Abstract: An ultrasound-induced drug delivery system is described, using a drug carrier containing a plurality of nanobubbles and a high concentration of a drug in one microcapsule, and a method for preparing the drug delivery system, by generating the nanobubbles in an oil into which the drug is dissolved using a nanobubble generator, and then microencapsulating them. The drug delivery system has an effect of maximizing a drug delivery efficiency as the nanobubbles collapse or aggregate when the ultrasound is applied to the drug delivery system. Since the drug delivery system contains a plurality of nanobubbles within the microcapsules, it can also be used as a contrast agent, or can be used to simultaneously perform in vivo diagnosis and treatment.
Type:
Grant
Filed:
September 20, 2019
Date of Patent:
February 6, 2024
Assignees:
SAHMYOOK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, N TO B CO., LTD.
Abstract: Disclosed are an emulsion composition including oilgel capsules, a coating composition including the emulsion composition, and a method for preparing the same, as well as a method for coating a machine part with the coating composition. In particular, the compositions and machine parts have excellent wear resistance and increased production compared to an existing process of providing oilgel capsules as an overlay layer by mixing an organic solvent and a nonionic surfactant with an oilgel.
Type:
Application
Filed:
December 8, 2022
Publication date:
September 28, 2023
Applicants:
HYUNDAI MOTOR COMPANY, KIA CORPORATION, Sahmyook University Industry-Academic Cooperation Foundation
Inventors:
Hu Yeon Choi, In Woong Lyo, Myoung Hwan Park, Yu Ri Park, Geon Woo Lim, Chan Hyun Cho
Abstract: Proposed are an ultrasound-assisted drug delivery carrier containing a ligand linked with a drug through an ester bond, a phospholipid, and a PEGylated phospholipid, a composition for drug delivery including the drug delivery carrier, and a method of preventing or treating a disease including administering the composition to an individual other than a human and releasing a drug by subjecting the site of administration of the composition to ultrasound irradiation. The ultrasound-assisted drug delivery carrier containing a ligand linked with a drug through an ester bond, a phospholipid, and a PEGylated phospholipid can be provided in the form of microbubbles or nanobubbles, and is capable of accelerating drug release due to collapse of the bubbles and promotion of hydrolysis of the ester bond during ultrasound irradiation, making it possible to deliver the drug to a desired site with high efficiency.
Type:
Application
Filed:
August 27, 2020
Publication date:
October 6, 2022
Applicant:
SAHMYOOK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Abstract: An oil gel capsule includes an oil gel including an oil and a gelator, and at least one surfactant bonded to the oil gel. A contact part for a vehicle includes an overlay layer formed on a surface of the contact part, the overlay layer comprising oil gel capsules, wherein the oil gel capsules including an oil gel including an oil and a gelator, and at least one surfactant bonded to the oil gel.
Type:
Grant
Filed:
September 29, 2020
Date of Patent:
November 30, 2021
Assignees:
Hyundai Motor Company, Kia Motors Corporation, Sahmyook University Industry-Academic Cooperation Foundation
Inventors:
Jeong-Uk An, Hong-Wook Lee, In-Woong Lyo, Kyung-Ku Yeo, Do-Young Wang, Ju-Yeong An, Myoung-Hwan Park, Yu-Ri Park