Patents Assigned to RSR Limited
-
Patent number: 11732026Abstract: A mutant thyroid stimulating hormone receptor (TSHR) or fragment thereof comprises one or more mutations, wherein the mutant TSHR has increased thermostability with respect to the equivalent wild type TSHR or fragment. The one or more mutation is preferably within the extracellular leucine-rich repeat domain (LRD) of the TSHR, or within residues 22 to 260 (TSHR260) of the TSHR, or may be in the transmembrane domain (TMD), A mutant TSHR or fragment thereof of the invention preferably consists of, or consists essentially of, the subdomain TSHR260 of the TSHR receptor. A mutant TSHR or fragment thereof according to the invention has a greater thermostability than the equivalent wild type TSHR or fragment as determined by its half-life at a given temperature, and can be purified whilst retaining activity. A mutant TSHR or fragment thereof according to the invention may also be deglycosylated whilst retaining activity.Type: GrantFiled: June 11, 2015Date of Patent: August 22, 2023Assignee: RSR LimitedInventors: Bernard Rees Smith, Jadwiga Furmaniak, Jane Sanders, Jennifer Miller-Gallacher
-
Patent number: 9435797Abstract: A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogs, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising `antigenic molecule of fist source!-`analyte auto antibody!-`antigenic molecule of second source! The antigenic molecule of first source is immobilized to a solid phase, the second is labeled.Type: GrantFiled: March 5, 2012Date of Patent: September 6, 2016Assignee: RSR LimitedInventors: Bernard Rees Smith, Jadwiga Furmaniak, Michael Powell
-
Patent number: 9046519Abstract: A mutated TSHR preparation which includes at least one point mutation characterized in that at least amino acid Arg at a position corresponding to amino acid 255 of a full length human TSHR has been mutated to a different amino acid residue in said mutated TSHR preparation, whereby said mutated TSHR preparation differentially interacts with patient serum stimulating TSHR autoantibodies, patient serum blocking TSHR autoantibodies and TSH, in that (i) the stimulatory effect of patient serum stimulating TSHR autoantibodies interacting with the mutated TSHR preparation is substantially reduced or essentially abolished, when compared to the stimulatory effect of the patient serum stimulating TSHR autoantibodies interacting with a reference TSHR preparation which has an amino acid sequence corresponding to that of said mutated TSHR preparation with the exception that said mutation of Arg at a position corresponding to amino acid 255 of a full length human TSHR is not present in said reference TSHR preparation, (ii)Type: GrantFiled: August 3, 2005Date of Patent: June 2, 2015Assignee: RSR LimitedInventors: Bernard Rees Smith, Jadwiga Furmaniak, Jane Sanders
-
Patent number: 8900823Abstract: A binding partner for the TSH receptor, which binding partner comprises, or is derived from, a human monoclonal or recombinant antibody, or one or more fragments thereof, reactive with the TSH receptor, uses thereof, methods of diagnosis and therapy employing the same, and anti-idiotypic antibodies thereto.Type: GrantFiled: December 29, 2011Date of Patent: December 2, 2014Assignee: RSR LimitedInventors: Jane Sanders, Jadwiga Furmaniak, Bernard Rees Smith
-
Patent number: 8840891Abstract: The invention provides an isolated antibody for the TSHR which is an antagonist of TSH. The invention also relates to methods of using antibodies of the invention.Type: GrantFiled: February 14, 2008Date of Patent: September 23, 2014Assignee: RSR LimitedInventors: Bernard Rees Smith, Jadwiga Furmaniak, Jane Sanders
-
Patent number: 8753637Abstract: A binding partner for the TSH receptor, which binding partner comprises, or is derived from, a human monoclonal or recombinant antibody, or one or more fragments thereof, reactive with the TSH receptor, uses thereof, methods of diagnosis and therapy employing the same, and anti-idiotypic antibodies thereto.Type: GrantFiled: December 28, 2011Date of Patent: June 17, 2014Assignee: RSR LimitedInventors: Jane Sanders, Jadwiga Furmaniak, Bernard Rees Smith
-
Patent number: 8309693Abstract: The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto.Type: GrantFiled: December 12, 2008Date of Patent: November 13, 2012Assignee: RSR LimitedInventors: Bernard Rees Smith, Jadwiga Furmaniak, Jane Fina Sanders
-
Patent number: 8298771Abstract: The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto.Type: GrantFiled: December 12, 2008Date of Patent: October 30, 2012Assignee: RSR LimitedInventors: Bernard Rees Smith, Jadwiga Furmaniak, Jane Fina Sanders
-
Patent number: 8298769Abstract: The present invention is concerned with epitope regions of thyrotrophin (TSH) receptor, uses thereof and antibodies thereto.Type: GrantFiled: August 21, 2002Date of Patent: October 30, 2012Assignee: RSR LimitedInventors: Bernard Rees Smith, Jadwiga Furmaniak, Jane Fina Sanders
-
Publication number: 20120225955Abstract: A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising `antigenic molecule of fist source!-`analyte auto antibody!-`antigenic molecule of second source! The antigenic molecule of first source is immobilised to a solid phase, the second is labeled.Type: ApplicationFiled: March 5, 2012Publication date: September 6, 2012Applicant: RSR LimitedInventors: Bernard Rees SMITH, Jadwiga Furmaniak, Michael Powell
-
Patent number: 8129132Abstract: A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method.Type: GrantFiled: November 26, 2002Date of Patent: March 6, 2012Assignee: RSR LimitedInventors: Bernard Rees Smith, Jadwiga Furmaniak, Michael Powell
-
Patent number: 8110664Abstract: A binding partner for the TSH receptor, which binding partner comprises, or is derived from, a human monoclonal or recombinant antibody, or one or more fragments thereof, reactive with the TSH receptor, uses thereof, methods of diagnosis and therapy employing the same, and anti-idiotypic antibodies thereto.Type: GrantFiled: November 28, 2003Date of Patent: February 7, 2012Assignee: RSR LimitedInventors: Jane Sanders, Jadwiga Furmaniak, Bernard Rees Smith
-
Patent number: 8097699Abstract: This invention relates to a crystallizable composition comprising a TSHR polypeptide, to crystals comparing a TSHR polypeptide and to TSHR-related applications.Type: GrantFiled: August 29, 2007Date of Patent: January 17, 2012Assignee: RSR LimitedInventors: Jane Sanders, Jadwiga Furmaniak, Bernard Rees Smith
-
Publication number: 20090203036Abstract: The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto.Type: ApplicationFiled: December 12, 2008Publication date: August 13, 2009Applicant: RSR LimitedInventors: Bernard Rees SMITH, Jadwiga Furmaniak, Jane Fina Sanders
-
Publication number: 20090202438Abstract: The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto.Type: ApplicationFiled: December 12, 2008Publication date: August 13, 2009Applicant: RSR LimitedInventors: Bernard Rees SMITH, Jadwiga Furmaniak, Jane Fina Sanders
-
Patent number: 7001775Abstract: A method and kit for screening a sample of body fluid for at least one autoantibody to at least one antigen. A source of at least one antigen to the autoantibody is provided. A substrate having immobilized thereto at least one antibody to the antigen is also provided. The antigen source is contacted with the sample of body fluid, so as to obtain a mixture wherein the antigen is allowed to substantially bind with the autoantibody, when the latter is present in the sample of body fluid. The mixture is allowed to flow relative to the substrate so as to allow the mixture to contact the antibody immobilized to the substrate. Labeling means are provided to permit monitoring of binding of the autoanitbody and the antigen present in the mixture, so as to provide an indication of the presence of the autoanitbody in the sample of body fluid.Type: GrantFiled: October 27, 1999Date of Patent: February 21, 2006Assignee: RSR LimitedInventors: Peter John Burne, Bernard Rees Smith
-
Publication number: 20050118638Abstract: The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto.Type: ApplicationFiled: August 21, 2002Publication date: June 2, 2005Applicant: RSR LimitedInventors: Bernard Smith, Jadwiga Furmaniak, Jane Sanders
-
Patent number: 6844162Abstract: A method and kit for monitoring autoantibodies to thyroid stimulating hormone (TSH) receptor in a sample of body fluid, which employs the steps of: (i) incubating TSH receptor with a sample of body fluid; (ii) reacting the incubated sample of body fluid with at least one binding agent which is capable of binding to the TSH receptor in competitive reaction with TSH receptor autoantibodies (TRAb), or in a case where TSH receptor is complexed to labelled antibody, reacting the sample of body fluid with at least one binding agent which can bind to TRAb in such a way as not substantially to interfere with binding of the TRAb to the TSH receptor; and (iii) detecting bound TRAb in the reacted incubated sample of body fluid.Type: GrantFiled: January 31, 2000Date of Patent: January 18, 2005Assignee: RSR LimitedInventors: Bernard Rees Smith, Jane Sanders, Jadwiga Furmaniak
-
Patent number: 6455267Abstract: Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.Type: GrantFiled: June 7, 1995Date of Patent: September 24, 2002Assignees: Diamyd Medical AB, RSR Limited, Perkin Elmer Life SciencesInventors: Allan J. Tobin, Mark G. Erlander, Daniel L. Kaufman
-
Patent number: 6342394Abstract: Diagnosis of overt, subclinical or potential autoimmune adrenal disease, by contacting a sample of body fluid with: (i) at least one epitope region of 21-hydroxylase which epitope region is essential for binding monoclonal or polyclonal antibodies to 21-hydroxylase and/or autoantibodies to 21-hydroxylase; and (ii) monoclonal or polycolonal antibodies to 21-hydroxylase. The degree of binding of the autoantibodies present in the sample to the relevant epitope region is monitored.Type: GrantFiled: November 8, 1999Date of Patent: January 29, 2002Assignee: RSR LimitedInventors: Bernard Rees Smith, Jadwiga Furmaniak