Patents Assigned to SABANCI ÜNIVERSITESI
-
Publication number: 20240100095Abstract: The invention provides modified Natural Killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex. These NK cells are used for T cell receptor (TCR) gene therapy in order to circumvent any risk of mispairing of the TCR ? and ? chains and to provide Major Histocompatibility Complex (MHC)-restricted antigen-specific cytotoxicity to the NK cells. The invention additionally provides methods for producing the modified NK cells, therapeutic compositions including the modified NK cells, and methods for using the modified NK cells in therapy of cancer, viral infections, autoimmunity, and graft versus host disease (GvHD).Type: ApplicationFiled: September 11, 2023Publication date: March 28, 2024Applicants: NOVA SOUTHEASTERN UNIVERSITY, SABANCI ÜNIVERSITESIInventors: Tolga SUTLU, Adil Doganay DURU, Batu ERMAN
-
Publication number: 20240014441Abstract: A polyoxazoline-based electrolyte and a network formed by crosslinking of the electrolyte through its secondary amine groups with an epoxy resin are provided. The network is designed as a multifunctional energy storage system that is capable of transferring mobile lithium cations through the passageways present in its structure. The present invention also relates to a method that is used to obtain such a network and electrolyte.Type: ApplicationFiled: July 27, 2020Publication date: January 11, 2024Applicant: SABANCI ÜNIVERSITESIInventors: Leila Haghighi POUDEH, Mehmet YILDIZ, Yusuf Ziya MENCELOGLU, Bekir DIZMAN, Serkan UNAL
-
Patent number: 11752172Abstract: The invention provides modified Natural Killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex. These NK cells are used for T cell receptor (TCR) gene therapy in order to circumvent any risk of mispairing of the TCR a and ? chains and to provide Major Histocompatibility Complex (MHC)-restricted antigen-specific cytotoxicity to the NK cells. The invention additionally provides methods for producing the modified NK cells, therapeutic compositions including the modified NK cells, and methods for using the modified NK cells in therapy of cancer, viral infections, autoimmunity, and graft versus host disease (GvHD).Type: GrantFiled: January 4, 2018Date of Patent: September 12, 2023Assignees: NOVA SOUTHEASTERN UNIVERSITY, SABANCI ÜNIVERSITESIInventors: Tolga Sutlu, Adil Doganay Duru, Batu Erman
-
Patent number: 11573034Abstract: A device including a liquid's flow path having an upstream side and a downstream side, a plurality of flow restrictive elements providing material communication between the upstream side to the downstream side, a thermoelectric generator or a thermophotovoltaic cell in thermal connection with a portion of the device located at the downstream side with respect to the plurality of flow restrictive elements. The portion is provided with roughness elements for, in use, contacting a fluid flowing through the device and facilitating collapse of cavitation bubbles.Type: GrantFiled: August 9, 2016Date of Patent: February 7, 2023Assignee: SABANCI ÜNIVERSITESIInventor: Ali Kosar
-
Patent number: 10954377Abstract: An admixture including at least one copolymer having a backbone. The backbone including at least one electrically charged monomer. The at least one copolymer is a grafted copolymer having mean molecular weight within a range between 600 g/mol and 3000 g/mol on side chains of the grafted copolymer. An additive manufacturing ink, Filament of the additive manufacturing ink, and inkjet printing ink including the admixture.Type: GrantFiled: September 26, 2016Date of Patent: March 23, 2021Assignee: SABANCI ÜNIVERSITESIInventors: Özge Akbulut, Omid Akhlaghi, Amin Hodaei, Dilek Sezer
-
Patent number: 10837604Abstract: A flow system for avoiding particle agglomeration in nanofluids, including a flow restrictive element, wherein the flow restrictive element in use provides sudden expansion to the fluid such that cavitation takes place the fluid upon exiting the flow restrictive element. The flow system includes the flow restrictive element having a hydraulic diameter within a range between 0.5 ?m and 250 ?m, a vicinity of the flow restrictive element is provided with a heater, adapted to heat the nanofluid in the vicinity of the flow restrictive element.Type: GrantFiled: October 22, 2015Date of Patent: November 17, 2020Assignees: SABANCI ÜNIVERSITESI, OZYEGIN ÜNIVERSITESIInventors: Ali Kosar, Kürsat Sendur, Mustafa Pinar Mengüc
-
Publication number: 20200238621Abstract: A method for automatic printing of a three dimensional heterogeneous structure in accordance with a computer-aided design procedure, including the steps of: aspirating a first portion consisting of a first material (M1) in liquid form, from a first liquid container into a capillary (C); aspirating a second portion consisting of a second material (M2) in liquid form different than the first material (M1), from a second liquid container into said capillary (C), such that the first portion and the second portion constitute longitudinally different parts of a longitudinally heterogeneous filament (F) encompassed by the capillary (C); and extraction of the filament (F) from the capillary (C) thus laying it as a portion of a printed layer.Type: ApplicationFiled: June 21, 2016Publication date: July 30, 2020Applicant: SABANCI ÜNIVERSITESIInventors: Bahattin KOC, Navid KHANI, Ali NADERNEZHAD
-
Publication number: 20200182514Abstract: A device including a liquid's flow path having an upstream side and a downstream side, a plurality of flow restrictive elements providing material communication between the upstream side to the downstream side, a thermoelectric generator or a thermophotovoltaic cell in thermal connection with a portion of the device located at the downstream side with respect to the plurality of flow restrictive elements. The portion is provided with roughness elements for, in use, contacting a fluid flowing through the device and facilitating collapse of cavitation bubbles.Type: ApplicationFiled: August 9, 2016Publication date: June 11, 2020Applicant: SABANCI ÜNIVERSITESIInventor: Ali KOSAR
-
Publication number: 20200032044Abstract: An admixture including at least one copolymer having a backbone. The backbone including at least one electrically charged monomer. The at least one copolymer is a grafted copolymer having mean molecular weight within a range between 600 g/mol and 3000 g/mol on side chains of the grafted copolymer. An additive manufacturing ink, Filament of the additive manufacturing ink, and inkjet printing ink including the admixture.Type: ApplicationFiled: September 26, 2016Publication date: January 30, 2020Applicant: SABANCI ÜNIVERSITESIInventors: Özge AKBULUT, Omid AKHLAGHI, Amin HODAEI, Dilek SEZER
-
Publication number: 20190365812Abstract: The invention provides modified Natural Killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex. These NK cells are used for T cell receptor (TCR) gene therapy in order to circumvent any risk of mispairing of the TCR a and ? chains and to provide Major Histocompatibility Complex (MHC)-restricted antigen-specific cytotoxicity to the NK cells. The invention additionally provides methods for producing the modified NK cells, therapeutic compositions including the modified NK cells, and methods for using the modified NK cells in therapy of cancer, viral infections, autoimmunity, and graft versus host disease (GvHD).Type: ApplicationFiled: January 4, 2018Publication date: December 5, 2019Applicants: NOVA SOUTHEASTERN UNIVERSITY, SABANCI ÜNIVERSITESIInventors: Tolga SUTLU, Adil Doganay DURU, Batu ERMAN
-
Publication number: 20190049071Abstract: The present invention proposes a flow system for avoiding particle agglomeration in nanofluids, comprising a flow restrictive element which in use provides sudden expansion to the fluid such that cavitation takes place in the fluid upon exiting the flow restrictive element.Type: ApplicationFiled: October 22, 2015Publication date: February 14, 2019Applicants: SABANCI ÜNIVERSITESI, OZYEGIN ÜNIVERSITESIInventors: Ali KOSAR, Kürsat SENDUR, Mustafa Pinar MENGÜC
-
Patent number: 10166330Abstract: A pharmaceutical drug delivery system having a base (1) comprising at least two inlets (2), an outlet (20) and a passive mixing chamber (7) having micro pin fins (8) with heights in the range of 10 to 100???? characterized in that the base (1) is selectively coated with nanostructures which are made of a material different than the material of said base, such that the base (1) comprises a plurality of regions R1 to RN each having a different nanostructure coating intensity, and such that a surface tension gradient is established among regions R1 to RN for promoting fluid flow towards the outlet (20). The present invention further proposes a method for obtaining a pharmaceutical drug delivery system.Type: GrantFiled: March 12, 2015Date of Patent: January 1, 2019Assignee: SABANCI ÜNIVERSITESIInventors: Ali Kosar, Osman Yavuz Perk
-
Patent number: 10106460Abstract: The present invention proposes a polycarboxylate ether-based additive having the general formula (I) for use as flow modifier in suspensions. The present invention further proposes a method for obtainment of such additive, wherein the method comprises the sequential steps of esterification of polyethylene glycol (PEG) with maleic anhydride (MA) and thus obtainment of a chemical product (PEGMA); and free radical polymerization in a mixture comprising acrylic acid (AA), 2-acrylamido-2 methylpropanesulfonic acid (AMPS) and PEGMA as reactants, further comprising water and an initiator, initial pH value of said mixture is within the range between 7.5 and 8.5, and any free oxygen is removed from the mixture throughout the free radical polymerization.Type: GrantFiled: February 15, 2016Date of Patent: October 23, 2018Assignee: SABANCI ÜNIVERSITESIInventors: Yusuf Menceloglu, Omid Akhlaghi, Özge Akbulut
-
Publication number: 20180135207Abstract: The present invention discloses an electrospinning composition comprising a catalyst and a functionalized polymer or copolymer bearing one or more epoxy ring. The mixture further comprises an anhydride, preferably phthalic anhydride as a cross-linking agent. Wherein a molar ratio of epoxy to anhydride in the electrospinning composition is within the range of 1:1 to 50:1. The present invention further discloses a preparation method of the electrospinning composition and an electrospun nano-/submicrostructures prepared using the method and composite material comprising the electrospun nano-/submicrostructures.Type: ApplicationFiled: May 22, 2015Publication date: May 17, 2018Applicant: SABANCI ÜNIVERSITESIInventors: Melih PAPILA, Ayca ÜRKMEZ, Kaan BILGE, Eren SIMSEK, Yusuf Z. MENCELOGLU, Elif Özden YENIGUN
-
Patent number: 9851706Abstract: A network (100) for replacement of a living tissue, said network is a scaffold-free artificial hollow biological tissue network comprising a plurality of longitudinal multicellular aggregates (11) arranged in a plurality of bioprinted layers (22) which are located on top of one another, further comprising an inner surface (20) and an outer surface (21), wherein at least one of said bioprinted layers (22) is in shape of a planar closed loop such that a conduit for conveying fluids is defined, and said longitudinal multicellular aggregate (11) is a mixture of at least two cell types. Also a method for obtaining said longitudinal multicellular aggregate, and a further method for biomodeling and planning said network are proposed.Type: GrantFiled: May 29, 2015Date of Patent: December 26, 2017Assignee: SABANCI ÜNIVERSITESIInventors: Bahattin Koç, Can Küçükgül, Saime Burçe Özler
-
Patent number: 9850572Abstract: The present invention proposes a production method for obtainment of three-dimensional closed graphene-based nano-/microstructures (10) using a coaxial multilayer core-shell production process (1000) comprising a coaxial flow system (100) having a first flow path (101) and a first fluid exit (1011) at an end of said first flow path; and a second flow path (102) circumferentially surrounding said first flow path (101), said second flow path having a second fluid exit (1021); wherein a first fluid (1) flows through the first flow path and exits through the first fluid exit (1011); and a second fluid (2) which is immiscible with the first fluid (1) under the conditions where said production method is conducted, flows through the second flow path (102) and exits through the second fluid exit (1021) such that the second fluid (2) circumferentially covers the first fluid (1) upon leaving the coaxial flow system (100); said second fluid (2) comprises a graphene-based material, a polymeric material and solvent.Type: GrantFiled: October 20, 2015Date of Patent: December 26, 2017Assignee: SABANCI ÜNIVERSITESIInventors: Yusuf Ziya Menceloglu, Burcu Saner Okan, Mehmet Yildiz
-
Publication number: 20170072138Abstract: A pharmaceutical drug delivery system having a base (1) comprising at least two inlets (2), an outlet (20) and a passive mixing chamber (7) having micro pin fins (8) with heights in the range of 10 to 100???? characterized in that the base (1) is selectively coated with nanostructures which are made of a material different than the material of said base, such that the base (1) comprises a plurality of regions R1 to RN each having a different nanostructure coating intensity, and such that a surface tension gradient is established among regions R1 to RN for promoting fluid flow towards the outlet (20). The present invention further proposes a method for obtaining a pharmaceutical drug delivery system.Type: ApplicationFiled: March 12, 2015Publication date: March 16, 2017Applicant: SABANCI ÜNIVERSITESIInventors: Ali KOSAR, Osman Yavuz PERK
-
Patent number: 9566205Abstract: It is proposed a design and control of series elastic holonomic mobile platform, aimed to administer therapeutic table-top exercises to patients who have suffered injuries that affect the function of their upper extremities. The proposed mobile platform is a low-cost, portable, easy-to-use rehabilitation device for home use. It consists of four actuated Mecanum wheels and a compliant, low-cost, multi degree-of freedom Series Elastic Element as its force sensing unit. Thanks to its series elastic actuation, it is highly backdriveable and can provide assistance/resistance to patients, while performing omni-directional movements on plane. The device helps improving accuracy and effectiveness of repetitive movement therapies completed at home, while also providing quantitative measures of patient progress.Type: GrantFiled: April 11, 2014Date of Patent: February 14, 2017Assignee: SABANCI ÜNIVERSITESIInventor: Volkan Patoglu
-
Publication number: 20160236982Abstract: The present invention proposes a polyczuboxylate ether-based additive having the general formula (I) for use as flow modifier in suspensions. The present invention further proposes a method for obtainment of such additive, wherein the method comprises the sequential steps of esterification of polyethylene glycol (PEG) with maleic anhydride (MA) and thus obtainment of a chemical product (PEGMA) and free radical polymerization in a mixture comprising acrylic acid (AA), 2-acrylamido-2 methylpropanesulfonic acid (AMPS) and PEGMA as reactants, further comprising water and an initiator, initial pH value of said mixture is within the range between 7.5 and 8.5, and any free oxygen is removed from the mixture throughout the free radical polymerization.Type: ApplicationFiled: February 15, 2016Publication date: August 18, 2016Applicant: SABANCI ÜNIVERSITESIInventors: Yusuf MENCELOGLU, Omid AKHLAGHI, Özge AKBULUT
-
Patent number: 9324745Abstract: The present invention presents unit cell architecture for infrared imaging, which has two input stages covering for both low and high light levels, and automatic input selection circuitry inside to extend dynamic range. The invention mainly helps to extend dynamic range of near visible (NIR) and short wave infrared (SWIR) image sensors by improving SNR value. The idea is applicable to not only infrared bands including NIR, SWIR, MWIR and LWIR but also full spectrum light.Type: GrantFiled: December 7, 2012Date of Patent: April 26, 2016Assignee: SABANCI ÜNIVERSITESIInventors: Melik Yazici, Ömer Ceylan, Hüseyin Kayahan, Yasar Gürbüz