Abstract: A pharmaceutical with an enhanced pharmaceutical profile comprises a mucolytic and an antibiotic in which the mucolytic is present in an amount of greater than one molar equivalent of the antibiotic. The antibiotic may be selected from Erythromycin, Roxithromycin, Clarithromycin, Azithromycin, Dirithromycin; and pharmaceutically acceptable salts or esters thereof. The mucolytic is a mucolytically active thiol, especially N-acetylcysteine, mercaptoethanesulfonic acid, tiopronin or methylcysteine. The adducts can be isolated via a simple and efficient process.
Type:
Grant
Filed:
April 19, 2001
Date of Patent:
July 29, 2003
Assignee:
Russinsky Limited
Inventors:
Helmut Schickaneder, Aggelos Nikolopoulos, Gesine Hermann
Abstract: Cis-Tramadol hydrochloride is prepared by forming a Mannich hydrochloride, liberating the Mannich base, reacting the Mannich base with a Grignard reagent to form a base hydrate of cis-Tramadol which is used to form pure cis-Tramadol hydrochloride. Also claimed is the base hydrate of cis-Tramadol per se and its use as a medicament.
Type:
Grant
Filed:
January 14, 2000
Date of Patent:
October 22, 2002
Assignee:
Russinsky Limited
Inventors:
Helmut Schickaneder, Aggelos Nikolopoulos