Abstract: A method of lyophilizing an oxazaphosphorin and a preparation produced thereby including dissolving an oxazaphosphorin in water, adding an amino acid to a molar ratio of between 1 to 10 amino acid to 1 oxazaphosphorin to produce a mixture and lyophilizing said mixture to remove said water, is disclosed.
Type:
Grant
Filed:
December 17, 1998
Date of Patent:
October 26, 1999
Assignee:
S.P. Pharmaceuticals
Inventors:
Michael J. Marek, Garnet G. Smith, Thomas R. Kovalcik