Patents Assigned to RTI Biologics, Inc.
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Publication number: 20150265395Abstract: Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of harvesting grafts that has improved efficiency and increases the quantity of extracted tissue and minimizes time required by surgeon for implantation.Type: ApplicationFiled: March 26, 2015Publication date: September 24, 2015Applicant: RTI Biologics, Inc.Inventors: Kevin C. Carter, Michael Esch, Paul LaRochelle, Jim Gross
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Patent number: 8470038Abstract: The present invention relates to a bone-tendon-bone graft and components. Embodiments of the present invention comprise an intermediate bone block that is used to adjustably secure soft tissue (e.g., tendon) in a patient. Embodiments of intermediate bone blocks of the present invention are used singly or in combination with one or more bone blocks to form a bone block assembly for securing soft tissue. The present invention further relates to an assembled bone-tendon-bone graft for implantation in humans comprising the intermediate bone block and a length of soft tissue. A bone-tendon-bone graft comprises a length of soft tissue extending from a first assembled bone block to a second bone block and then doubles back to said first assembled bone block. Depending upon the embodiment, the second bone block fixedly or slideably attaches to the length of soft tissue and facilitates it doubling back to the first assembled bone block.Type: GrantFiled: December 19, 2005Date of Patent: June 25, 2013Assignee: RTI Biologics, Inc.Inventors: John R. Bianchi, Zhukauskas A. Arunas, Todd E. Goede, Lauren M. Brown, Guy B. Grover, Wesley I. Lewis, Joe Kutsavage
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Publication number: 20130149356Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.Type: ApplicationFiled: February 7, 2013Publication date: June 13, 2013Applicant: RTI BIOLOGICS, INC.Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell
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Patent number: 8394141Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.Type: GrantFiled: September 9, 2010Date of Patent: March 12, 2013Assignee: RTI Biologics, Inc.Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell
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Patent number: 8291572Abstract: An implant composed substantially of cortical bone is provided for use in cervical Smith-Robinson vertebral fusion procedures. The implant is derived from allograft or autograft cortical bone sources, is machined to form a symmetrically or asymmetrically shaped (e.g. a substantially āDā-shaped) implant having a canal running therethrough according to methods of this invention, and inserted into the space between adjacent cervical vertebrae to provide support and induce fusion of the adjacent vertebrae. Osteogenic, osteoinductive or osteoconductive materials may be packed into the canal of the implant to expedite vertebral fusion and to allow autologous bony ingrowth.Type: GrantFiled: January 19, 2010Date of Patent: October 23, 2012Assignee: RTI Biologics, Inc.Inventors: Jamie M. Grooms, Kevin C. Carter, Diane Carter, legal representative, Tom Sander, David H. Dulebohn
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Publication number: 20120245687Abstract: Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a a method of harvesting grafts that has improved efficiency and increases the quantity of extracted tissue and minimizes time required by surgeon for implantation.Type: ApplicationFiled: March 27, 2012Publication date: September 27, 2012Applicant: RTI BIOLOGICS, INC.Inventors: Kevin C. Carter, Michael Esch, Paul LaRochelle, Jim Gross
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Patent number: 8167943Abstract: Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of harvesting grafts that has improved efficiency and increases the quantity of extracted tissue and minimizes time required by surgeon for implantation.Type: GrantFiled: May 14, 2004Date of Patent: May 1, 2012Assignee: RTI Biologics, Inc.Inventors: Kevin C. Carter, Michael Esch, Paul LaRochelle, Jim Gross
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Patent number: 8142991Abstract: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: GrantFiled: February 19, 2009Date of Patent: March 27, 2012Assignee: RTI Biologics, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke
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Patent number: 8110001Abstract: Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a porcine bone tendon bone graft for use in orthopedic procedures. Also disclosed are multiple embodiments of assembled bone tendon bone blocks for use in orthopedic surgeries. Additionally, a method of harvesting grafts that has improved efficiency, increases the quantity of extracted tissue and minimizes time required by surgeon for implantation is disclosed.Type: GrantFiled: September 21, 2009Date of Patent: February 7, 2012Assignee: RTI Biologics, Inc.Inventors: Kevin C. Carter, Diane Carter, legal representative, Richard Ferguson
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Patent number: 8105379Abstract: Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a porcine bone tendon bone graft for use in orthopedic procedures. Additionally, Also a method of harvesting grafts that has improved efficiency, increases the quantity of extracted tissue and minimizes time required by surgeon for implantation is disclosed.Type: GrantFiled: April 27, 2007Date of Patent: January 31, 2012Assignee: RTI Biologics, Inc.Inventors: Kevin C. Carter, Diane Carter, legal representative, Michael Esch, Paul LaRochelle, Gina Scurti
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Patent number: 8092537Abstract: Instrument and implants are disclosed which provide for insertion of an implant into an intervertebral disc space from multiple approaches to the spine. Specifically, as a preferred aspect of the invention the implant includes a tapered portion and the implant may be inserted from multiple approaches to the spine with the orientation and taper properly oriented in the disc space regardless of the approach.Type: GrantFiled: December 1, 2009Date of Patent: January 10, 2012Assignees: Warsaw Orthopedic, Inc., RTI Biologics, Inc.Inventors: Thomas V. McGahan, Steven D. DeRidder, Dayna Buskirk, Eric C. Lange
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Patent number: 8007533Abstract: The present technology is related to the field of bone-tendon-bone implants, grafts, and components thereof, for implantation in mammals, particularly for implantation in humans. More particularly, the present technology relates to assembled implants that comprise a length of tendon and at least two bone components or intermediate bone blocks that are assembled to form a bone-tendon-bone implant, and methods of making such implants. In some embodiments, implants of the present technology provide a first grip on the tendon prior to implantation and a second grip during or after implantation. In some embodiments, bone block assemblies or intermediate bone blocks of the present technology have a first geometric configuration prior to implantation and a second geometric configuration during or after implantation.Type: GrantFiled: February 12, 2007Date of Patent: August 30, 2011Assignee: RTI Biologics, Inc.Inventors: Arunas A. Zhukauskas, Todd E. Goede, Eric J. Schmitt, Lauren M. Brown, Guy B. Grover, Predrag Bursac, Ben R. Sanders
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Patent number: 7883541Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.Type: GrantFiled: December 3, 2007Date of Patent: February 8, 2011Assignee: RTI Biologics, Inc.Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
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Patent number: 7824702Abstract: Disclosed herein is an efficient and cost-effective system for reconstituting bone pastes comprising a first syringe containing a reconstitution fluid and second syringe containing paste components, wherein said first and second syringes are communicatingly interconnectable. Also disclosed are novel methods for producing and storing bone pastes. Alternatively, a mixing syringe is disclosed, which is useful for reconstituting a paste, inter alia, comprising a flexible midportion, whereby repeated compression of the flexible midportion results in mixing the contents of the syringe.Type: GrantFiled: February 5, 2008Date of Patent: November 2, 2010Assignee: RTI Biologics, Inc.Inventors: John F. Wironen, Penelope Kao, Andy Bernhardt
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Patent number: 7776089Abstract: The present invention has multiple aspects. In its simplest aspect, the present invention is directed to an intermediate bone block comprising a machined segment of cortical bone, cancellous bone or both, the intermediate having a face comprising one to ten compression surfaces and one to ten cavities, the compression surfaces suitable for compressing soft tissue, the cavities for receiving and holding overflow soft tissue. The cavities are preferably channels, and more preferably channels having an omega cross-sectional profile. The invention is also directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particularly preferred graft is a bone-tendon-bone graft.Type: GrantFiled: March 4, 2005Date of Patent: August 17, 2010Assignee: RTI Biologics, Inc.Inventors: John R. Bianchi, Wesley I. Lewis, Joe Kutsavage, Dan Urbaniak, Angela Carr, Glenn C. Klein, Ben R. Sanders
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Patent number: 7763071Abstract: The present invention has multiple aspects. In its simplest aspect, the present invention is directed to an intermediate bone block comprising a machined segment of cortical bone, cancellous bone or both, the intermediate having a face comprising one to ten compression surfaces and one to ten cavities, the compression surfaces suitable for compressing soft tissue, the cavities for receiving and holding overflow soft tissue. The cavities are preferably channels, and more preferably channels having an omega cross-sectional profile. The invention is also directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particularly preferred graft is a bone-tendon-bone graft.Type: GrantFiled: March 4, 2005Date of Patent: July 27, 2010Assignee: RTI Biologics, Inc.Inventors: John R. Bianchi, Wesley I. Lewis
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Patent number: 7763072Abstract: The present invention is directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particularly preferred graft is a bone-tendon-bone graft. In its simplest aspect, the present invention is directed to an intermediate bone block comprising a machined segment of cortical bone, cancellous bone or both.Type: GrantFiled: March 4, 2005Date of Patent: July 27, 2010Assignee: RTI Biologics, Inc.Inventors: John R Bianchi, Wesley I Lewis
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Patent number: D625822Type: GrantFiled: November 23, 2009Date of Patent: October 19, 2010Assignee: RTI Biologics, Inc.Inventors: Wesley I. Lewis, John R. Bianchi, Joe Kutsavage, Arunas A. Zhukauskas
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Patent number: D630329Type: GrantFiled: May 26, 2010Date of Patent: January 4, 2011Assignee: RTI Biologics, Inc.Inventors: Todd E. Goede, Arunas A. Zhukauskas, Eric Schmitt, Guy B. Grover
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Patent number: D630748Type: GrantFiled: February 12, 2008Date of Patent: January 11, 2011Assignee: RTI Biologics, Inc.Inventors: Todd E. Goede, Arunas A. Zhukauskas, Eric Schmitt, Guy B. Grover