Patents Assigned to Saint Louis University
  • METHOD FOR CONTROLLING PHASE TRANSFORMATION TEMPERATURE IN METAL ALLOY OF A DEVICE
    Publication number: 20110277890
    Abstract: An efficient method to reduce product wastes due to inaccurate transformation temperatures for shape memory products and parts, which provides a useful method for optimizing shape memory alloys phase transformation temperatures and mechanical properties by using heat treatment procedures below 250 degrees C. for extended dwell times.
    Type: Application
    Filed: May 17, 2010
    Publication date: November 17, 2011
    Applicant: Saint Louis University
    Inventors: John Gary Bledsoe, Berton Roy Moed, Dongfa Li
  • METHODS AND COMPOSITIONS FOR THE MANAGEMENT OF CARDIOVASCULAR DISEASE WITH OLIGONUCLEOTIDES
    Publication number: 20110281933
    Abstract: Disclosed are compositions and methods for treating cardiovascular disease and reducing the adverse effects induced by the administration of statins. In particular, disclosed is the use of antisense compounds to augment the expression of mirR-33 and associated genetic elements. In particular methods of the treatment of cardiovascular disease and the modulation of miR-33 levels is disclosed as well as treatment of the secondary effects including cholestasis, induced by the administration of statins is disclosed. Also disclosed is the treatment of Benign Recurrent Intrahepatic Cholestasis and reverse cholesterol transport. The disclosed methods and compositions may be practiced separately or co-administered with satins to reduce or treat statin induced secondary effects.
    Type: Application
    Filed: May 13, 2011
    Publication date: November 17, 2011
    Applicant: Saint Louis University
    Inventors: Angel Baldan, Tyler Marquart, Ryan Allen
  • Immobilized enzymes and uses thereof
    Patent number: 8048660
    Abstract: Disclosed are bioanodes comprising a quaternary ammonium treated Nafion® polymer membrane and a dehydrogenase incorporated within the treated Nafion® polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion conducting polymer membrane lies juxtaposed to a polymethylene green redox polymer membrane, which serves to electro-oxidize the reduced adenine dinucleotide. The bioanode is used in a fuel cell to produce high power densities.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: November 1, 2011
    Assignee: Saint Louis University
    Inventors: Shelley D. Minteer, Niki L. Akers, Christine M. Moore
  • METHOD FOR DETECTING LYSOSOMAL STORAGE DISEASES
    Publication number: 20110256563
    Abstract: A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood can be employed as a specimen. The assay can be performed by use of a polypeptide that is capable of specifically binding to a glycosaminoglycan-containing molecule. The polypeptide may be an antibody, or a polypeptide having an antigen-binding site of an antibody.
    Type: Application
    Filed: April 21, 2011
    Publication date: October 20, 2011
    Applicants: Saint Louis University, Seikagaku Corporation
    Inventors: Kazuo OKAMURA, Shuichi Miyaura, Shunji Tomatsu
  • COMPOSITIONS AND METHODS FOR TREATING HYPOPHOSPHATASIA
    Publication number: 20110250187
    Abstract: The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue.
    Type: Application
    Filed: March 24, 2011
    Publication date: October 13, 2011
    Applicant: Saint Louis University
    Inventors: Shunji Tomatsu, William Sly, Jeffrey Grubb, Tatsuo Nishioka, Ken-ichi Miyamoto, Seiji Yamaguchi
  • Method for detecting lysosomal storage diseases
    Patent number: 8003337
    Abstract: A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood can be employed as a specimen. The assay can be performed by use of a polypeptide that is capable of specifically binding to a glycosaminoglycan-containing molecule. The polypeptide may be an antibody, or a polypeptide having an antigen-binding site of an antibody.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: August 23, 2011
    Assignees: Seikagaku Corporation, Saint Louis University
    Inventors: Kazuo Okamura, Shuichi Miyaura, Shunji Tomatsu
  • Delivery of therapeutic agents to the bone
    Patent number: 7972593
    Abstract: This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: July 5, 2011
    Assignee: Saint Louis University
    Inventors: Shunji Tomatsu, Adriana Montaño-Suarez, Carlos J. Alméciga-Diaz, Luis Barrera
  • Method for detecting lysosomal storage diseases
    Patent number: 7951545
    Abstract: A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood can be employed as a specimen. The assay can be performed by use of a polypeptide that is capable of specifically binding to a glycosaminoglycan-containing molecule. The polypeptide may be an antibody, or a polypeptide having an antigen-binding site of an antibody.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: May 31, 2011
    Assignees: Seikagaku Corporation, Saint Louis University
    Inventors: Kazuo Okamura, Shuichi Miyaura, Shunji Tomatsu
  • Compositions and methods for treating hypophosphatasia
    Patent number: 7943126
    Abstract: The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: May 17, 2011
    Assignee: Saint Louis University
    Inventors: Shunji Tomatsu, William S Sly, Jeffrey H Grubb, Tatsuo Nishioka, Ken-ichi Miyamoto, Seiji Yamaguchi
  • Biosensors for detecting macromolecules and other analytes
    Patent number: 7939313
    Abstract: The invention generally provides molecular biosensors. In particular, the invention provides molecular biosensors having one or more aptamers. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.
    Type: Grant
    Filed: December 11, 2004
    Date of Patent: May 10, 2011
    Assignee: Saint Louis University
    Inventors: Tomasz Heyduk, Ewa Heyduk, Eric Knoll
  • DIAGNOSTIC METHOD FOR BIOMARKERS OF ADVERSE CORONARY EVENTS
    Publication number: 20110091980
    Abstract: A diagnostic method using biomarkers to predict future adverse coronary events is provided. More particularly, the present invention is directed to diagnostic tests for characterizing an individual's risk of developing or having cardiovascular disease. In certain embodiments, the method of the present invention quantitates the presence of elevated levels of chlorinated lipids derived from myeloperoxidase as a prognostic indicator of future adverse coronary events.
    Type: Application
    Filed: October 16, 2009
    Publication date: April 21, 2011
    Applicant: SAINT LOUIS UNIVERSITY
    Inventor: David A. Ford
  • BIOSENSORS FOR DETECTING MACROMOLECULES AND OTHER ANALYTES
    Publication number: 20110091893
    Abstract: The invention generally provides molecular biosensors. In particular, the invention provides molecular biosensors having one or more aptamers. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.
    Type: Application
    Filed: December 6, 2010
    Publication date: April 21, 2011
    Applicant: SAINT LOUIS UNIVERSITY
    Inventors: Tomasz Heyduk, Ewa Heyduk, Eric Knoll
  • Peptides for Inducing Heterosubtypic Influenza T Cell Responses
    Publication number: 20110076297
    Abstract: The present invention provides compositions and methods for generation of an anti-influenza immune response. In particular, conserved T cell epitopes within matrix protein and nucleoprotein components of influenza virus have been identified and further screened for those structures that will bind either or both of HLA I and II molecules. Methods for vaccinating subjects with formulations of such peptides for the treatment or prevention of influenza infaction also are described.
    Type: Application
    Filed: September 30, 2010
    Publication date: March 31, 2011
    Applicant: Saint Louis University
    Inventor: Daniel Hoft
  • COMPOSITIONS AND METHODS FOR INHIBITING OR INDUCING ADIPOGENESIS
    Publication number: 20110014275
    Abstract: This invention relates generally to compositions and methods which utilization nuclear receptors for regulating adipogenesis in cells. Specifically, the invention is directed to compositions which regulate transcription factor PPAR?, and enhance or inhibit the transcription of genes responsible for directing cell differentiation towards a pathway of adipogenesis. More specifically, disclosed herein is a novel polypeptide coactivator of PPAR?, and fragments thereof, which possess coactivator or corepressor activity. Also related are nucleotide sequences which express these polypeptides. Also disclosed is an interfering RNA that may be used to inhibit adipogenesis.
    Type: Application
    Filed: August 30, 2010
    Publication date: January 20, 2011
    Applicant: Saint Louis University
    Inventor: Dechun Li
  • Chimeral polypeptide composition for cross-placenta delivery
    Patent number: 7871624
    Abstract: The invention is directed to chimeral fusion proteins having an IgG1 antibody Fc portion and a lysosomal storage enzyme, particularly a Fc-GUS fusion protein useful in treating Sly's disease in an embryo or fetus. The invention is also directed to methods of treating in born errors of metabolism, particularly Sly's disease, in a fetus by delivering to a pregnant mother a Fc-MPS emzyme fusion protein.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: January 18, 2011
    Assignee: Saint Louis University
    Inventors: Jeffrey H. Grubb, William S. Sly
  • DIAGNOSTIC METHOD OF MUCOPOLYSACCHARIDOSES
    Publication number: 20110008810
    Abstract: Provision of a method for accurate diagnosis of mucopolysaccharidoses, including determining the level of glycosaminoglycan in a biological sample with high sensitivity and with ease.
    Type: Application
    Filed: July 26, 2010
    Publication date: January 13, 2011
    Applicant: Saint Louis University, a non-profit organization
    Inventors: Shunji Tomatsu, Toshihiro Oguma
  • Proteins with an attached short peptide of acidic amino acids
    Patent number: 7863238
    Abstract: Disclosed are a fusion protein comprising enzyme N-acetylgalactosamine-6-sulfate sulfatase and a short peptide consisting of 4-15 acidic amino acids attached to the enzyme on its N-terminal side, a pharmaceutical composition containing the fusion protein, and a method for treatment of type A Morquio disease using the fusion protein. Compared with the native enzyme protein, the fusion protein exhibits higher transferability to bone tissues and improved, higher stability in the blood.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: January 4, 2011
    Assignees: Saint Louis University, Kanazawa University, JCR Pharmaceuticals Co., Ltd.
    Inventors: Shunji Tomatsu, Ken'ichi Miyamoto, Masamichi Yamada, Yasuhiro Tosaka, Mana Yamada
  • THREE-COMPONENT BIOSENSORS FOR DETECTING MACROMOLECULES AND OTHER ANALYTES
    Publication number: 20100297654
    Abstract: The invention generally provides three-component molecular biosensors. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.
    Type: Application
    Filed: July 6, 2010
    Publication date: November 25, 2010
    Applicant: SAINT LOUIS UNIVERSITY
    Inventor: Tomasz Heyduk
  • Polypeptide fragment of constitutive coactivator of PPARgamma
    Patent number: 7834140
    Abstract: This invention relates generally to compositions and methods which utilization nuclear receptors for regulating adipogenesis in cells. Specifically, the invention is directed to compositions which regulate transcription factor PPAR?. and enhance or inhibit the transcription of genes responsible for directing cell differentiation towards a pathway of adipogenesis. More specifically, disclosed herein is a novel polypeptide coactivator of PPAR?, and fragments thereof, which possess coactivator or corepressor activity. Also related are nucleotide sequences which express these polypeptides. Also disclosed is an interfering RNA that may be used to inhibit adipogenesis.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: November 16, 2010
    Assignee: Saint Louis University
    Inventor: Dechun Li
  • Molecular biosensors for use in competition assays
    Patent number: 7811809
    Abstract: The invention generally provides molecular biosensors. The molecular biosensors are useful in competition assays to detect the presence of a target molecule.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: October 12, 2010
    Assignee: Saint Louis University
    Inventors: Tomasz Heyduk, Ling Tian