Abstract: A trocar-cannula complex for use in minimally invasive surgical procedures performed through a port site of a patient and in the delivery of biologically active agents to the patient includes a trocar and a cannula. The cannula includes a tubular structure with a central lumen receiving the trocar and an outer surface adapted to interface with tissue at the port site. A first delivery mechanism is associated with the cannula for delivering a first biologically active agent to a patient and a second delivery mechanism is associated with the cannula for delivery of a second biologically active agent to the patient. Various other manners of delivering the agents are also disclosed.