Abstract: Here provided are a salt of Z)—O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate with an L-lysine addition in crystalline form and methods of making and using the same.
Type:
Grant
Filed:
December 12, 2014
Date of Patent:
February 14, 2017
Assignee:
RxBio, Inc.
Inventors:
Rama Krishna Reddy Singidi, Veeresh Gududuru, Mahmoud Mirmehrabi, Karin Emmons Thompson, Gabor Jozsef Tigyi, Charles Ryan Yates, Jurriaan Strobos
Abstract: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.