Abstract: The present invention discloses the potential of Calebin A in inhibiting adipogenesis and applications thereof in obesity management. The present invention elucidates the potential of Calebin A to favorably modulate biochemical markers associated with obesity. Notable biomodulatory properties of Calebin A include inhibiting leptin production, increasing adiponectin expression and inhibiting local (adipocyte) and systemic inflammation caused by pro-inflammatory cytokines Tumor Necrosis Factor (TNF-?), Interleukin-6 (IL-6) and Interleukin-1 (IL-1?).
Abstract: The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin.
Type:
Grant
Filed:
August 7, 2007
Date of Patent:
February 26, 2013
Assignee:
Sami Labs Limited
Inventors:
Muhammed Majeed, Renukeshwar H Chandramouli, Kalyanam Nagabhushanam, Rattan Sood, Subbalakshmi Prakash, Susmitha Anand
Abstract: The present invention relates to preservation of cosmetic formulations. More specifically, the present invention relates to a preservative composition for cosmetic formulations comprising thymol, monolaurin and magnolol obtained from supercritical fluid extracts of Magnolia officinalis.
Type:
Grant
Filed:
April 2, 2012
Date of Patent:
December 11, 2012
Assignee:
Sami Labs Limited
Inventors:
Muhammed Majeed, Beena Bhat, Garima Agarwal
Abstract: The present invention provides a composition comprising polyisoprenylated benzophenone derivative and at least one component selected from stilbene derivative and anthocyanins. The composition inhibits adipogenesis and is therefore useful in treating obesity or weight loss.
Abstract: The invention relates to methods of treatment and pharmaceutical compositions of new chemical compounds that inhibit the various enzymes in the arachidonic acid pathway implicated in inflammatory disease conditions.
Type:
Grant
Filed:
October 12, 2007
Date of Patent:
May 27, 2008
Assignee:
Sami Labs Limited
Inventors:
Muhammed Majeed, Kalyanam Nagabushnam, Rajendran Ramanujam, Subbalakshmi Prakash
Abstract: The invention relates to new chemical compounds that inhibit the various enzymes in the arachidonic acid pathway implicated in inflammatory disease conditions.
Type:
Grant
Filed:
March 11, 2007
Date of Patent:
May 13, 2008
Assignee:
Sami Labs Limited
Inventors:
Muhammed Majeed, Kalyanam Nagebhuananam, Rajendran Ramanujam, Subbalakshmi Prakash
Abstract: Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.
Type:
Grant
Filed:
January 23, 2007
Date of Patent:
August 7, 2007
Assignee:
Sami Labs Limited
Inventors:
Muhammed Majeed, Samuel Manoharan Thomas, Kalyanam Nagabhushanam, Sivaprakash Kurumanghat Balakrishnan, Subbalakshmi Prakash
Abstract: A process for the manufacture of new crystalline salts of N-[2-(dimethylamino)ethyl]-1,2-dithiolane-3-pentanamide (racemic and chiral forms) is described. Such salts are stable, crystalline and have very good solubility in water. The salts exhibit antioxidant properties. They inhibit collagenase and elastase enzymes. They have excellent anti acne activity in addition tyrosinase inhibition. They are, by themselves and in combination with other known agents, important cosmetic ingredients.
Type:
Grant
Filed:
June 15, 2004
Date of Patent:
April 10, 2007
Assignee:
Sami Labs Limited
Inventors:
Muhammed Majeed, Kalyanam Nagabhushanam
Abstract: The invention describes compositions and methods containing nonconventional plant materials, and more particularly the species Flemingia macrophylla and Careya arborea, that help to maintain normal blood sugar levels in humans and animals. The method of preparation of such compositions and methods of quantifying active principles therein are also described. A Metformin-like compound were found to be the active hypoglycemic principle in Flemingia macrophylla and Careya arborea root bark. The compositions of the invention were found to be safe for therapeutic use.
Type:
Grant
Filed:
May 25, 2004
Date of Patent:
January 9, 2007
Assignee:
Sami Labs Limited
Inventors:
Muhammed Majeed, Subbalakshmi Prakash, Shipra Roy, Venu Agarwal
Abstract: The invention provides a method for increasing serum high density lipoprotein (HDL) cholesterol levels, and lowering serum levels of Lipoprotein (a) and C-reactive protein, as well as a suitable composition comprising a) a vegetable protein, b) a natural antioxidant compound, c) a natural anti-inflammatory compound, d) a bioavailable source of selenium, e) a natural blend of long chain aliphatic alcohols termed policosanol; and f) a natural bioavailability enhancer.
Abstract: The invention relates to the effective use of compositions containing a specially prepared oil from Vitex agnus castus berry as a potent anti-acne agent which is to be applied topically. The invention also describes the process of fractionation of the oil, identification of the active component using bioautographic technique, and the use of the active component as an anti-acne agent.
Type:
Application
Filed:
November 22, 2004
Publication date:
May 25, 2006
Applicant:
SAMI LABS LIMITED
Inventors:
Muhammed Majeed, Farha Shaheen, Subbalakshmi Prakash
Abstract: The invention discloses a method to prepare concentrates from Allium sativum Linn. (Garlic) bulbs naturally enriched with an unique composition of organic selenium compounds and the use of such concentrates in nutritional supplement compositions for human and animal use. The resulting compositions provide a safe and efficacious means of providing supplemental amounts of the essential trace mineral nutrient selenium for diverse health benefits.
Type:
Grant
Filed:
October 9, 2003
Date of Patent:
March 21, 2006
Assignee:
Sami Labs Limited
Inventors:
Muhammed Majeed, Rajinder Kumar Bammi, Vladimir Badmaev, Subbalakshmi Prakash, Nagabhushanam Kalyanam
Abstract: The invention describes compositions and methods containing nonconventional plant materials, and more particularly the species Flemingia macrophylla and Careya arborea, that help to maintain normal blood sugar levels in humans and animals. The method of preparation of such compositions and methods of quantifying active principles therein are also described. A Metformin-like compound were found to be the active hypoglycemic principle in Flemingia macrophylla and Careya arborea root bark. The compositions of the invention were found to be safe for therapeutic use.
Type:
Application
Filed:
May 25, 2004
Publication date:
January 5, 2006
Applicant:
SAMI LABS LIMITED
Inventors:
Muhammed Majeed, Subbalakshmi Prakash, Shipra Roy, Venu Agarwal
Abstract: Aqueous solutions of diterpenes such as Forskolin, its congeners, analogs and derivatives, up to approximately 6% concentration, are prepared using suitably substituted cyclodextrin as a solubilizing agents. In the absence of cyclodextrin, some diterpenes such as Forskolin are soluble in water only to concentrations of about 0.001%. Such aqueous solutions find applications in topical and systemic use, as pharmaceutical, cosmeceutical, nutraceutical preparations containing diterpenes such as Forskolin and congeners.
Type:
Grant
Filed:
September 8, 2003
Date of Patent:
November 1, 2005
Assignee:
Sami Labs Limited
Inventors:
Muhammed Majeed, Arvind Kumar, Kalyanam Nagabhushanam, Subbalakshmi Prakash
Abstract: Convenient processes are described for the synthesis of L-Se-methyselenocysteine from chloroalanine derivatives. The process is easily extendable to other selenium substituted amino acids. DL-Se-methyselenocysteine is easily obtained by a benzaldehyde-catalyzed racemization of L-Se-methyselenocysteine.