Abstract: An improved quick-disconnect hose coupling comprising a female coupling half having a ball valve designed with positive interlocking means for retention of a male coupling half in a receptacle formed therein. The ball valve is enclosed in a housing and is arranged to be pivotable therein about an axis, such that the male coupling half communicates with a bore hole in the other end of the ball valve. Pivoting movement of the ball valve provides a flow connection by bringing the bore hole into communication with a hose connector element retained in the other end of the housing, while interlocking pins contained in the ball valve mechanically engage the male coupling half in the receptacle. In one embodiment, a releasable latch engages a contoured slot in the housing for providing positively defined valve operating positions, such that the mechanical connection is completed prior to and separate from the flow connection.