Patents Assigned to RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE
  • NRAS related cancer therapy
    Patent number: 10781471
    Abstract: The present invention encompasses the recognition that identification of alternative means to block RAS oncogenic signaling may be required for developing novel cancer therapies. Among other things, the present invention encompasses the recognition that targeting RAS palmitoylation can achieve effective therapy for RAS-related cancers. Furthermore, the present invention encompasses the recognition that reduction of ZDHHC9 level and/or activity can significantly reduce palmitoylation level of Ras protein. Among other things, the present invention encompasses the recognition that identification of agents that modulate expression and/or activity of ZDHHC9 can reduce palmitoylation level of Ras protein. In some embodiments, the present invention provides methods of treating a subject suffering from cancer by administering ZDHHC9 inhibition therapy.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 22, 2020
    Assignees: Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Brandeis University
    Inventor: Ruibao Ren
  • Preparation and use of novel protein kinase inhibitors
    Patent number: 10364247
    Abstract: The invention provides novel compounds and methods of using such compounds to treat or prevent cancer.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: July 30, 2019
    Assignees: Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Xiamen University, Brandeis University
    Inventors: Ruibao Ren, Xianming Deng, Ping Liu, Bo Jiao, Wei Huang
  • Uses of in treatment or prevention of obesity and obesity-related diseases
    Patent number: 10350248
    Abstract: Provided are uses of Bacteroides in preparation of a medicament. The medicament is for use in treatment or prevention of obesity and obesity-related diseases. Also provided are a pharmaceutical composition, a medicament, a food product, and an animal feed that comprise Bacteroides, uses thereof in treatment or prevention of obesity and obesity-related diseases, and a method for treatment or prevention of obesity and obesity-related diseases.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: July 16, 2019
    Assignee: RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Guang Ning, Jie Hong, Weiqing Wang, Ruixin Liu, Jiqiu Wang