Abstract: According to one aspect there is provided An isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.
Type:
Grant
Filed:
July 2, 2015
Date of Patent:
October 1, 2019
Assignee:
RSR Ltd.
Inventors:
Bernard Rees-Smith, Jane Sanders, Jadwiga Furmaniak
Abstract: According to one aspect there is provided an isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity, wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.
Type:
Grant
Filed:
December 23, 2009
Date of Patent:
July 7, 2015
Assignee:
RSR Ltd.
Inventors:
Bernard Rees-Smith, Jane Sanders, Jadwiga Furmaniak