Patents Assigned to Salpep Biotechnology, Inc.
  • Anti-inflammatory peptides
    Patent number: 7833986
    Abstract: Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutical compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the formula: X1-X2-X3 wherein X1 is selected from the group consisting of 2-amino-hexanoic acid; 2-amino-heptanoic acid; 2-amino-octanoic acid; cyclohexyl-substituted 2-amino-ethanoic acid, 2-amino-propanoic acid or 2-amino-butanoic acid and methionine; X2 is an acidic amino acid; and X3 is an aliphatic amino acid; or of a peptide of the formula: X4-X5 wherein X4 is an aromatic or aliphatic amino acid; and X5 is an acidic amino acid.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: November 16, 2010
    Assignee: Salpep Biotechnology Inc.
    Inventor: Ronald Mathison
  • Anti-inflammatory peptides
    Patent number: 7153835
    Abstract: Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutical compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the formula: X1-X2-X3 wherein X1 is selected from the group consisting of 2-amino-hexanoic acid; 2-amino-heptanoic acid; 2-amino-octanoic acid; cyclohexyl-substituted 2-amino-ethanoic acid, 2-amino-propanoic acid or 2-amino-butanoic acid and methionine; X2 is an acidic amino acid; and X3 is an aliphatic amino acid; or of a peptide of the formula: X4-X5 wherein X4 is an aromatic or aliphatic amino acid; and X5 is an acidic amino acid.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: December 26, 2006
    Assignee: Salpep Biotechnology, Inc.
    Inventor: Ronald Mathison
  • Peptides for treatment of inflammation and shock
    Patent number: 7094760
    Abstract: Submandibular peptides have been isolated and characterised and provide pharmaceutical compositions for the treatment or prevention of anaphylactic reactions, endotoxic reactions and SIRS-induced shock.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: August 22, 2006
    Assignee: Salpep Biotechnology, Inc.
    Inventors: Ronald Mathison, Joseph S. Davison, Dean Befus, Graham Moore
  • Peptides for treatment of inflammation and shock
    Patent number: 6852697
    Abstract: Submandibular peptides have been isolated and characterized and provide pharmaceutical compositions for the treatment or prevention of anaphylactic reactions, endotoxic reactions and SIRS-induced shock.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: February 8, 2005
    Assignee: Salpep Biotechnology, Inc.
    Inventors: Ronald Mathison, Joseph S. Davison, Dean Befus, Graham Moore
  • Treating allergic reactions and inflammatory responses with tri-and dipeptides
    Patent number: 6586403
    Abstract: This invention relates to methods and compositions of tripeptides and dipeptides having anti-inflammatory activities that can be used for the treatment of allergic and inflammatory reactions. A peptide of the formula: X-R.sub. 1 -R.sub.2 -R.sub.3 -Y  (I) or X-R.sub. 1 -R.sub.2 -Y  (II) wherein X is selected from the group consisting of H and acetyl; R.sub. 1 is selected from the group consisting of D or L-phenylalanine; tyrosine; tryptophan; phenylglycine; Nor-methylphenylalanine; cyclohexylalanine; and norleucine; R.sub.2 is selected from the group consisting of D or L-glutamate; and aspartate; and in the case of peptide (II), R.sub.3 is selected from the group consisting of glycine; D or L-alanine; beta-alanine; valine; leucine; isoleucine; sarcosine; and gamma-aminobutyric acid or another aliphatic amino acid; and Y is selected from the group consisting of OH and NH.sub.2, but excluding the dipeptides H-L-Phe-L-Glu-OH, H-L-Trp-L-Glu-OH, H-D-Phe-D-Glu-OH and H-D-Trp-D-Glu-OH.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: July 1, 2003
    Assignee: Salpep Biotechnology, Inc.
    Inventors: Ronald Mathison, Essam Metwally