: 20030170307
    Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.
    Type: Application
    Filed: February 13, 2003
    Publication date: September 11, 2003
    Applicant: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer
  • Patent number: 6497901
    Abstract: This invention relates generally to the production and use of inorganic-conditioning agent complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate and the conditioning agent is calcium stearate.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: December 24, 2002
    Assignee: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer
  • Patent number: 6391336
    Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. The inorganic compound used is advantageously calcium sulfate-hemihydrate. The invention includes a composition for the controlled release of an active agent comprising: a) a hydrated or crystallized inorganic compound, and b) a matrix polymer which slows the release of the active agent, wherein the composition is a solid matrix due to the hydration or crystallization of the inorganic compound. Further included is a composition for the controlled release of an active agent comprising: a) a hydrated or crystallized inorganic compound, and b) a complexing agent which forms a salt or conjugate with the active agent, wherein the composition is a solid matrix due to the hydration or crystallization of the inorganic compound.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: May 21, 2002
    Assignee: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer