Abstract: Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.
Type:
Application
Filed:
February 16, 2006
Publication date:
August 7, 2008
Applicant:
Ruthers, The State University of New Jersey
Inventors:
Patrick J. Sinko, Stanley Stein, Simi Gunaseelan, Shahriar Pooyan, Li Wan, Xiaoping Zhang