Patents Assigned to Samsung Bioepis
-
Publication number: 20220213431Abstract: The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.Type: ApplicationFiled: August 13, 2021Publication date: July 7, 2022Applicants: Biogen MA Inc., Samsung BioepisInventors: William C. Yang, Yao-Ming Huang, Marty Sinacore, Thomas Ryll, Jiuyi Lu, Jaesun Lee, Kyngju Lee, Hyoung Taek Lim, Eunchong Yang
-
Patent number: 11124760Abstract: The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.Type: GrantFiled: March 24, 2015Date of Patent: September 21, 2021Assignees: Biogen MA Inc., Samsung BioepisInventors: William Yang, Yao-Ming Huang, Marty Sinacore, Thomas Ryll, Jiuyi Lu, Jaesun Lee, Kyngju Lee, Hyoung Taek Lim, Eunchong Yang
-
Patent number: 10676772Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.Type: GrantFiled: April 16, 2018Date of Patent: June 9, 2020Assignees: Biogen MA Inc., Samsung BioepisInventors: William C. Yang, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Liu Tsang, Thomas Ryll, Sangil Lee, Dae Sung Lee
-
Publication number: 20200062822Abstract: The invention provides a composition comprising an anti-tumor necrosis factor (TNF)-alpha polypeptide, wherein the composition produces a reduced level of immunogenicity when administered to a subject, as well as a treatment method involving the administration of the composition.Type: ApplicationFiled: October 31, 2019Publication date: February 27, 2020Applicants: SAMSUNG BIOEPIS CO., LTD., BIOGEN MA INC.Inventors: Jeehoon GHIL, Yoonseok LEE, Songyoung KIM, Orlando A. JAQUEZ, Robert S. GRONKE
-
Publication number: 20190330319Abstract: A stable aqueous composition comprising (a) about 10 to about 100 mg/ml of an anti-C5 antibody, (b) a surfactant, (c) a stabilizer, and (d) a buffer having a pH of about 5.0 to about 7.8, wherein the stabilizer is trehalose, sucrose, sorbitol, arginine, or a combination thereof is provided. In a particular embodiment, the stable aqueous composition consists essentially of (a) about 10 or about 50 mg/ml of an anti-C5 antibody, (b) about 0.01 to about 0.1% (w/v) of a surfactant, (c) about 1 to about 20 mM buffer having a pH of 5.5 to 7.5, and (d) a stabilizer selected from the group consisting of trehalose, sucrose, sorbitol, arginine, or a combination thereof. A method of treating a disorder in which C5 activity is detrimental in a subject comprising administering the stable aqueous composition to the subject also is provided.Type: ApplicationFiled: November 22, 2017Publication date: October 31, 2019Applicant: SAMSUNG BIOEPIS CO., LTDInventors: Jaemin LEE, Yuna SHON, Tae-Soo LEE, Brian Ho Sung MIN, YongKook KIM, Soojeong PARK, Sungjae PARK
-
Patent number: 10336828Abstract: A fusion polynucleotide including a murine CMV promoter and an intron, a recombinant vector including the fusion polynucleotide and a gene encoding a polypeptide of interest, a recombinant cell including the recombinant vector, and a method of producing a polypeptide of interest using the recombinant vector and/or the recombinant cell.Type: GrantFiled: December 7, 2015Date of Patent: July 2, 2019Assignee: SAMSUNG BIOEPIS CO., LTD.Inventors: Su Jeong Hwang, Min-Kyung Kim, Sangjoon Park, Chanmoo Lee, Mi Young Cho
-
Publication number: 20190085369Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.Type: ApplicationFiled: April 16, 2018Publication date: March 21, 2019Applicants: Biogen MA Inc., Samsung BioepisInventors: William C. Yang, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Liu Tsang, Thomas Ryll, Sangil Lee, Dae Sung Lee
-
Patent number: 10202456Abstract: Provided is a recombinant cell including inactivated pyruvate dehydrogenase kinase (PDK) gene, a composition for producing a polypeptide of interest including the recombinant cell, and a method of producing a polypeptide of interest using the recombinant cell.Type: GrantFiled: November 2, 2015Date of Patent: February 12, 2019Assignee: Samsung Bioepis Co., Ltd.Inventors: Eunyoung Park, Hye Young Suh, Hee Kyung Sung, Christina Yi, Sunkyu Kim
-
Patent number: 9944968Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.Type: GrantFiled: January 19, 2016Date of Patent: April 17, 2018Assignees: Biogen MA Inc., Samsung BioepisInventors: William Yang, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Tsang, Thomas Ryll, Sangil Lee, Dae Sung Lee
-
Publication number: 20170175075Abstract: The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.Type: ApplicationFiled: March 24, 2015Publication date: June 22, 2017Applicants: Biogen MA Inc., Samsung BioepisInventors: William YANG, Yao-Ming HUANG, Marty SINACORE, Thomas RYLL, Jiuyi LU, Jaesun LEE, Kyngju LEE, Hyoung Taek LIM, Eunchong YANG
-
Patent number: D833603Type: GrantFiled: December 26, 2017Date of Patent: November 13, 2018Assignee: Samsung Bioepis Co., Ltd.Inventors: Jee Eun Yang, Sang Bin Park, Jae Min Song, Yong Kook Kim
-
Patent number: D834183Type: GrantFiled: December 26, 2017Date of Patent: November 20, 2018Assignee: Samsung Bioepis Co., Ltd.Inventors: Jee Eun Yang, Sang Bin Park, Jae Min Song, Yong Kook Kim
-
Patent number: D855176Type: GrantFiled: December 26, 2017Date of Patent: July 30, 2019Assignee: Samsung Bioepis Co., Ltd.Inventors: Jee Eun Yang, Sang Bin Park, Jae Min Song, Yong Kook Kim
-
Patent number: D855451Type: GrantFiled: April 12, 2018Date of Patent: August 6, 2019Assignee: Samsung Bioepis Co., Ltd.Inventors: Na Young Kim, Hyung Kyoon Oh, Kyung Bok Lee
-
Patent number: D864379Type: GrantFiled: December 26, 2017Date of Patent: October 22, 2019Assignee: Samsung Bioepis Co., Ltd.Inventors: Jee Eun Yang, Sang Bin Park, Jae Min Song, Yong Kook Kim
-
Patent number: D867583Type: GrantFiled: December 26, 2017Date of Patent: November 19, 2019Assignee: Samsung Bioepis Co., Ltd.Inventors: Jee Eun Yang, Sang Bin Park, Jae Min Song, Yong Kook Kim
-
Patent number: D904878Type: GrantFiled: June 3, 2019Date of Patent: December 15, 2020Assignee: Samsung Bioepis Co., Ltd.Inventors: Jiwon Lee, Dongbo Choi
-
Patent number: D904879Type: GrantFiled: June 3, 2019Date of Patent: December 15, 2020Assignee: Samsung Bioepis Co., Ltd.Inventors: Jiwon Lee, Dongbo Choi
-
Patent number: D979053Type: GrantFiled: September 17, 2019Date of Patent: February 21, 2023Assignee: SAMSUNG BIOEPIS CO., LTD.Inventors: Tae Soo Lee, Min Jeong Kim, Ga Ram Kwak, Jun Geon Kwon