Patents Assigned to Royer Biomedical, Inc.
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Patent number: 9089609Abstract: Bioactive agents are delivered to a body site in need of the same by providing a first aliquot portion of a reaction mixture which includes an aldehydic polymer solution, and a second aliquot portion of a reaction which includes a cross-linking hydrazide and a bioactive agent. The first and second aliquot portions may be mixed (e.g., by expelling such portions from respective syringe barrels) to form the reaction mixture thereof. The thus formed reaction mixture may then be installed at the body site whereby the reaction mixture is allowed to solidify in situ within about 1 to 10 minutes into a reaction product comprised of a hydrazide cross-linked oxidized aldehydic polymer matrix with the bioactive agent entrapped therein.Type: GrantFiled: February 26, 2014Date of Patent: July 28, 2015Assignee: ROYER BIOMEDICAL, INC.Inventor: Garfield P. Royer
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Publication number: 20140248298Abstract: Bioactive agents are delivered to a body site in need of the same by providing a first aliquot portion of a reaction mixture which includes an aldehydic polymer solution, and a second aliquot portion of a reaction which includes a cross-linking hydrazide and a bioactive agent. The first and second aliquot portions may be mixed (e.g., by expelling such portions from respective syringe barrels) to form the reaction mixture thereof. The thus formed reaction mixture may then be installed at the body site whereby the reaction mixture is allowed to solidify in situ within about 1 to 10 minutes into a reaction product comprised of a hydrazide cross-linked oxidized aldehydic polymer matrix with the bioactive agent entrapped therein.Type: ApplicationFiled: February 26, 2014Publication date: September 4, 2014Applicant: ROYER BIOMEDICAL, INC.Inventor: Garfield P. ROYER
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Patent number: 8664280Abstract: A kit for forming a bioerodible composition is provided with a first aliquot portion of a reaction mixture having an aldehydic polymer solution, and a second aliquot portion of a reaction mixture having solids which include a cross-linking hydrazide. When mixed, the first and second aliquot portions of the reaction mixture react at a pH of 4 to 6 to form a solidified bioerodible composition within about 1 to about 10 minutes, to form a hydrazide cross-linked aldehydic polymer matrix. The bioerodable composition may be usefully employed to seal and/or treat wounds (e.g., a surgical incision).Type: GrantFiled: April 22, 2013Date of Patent: March 4, 2014Assignee: Royer Biomedical, Inc.Inventor: Garfield P. Royer
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Publication number: 20130245549Abstract: Bioactive agents are embedded in a cross-linked dextran and coated with a bioresorbable polymer. When implanted in a mammal, the coated cross-linked dextran composition produces controlled release of the embedded bioactive agent.Type: ApplicationFiled: September 12, 2012Publication date: September 19, 2013Applicant: ROYER BIOMEDICAL, INC.Inventors: Garfield P. ROYER, Tatiana Bizikova
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Publication number: 20130237614Abstract: A kit for forming a bioerodible composition is provided with a first aliquot portion of a reaction mixture having an aldehydic polymer solution, and a second aliquot portion of a reaction mixture having solids which include a cross-linking hydrazide. When mixed, the first and second aliquot portions of the reaction mixture react at a pH of 4 to 6 to form a solidified bioerodible composition within about 1 to about 10 minutes, to form a hydrazide cross-linked aldehydic polymer matrix. The bioerodable composition may be usefully employed to seal and/or treat wounds (e.g., a surgical incision).Type: ApplicationFiled: April 22, 2013Publication date: September 12, 2013Applicant: ROYER BIOMEDICAL, INC.Inventor: Garfield P. ROYER
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Patent number: 8435565Abstract: A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for the controlled release of the bioactive agent from the composition. The composition may be administered to a body site in need of the same by providing a first aliquot portion of a reaction mixture which includes the reactants and a bioactive agent. A kit which includes a double syringe respectively containing the first and second aliquot portions of the reaction mixture may be provided so that the same may be mixed just prior to use.Type: GrantFiled: September 8, 2011Date of Patent: May 7, 2013Assignee: Royer Biomedical, Inc.Inventor: Garfield P. Royer
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Publication number: 20110318416Abstract: A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for the controlled release of the bioactive agent from the composition.Type: ApplicationFiled: September 8, 2011Publication date: December 29, 2011Applicant: ROYER BIOMEDICAL, INC.Inventor: Garfield P. ROYER
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Patent number: 8039021Abstract: A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for controlled release of the bioactive agent from the composition.Type: GrantFiled: November 9, 2007Date of Patent: October 18, 2011Assignee: Royer Biomedical, Inc.Inventor: Garfield P. Royer
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Publication number: 20070110804Abstract: This invention relates to polymeric complexes of drugs to be employed as (or in) sustained release-formulations comprising a cationic active agent, and a polyanionic water soluble complexing polymer of sufficient molecular weight that it forms a gel when mixed with said active agent. The invention also relates to the manufacture of such sustained release compositions and their many uses. Also included is a molded prosthesis comprising a prosthesis including a sustained release composition comprising a cationic anti-infective and a complexing polymer.Type: ApplicationFiled: June 18, 2004Publication date: May 17, 2007Applicant: ROYER BIOMEDICAL, INC.Inventor: Garfield Royer
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Publication number: 20050266076Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of anti-cancer agents. Advantageously, the inorganic used is calcium sulfate. The invention also includes novel methods of treating cancer.Type: ApplicationFiled: June 17, 2003Publication date: December 1, 2005Applicant: Royer Biomedical, Inc.Inventor: Garfield Royer
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Patent number: 6869976Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.Type: GrantFiled: February 13, 2003Date of Patent: March 22, 2005Assignee: Royer Biomedical, Inc.Inventor: Garfield P. Royer
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Publication number: 20040208934Abstract: The production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals are disclosed. Advantageously, the inorganic used is calcium sulfate.Type: ApplicationFiled: May 5, 2004Publication date: October 21, 2004Applicant: Royer Biomedical, Inc.Inventor: Garfield P. Royer
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Patent number: 6630486Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.Type: GrantFiled: March 21, 2000Date of Patent: October 7, 2003Assignee: Royer Biomedical, Inc.Inventor: Garfield P. Royer
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Publication number: 20030170307Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.Type: ApplicationFiled: February 13, 2003Publication date: September 11, 2003Applicant: Royer Biomedical, Inc.Inventor: Garfield P. Royer
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Patent number: 6497901Abstract: This invention relates generally to the production and use of inorganic-conditioning agent complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate and the conditioning agent is calcium stearate.Type: GrantFiled: November 2, 2000Date of Patent: December 24, 2002Assignee: Royer Biomedical, Inc.Inventor: Garfield P. Royer
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Patent number: 6391336Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. The inorganic compound used is advantageously calcium sulfate-hemihydrate. The invention includes a composition for the controlled release of an active agent comprising: a) a hydrated or crystallized inorganic compound, and b) a matrix polymer which slows the release of the active agent, wherein the composition is a solid matrix due to the hydration or crystallization of the inorganic compound. Further included is a composition for the controlled release of an active agent comprising: a) a hydrated or crystallized inorganic compound, and b) a complexing agent which forms a salt or conjugate with the active agent, wherein the composition is a solid matrix due to the hydration or crystallization of the inorganic compound.Type: GrantFiled: September 22, 1997Date of Patent: May 21, 2002Assignee: Royer Biomedical, Inc.Inventor: Garfield P. Royer