Abstract: The present disclosure provides a hydrogel composition comprising an interpenetrating polymer network (IPN) containing a biopolymer, a first synthetic polymer and a second synthetic polymer in which a contained community of live human MSCs is embedded. The collagen polymer matrix described (a) allows the embedded cells to remain in place or to migrate over short distances; (b) allows diffusion of small molecules, particularly growth factors produced by the cells or provided as a supplement, and EVs released by the cells to support the recovery of periodontium tissue function following injury.
Type:
Application
Filed:
March 20, 2023
Publication date:
September 21, 2023
Applicant:
RVO 2.0, INC., D/B/A OPTICS MEDICAL
Inventors:
Gabriel N. Njikang, Alan Ngoc Le, Beverly W. Lubit
Abstract: A corneal device comprising a base surface and a top surface, and having a water content ranging from about 78%-92% (w/w), inclusive. The corneal device can be used to treat, for example without limitation, ectatic corneal disease by supporting corneal structure weakened by the disease and/or changing an anterior curvature of the cornea.