Abstract: The present invention relates to virus-like particles of plant virus Cucumber Mosaic Virus (CMV), and in particular to modified VLPs of CMV comprising Th cell epitopes, in particular universal Th cell epitopes. Furthermore, these modified VLPs serve as, preferably, vaccine platform, for generating immune responses, in particular antibody responses, against antigens linked to said modified VLPs. The presence of the Th cell epitopes, in particular universal Th cell epitopes, led to a further increase in the generated immune response.
Type:
Grant
Filed:
October 20, 2015
Date of Patent:
January 14, 2020
Assignee:
SAIBA GMBH
Inventors:
Martin Bachmann, Andris Zeltins, Paul Pumpens
Abstract: The present invention relates to virus-like particles of plant virus Cucumber Mosaic Virus (CMV), and in particular to modified VLPs of CMV comprising Th cell epitopes, in particular universal Th cell epitopes. Furthermore, these modified VLPs serve as, preferably, vaccine platform, for generating immune responses, in particular antibody responses, against antigens linked to said modified VLPs. The presence of the Th cell epitopes, in particular universal Th cell epitopes, led to a further increase in the generated immune response.
Type:
Application
Filed:
October 20, 2015
Publication date:
November 2, 2017
Applicant:
SAIBA GMBH
Inventors:
Martin BACHMANN, Andris ZELTINS, Paul PUMPENS