Abstract: Provided is an ophthalmic pharmaceutical composition having a certain pH, comprising aflibercept as an active ingredient and an acetate salt buffering agent, wherein the composition is free of an ionic tonicity agent, remarkably reduces the formation of dimeric and multimeric impurities, and maintains the biological activity in a high level for a long time, under the accelerated and stress conditions as well as under the cold storage condition.
Type:
Grant
Filed:
October 13, 2017
Date of Patent:
May 12, 2020
Assignee:
SAM CHUN DANG PHARM. CO., LTD.
Inventors:
Guang-Jin Im, Byung-Jhip Ha, Na-Won Park, Yong-Seop Park
Abstract: Provided is an ophthalmic pharmaceutical composition having a certain pH, comprising aflibercept as an active ingredient and an acetate salt buffering agent, wherein the composition is free of an ionic tonicity agent, remarkably reduces the formation of dimeric and multimeric impurities, and maintains the biological activity in a high level for a long time, under the accelerated and stress conditions as well as under the cold storage condition.
Type:
Application
Filed:
October 13, 2017
Publication date:
May 30, 2019
Applicant:
SAM CHUN DANG PHARM. CO., LTD.
Inventors:
Guang-Jin IM, Byung-Jhip HA, Na-Won PARK, Yong-Seop PARK
Abstract: The present invention relates to a galenic preparation for prevention and treatment of hepatocarcinoma. More specifically, the present invention relates to a galenic preparation which comprises an injectable composition having a good preventive and therapeutic effect particularly against hepatitis B virus and containing 4 kinds of main natural drugs, i.e., Hedyotidis herba, Curcumae longae rhizoma, Polygonati cuspidati radix and Sophorae tonkinesis radix; and an oral composition having a preventive and therapeutic effect against fatty liver and hepatic cirrhosis and containing 10 kinds of natural drugs, i.e.
Abstract: The present invention relates to a pharmaceutical composition containing a combination of natural drugs for treatment of diabetes. More specifically, the present invention relates to a composition containing 17 kinds of main natural drugs, i. e. Cordyceps, Bezoar bovis, Carthami flos, Astragali radix, Hirudo, Polygoni cuspidati radix, Polygonati falcati rhizoma, Euonymi lignum suberalatum, Corni fructus, Moutan cortex, Lycii cortex radicis, Lycii fructus, Atractylodis rhizoma alba, Atractylodis rhizoma, Coptidis rhizoma, Puerariae radix and Rehmaniae radix crudae.
Type:
Grant
Filed:
October 30, 1997
Date of Patent:
June 29, 1999
Assignee:
Sam Chun Dang Pharm Co., Ltd.
Inventors:
Jung Sik Lee, Chung San Kong, Song Deuk Lee, Kyung Eun Kwak