Patents Assigned to Sage Bionetworks
  • GENETICALLY MODIFIED MOUSE MODELS OF ALZHEIMER'S DISEASE
    Publication number: 20210195879
    Abstract: The present disclosure provides a genetically modified mouse comprising a genomic nucleic acid encoding human APOE4, a genomic nucleic acid encoding mouse TREM2 modified to include a R47H substitution, and at least one genomic modification selected from the group consisting of: (a) a genomic nucleic acid encoding mouse ABCA7 modified to include an A 1541 G substitution; (b) a genomic nucleic acid encoding mouse APP modified to include G601R, F606Y, and R609H substitutions; (c) a genomic nucleic acid encoding mouse PLCG2 modified to include a M28L substitution; (d) a genomic nucleic acid encoding mouse MTHFR modified to include a A262V substitution; (e) an inactivated Ceacam1 allele; and (f) an inactivated Il1rap allele. Methods of producing the genetically modified mouse and methods of using the genetically modified mouse are also provided.
    Type: Application
    Filed: June 21, 2019
    Publication date: July 1, 2021
    Applicants: The Jackson Laboratory, Indiana University Research and Technology Corporation, Sage Bionetworks
    Inventors: Gareth Howell, Gregory Carter, Michael Sasner, Stacey Rizzo, Harriet Williams, Bruce Lamb, Paul Territo, Adrian Oblak, Ben Logsdon, Lara Mangravite, Leah Graham
  • Methods for predicting age and identifying agents that induce or inhibit premature aging
    Patent number: 10718025
    Abstract: The invention provides for methods for predicting age of a subject based on the epigenome of the subject.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: July 21, 2020
    Assignees: The Regents of the University of California, Sage Bionetworks
    Inventors: Kang Zhang, Gregory Hannum, Trey Ideker, Stephen H. Friend, Justin Guinney
  • Methods for predicting age and identifying agents that induce or inhibit premature aging
    Patent number: 10087486
    Abstract: The invention provides for methods for predicting age of a subject based on the epigenome of the subject.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: October 2, 2018
    Assignees: The Regents of the University of California, Sage Bionetworks
    Inventors: Kang Zhang, Gregory Hannum, Trey Ideker, Stephen H Friend, Justin Guinney