Abstract: Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.
Type:
Grant
Filed:
August 19, 2009
Date of Patent:
December 13, 2011
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Alexander Volkov
Abstract: Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxorubicin in biological fluids.
Type:
Grant
Filed:
April 30, 2009
Date of Patent:
November 8, 2011
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Shu He
Abstract: Use of busulfan amide as stabilized standards in immunoassays for quantifying the amount of busulfan in samples of human biological fluids, methods for carrying out said immunoassay and kits for use in said immunoassay.
Type:
Grant
Filed:
September 17, 2008
Date of Patent:
October 18, 2011
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Yunying Li
Abstract: Novel conjugates of busulfan and novel busulfan immunogens derived from ?-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.
Type:
Grant
Filed:
July 9, 2008
Date of Patent:
February 22, 2011
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Shu He
Abstract: Novel conjugates of 5-fluoro-uracil and novel 5-fluoro-uracil immunogens and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and monitoring of 5-fluoro-uracil in biological fluids.
Type:
Grant
Filed:
February 20, 2007
Date of Patent:
August 3, 2010
Assignee:
Saladax Biomedical Inc
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Dennis Stocker
Abstract: Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxorubicin in biological fluids.
Type:
Grant
Filed:
March 27, 2006
Date of Patent:
August 4, 2009
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Shu He
Abstract: Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in immunoassays for the quantification and monitoring of docetaxel in biological fluids.
Type:
Grant
Filed:
March 20, 2006
Date of Patent:
December 2, 2008
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Gregory Drake Lundell, Mahmoud Ahmed ElSohly, Waseem Gul
Abstract: Novel conjugates of busulfan and novel busulfan immunogens derived from ?-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.
Type:
Grant
Filed:
October 6, 2006
Date of Patent:
September 9, 2008
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Shu He
Abstract: The present invention provides a method for the enzymatic measurement of protein tyrosine kinase inhibitors in biological samples. The present invention also provides assay reagents and packaged kits useful for performing enzymatic measurement of imatinib mesylate and other bcr-abl protein kinase inhibitors in biological samples.
Type:
Grant
Filed:
November 14, 2005
Date of Patent:
November 27, 2007
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Katherine Salamone
Abstract: Novel conjugates of protected aldehyde active metabolites of cyclophosphamide including reagents and immunogens thereof and monoclonal antibodies generated by these immunogens, said reagents and immunogens useful in immunoassays for the monitoring of the active metabolites of cyclophosphamide in patients being treated with cyclophosphamide.
Type:
Grant
Filed:
July 20, 2005
Date of Patent:
October 2, 2007
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Dennis Stocker
Abstract: Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids.
Type:
Grant
Filed:
December 12, 2005
Date of Patent:
February 13, 2007
Assignee:
Saladax Biomedical, Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Dennis Stocker, Mahmoud Ahmed ElSohly, Waseem Gul
Abstract: Novel conjugates of busulfan and novel busulfan immunogens derived from ?-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.
Type:
Grant
Filed:
September 13, 2005
Date of Patent:
December 12, 2006
Assignee:
Saladax Biomedical Inc.
Inventors:
Salvatore J. Salamone, Jodi Blake Courtney, Shu He