Patents Assigned to Rutgers, The State University
  • Semiconductor devices including polar insulation layer capped by non-polar insulation layer
    Patent number: 9362367
    Abstract: Illustrative embodiments of semiconductor devices including a polar insulation layer capped by a non-polar insulation layer, and methods of fabrication of such semiconductor devices, are disclosed. In at least one illustrative embodiment, a semiconductor device may comprise a semiconductor substrate, a polar insulation layer disposed on the semiconductor substrate and comprising a Group V element configured to increase a carrier mobility in at least a portion of the semiconductor substrate, and a non-polar insulation layer disposed above the polar insulation layer.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: June 7, 2016
    Assignees: Auburn University, Rutgers, The State University of New Jersey
    Inventors: John R. Williams, Ayayi C. Ahyi, Tamara F Isaacs-Smith, Yogesh K. Sharma, Leonard C. Feldman
  • PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS DIAGNOSTIC REAGENTS AND VACCINES
    Publication number: 20160153986
    Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
    Type: Application
    Filed: January 6, 2016
    Publication date: June 2, 2016
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Maria Laura Gennaro
  • INSULIN-MIMETICS AS THERAPEUTIC ADJUNCTS FOR BONE REGENERATION
    Publication number: 20160151416
    Abstract: Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic, agents or compositions thereof to patients in need of such treatment are also disclosed.
    Type: Application
    Filed: January 29, 2016
    Publication date: June 2, 2016
    Applicants: Rutgers, The State University of New Jersey, Rutgers, The State University of New Jersey
    Inventors: Sheldon S. Lin, David N. Paglia, James P. O'Connor, Joseph Benevenia, Aaron Wey, Sangeeta Subramanian, John Koerner, Paul Chirichella, Michael J. Vives
  • Cranberry variety named 'CNJ99-9-96'
    Publication number: 20160150694
    Abstract: A new cranberry variety distinguished by mid-season ripening, round to ovate fruit, high productivity, and moderate fruit anthocyanin development, as compared to the currently cultivated commercial varieties.
    Type: Application
    Filed: November 24, 2014
    Publication date: May 26, 2016
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Nicholi Vorsa, Jennifer Johnson-Cicalese
  • CRANBERRY VARIETY NAMED 'CNJ99-52-15'
    Publication number: 20160150693
    Abstract: A new cranberry variety distinguished by early mid-season ripening period, precocious cropping, high productivity, and moderate-to-high fruit anthocyanin development, as compared to the currently cultivated commercial varieties.
    Type: Application
    Filed: November 24, 2014
    Publication date: May 26, 2016
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Nicholi Vorsa, Jennifer Johnson-Cicalese
  • ANTIOXIDANT-BASED POLY(ANHYDRIDE-ESTERS)
    Publication number: 20160130211
    Abstract: Certain embodiments of the invention provide antioxidant-based diacids and polymers comprising glycol groups as described herein, and methods of use thereof. In certain embodiments the polymers described herein are formulated as microspheres or hydrogels. Described herein is the chemical incorporation of antioxidants, e.g., coumaric acid, ferulic acid, and sinapic acid, into a polymer backbone for use, e.g., in applications for localized release and rapid delivery. As provided, the chemical composition of the linker molecules used (of which hold together two bioactives via ester linkages) may be used to vary the hydrophilicity of the polymer. The bioactive release rate may also be altered for a tunable release delivery system, allowing for increased bioactive release compared to other linkers previously utilized.
    Type: Application
    Filed: May 29, 2014
    Publication date: May 12, 2016
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Kathryn Uhrich, Michelle Morano
  • Electrochemically self assembled batteries
    Patent number: 9331357
    Abstract: The present invention relates to in situ formation of a single-layered electrochemical cell comprising a full tri-layer battery structure containing a discrete positive electrode, solid state electrolyte, and negative electrode from self-assembled nanocomposites. The single layered cell makes it possible to fabricate cells in three dimensions resulting in a very high energy density power source within very small and/or complex dimensions.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: May 3, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Glenn G. Amatucci, Irene Plitz, Fadwa Badway
  • Topoisomerase inhibitors
    Patent number: 9321781
    Abstract: The invention provides compounds of formula I: (I) wherein A, B, W, Y, Z, R1, R3 and R4 have any of the meanings defined in the specification and their salts as well as additional compounds and their salts. The invention also provides pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer, a bacterial infection or a fungal infection using compounds of the invention.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: April 26, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. Lavoie, Ajit K. Parhi
  • NEAR INFRARED LABEL AND METHODS OF USE THEREOF
    Publication number: 20160106867
    Abstract: The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.
    Type: Application
    Filed: May 8, 2014
    Publication date: April 21, 2016
    Applicants: Rutgers, The State University of New Jersey, New Jersey Institute of Technology
    Inventors: Arkady Mustaev, David S. Perlin, Laura Wirpsza
  • Cyclic dinucleosides
    Patent number: 9315523
    Abstract: Provided herein are compounds of formula Ia: and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula Ia, processes for preparing compounds of formula Ia, intermediates useful for preparing compounds of formula Ia and therapeutic methods using compounds of formula Ia.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: April 19, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Roger A. Jones, Barbara L. Gaffney
  • Antibacterial agents: aryl myxopyronin derivatives
    Patent number: 9315495
    Abstract: The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: April 19, 2016
    Assignees: Rutgers, The State University of New Jersey, Provid Pharmaceuticals Inc.
    Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
  • Aromatization or dehydrocyclization of N-alkanes using soluble transition metal complexes
    Patent number: 9302954
    Abstract: The invention provides methods and compositions useful for synthesizing alkylaromatics from an n-alkanes.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: April 5, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Alan Goldman, Ritu Ahuja, William Schinski
  • Compositions and methods for immunodominant antigens
    Patent number: 9297803
    Abstract: Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: March 29, 2016
    Assignees: Immport Therapeutics, Inc., Rutgers, The State University of New Jersey
    Inventors: Philip Felgner, David Huw Davies, Xiaowu Liang, Maria Laura Gennaro
  • IN SITU EXFOLIATION METHOD TO FABRICATE A GRAPHENE-REINFORCED POLYMER MATRIX COMPOSITE
    Publication number: 20160083552
    Abstract: A method for forming a graphene-reinforced-polymer matrix composite by distributing graphite microparticles into a molten thermoplastic polymer phase comprising one or more molten thermoplastic polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase exfoliates the graphene successively with each event, until tearing of exfoliated multilayer graphene sheets occurs arid produces reactive edges on the multilayer sheets that react with and cross-link the one or more thermoplastic polymers; where the one or more thermoplastic polymers are selected from thermoplastic polymers subject to UV degradation.
    Type: Application
    Filed: April 18, 2014
    Publication date: March 24, 2016
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Thomas Nosker, Jennifer Lynch, Bernard Kear, Justin Hendrix, Gordon Chiu
  • Compositions and methods for delivering nucleic acid molecules and treating cancer
    Patent number: 9289505
    Abstract: The present invention provides compositions and methods for the delivery of nucleic acids to a cell. The present invention additionally provides compositions and methods for the treatment of a disease or disorder, particularly cancer. In a particular embodiment, the composition comprises at least one pharmaceutically acceptable carrier and at least one liposome or dendrimer comprising at least two chemotherapeutic agents with different mechanisms of action and at least two inhibitors of cellular drug resistance.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: March 22, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Tamara Minko, Lorna Rodriguez-Rodriguez, Olga B. Garbuzenko, Oleh Taratula, Vatsal Shah
  • Ddopamine receptor agonists to treat dyskinesia in parkinson's disease
    Patent number: 9289400
    Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: March 22, 2016
    Assignees: Drexel University, Rutgers, The State University of New Jersey
    Inventors: Sandhya Kortagere, Eldo V. Kuzhikandahil
  • Iridium catalyst complexes and C—H bond activated products therefrom
    Patent number: 9289759
    Abstract: Provided is a novel iridium catalyst complex which is useful in the dehydrogenation of alkanes. The iridium complex comprises the metal iridium atom complexed with a benzimidazolyl-containing ligand. The iridium atom can be coordinated with the nitrogen atoms in the benzimidazolyl-containing ligand to form an NCN pincer ligand complex. In another embodiment, the iridium catalyst is used, with or without a co-catalyst, in a dehydrogenation reaction converting alkanes to olefins. The reaction can be in a closed or open system, and can be run in a liquid or gaseous phase.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: March 22, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Alan Stuart Goldman, Robert Timothy Stibrany
  • Efficient and recyclable heterogeneous nanocatalysts
    Patent number: 9283545
    Abstract: Efficient and recyclable heterogeneous nanocatalysts and methods of synthesizing and using the same are provided.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: March 15, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Tewodros Asefa, Ankush V. Biradar, Yanfei Wang
  • Process for alkane oligomerization
    Patent number: 9278894
    Abstract: Provided is a process for preparing oligomers from an alkane. The process comprises (a) contacting an alkane under dehydrogenation conditions in the presence of a dehydrogenation catalyst such as an iridium catalyst complex comprising iridium complexed with a benzimidiazolyl-containing ligand to form olefins, and (b) contacting the olefins prepared in step (a) under oligomerization conditions with an oligomerization catalyst such as a nickel, platinum or palladium metal catalyst complex comprising the metal complexed with a nitrogen containing bi- or tridentate ligand to prepare oligomers of the olefins, and hydrogenating the olefin oligomers. In one embodiment, the ligands of the catalyst complexes in step (a) and step (b) can be the same.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: March 8, 2016
    Assignees: Chevron U.S.A. Inc., Rutgers, The State University of New Jersey
    Inventors: Alan Stuart Goldman, Robert Timothy Stibrany, William L. Schinski
  • Autodissemination of an insect-growth regulator for insect management
    Patent number: 9265247
    Abstract: The described invention provides a gel formulation of a composition comprising at least one insecticide in an amount effective to control an insect larval population, an apparatus for autodissmenination of an insecticide for insect management containing (1) a cap component, (2) a cup component, and (3) a mesh component, a method and a system for autodissemination for effectively controlling an insect larval population. Also disclosed is an improvided biphasic autodissemination station for control of undesirable insect populations.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: February 23, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Randy Gaugler, Devi Suman, Yi Wang