Abstract: The invention provides a composition comprising an anti-tumor necrosis factor (TNF)-alpha polypeptide, wherein the composition produces a reduced level of immunogenicity when administered to a subject, as well as a treatment method involving the administration of the composition.
Type:
Application
Filed:
October 31, 2019
Publication date:
February 27, 2020
Applicants:
SAMSUNG BIOEPIS CO., LTD., BIOGEN MA INC.
Inventors:
Jeehoon GHIL, Yoonseok LEE, Songyoung KIM, Orlando A. JAQUEZ, Robert S. GRONKE
Abstract: A stable aqueous composition comprising (a) about 10 to about 100 mg/ml of an anti-C5 antibody, (b) a surfactant, (c) a stabilizer, and (d) a buffer having a pH of about 5.0 to about 7.8, wherein the stabilizer is trehalose, sucrose, sorbitol, arginine, or a combination thereof is provided. In a particular embodiment, the stable aqueous composition consists essentially of (a) about 10 or about 50 mg/ml of an anti-C5 antibody, (b) about 0.01 to about 0.1% (w/v) of a surfactant, (c) about 1 to about 20 mM buffer having a pH of 5.5 to 7.5, and (d) a stabilizer selected from the group consisting of trehalose, sucrose, sorbitol, arginine, or a combination thereof. A method of treating a disorder in which C5 activity is detrimental in a subject comprising administering the stable aqueous composition to the subject also is provided.
Type:
Application
Filed:
November 22, 2017
Publication date:
October 31, 2019
Applicant:
SAMSUNG BIOEPIS CO., LTD
Inventors:
Jaemin LEE, Yuna SHON, Tae-Soo LEE, Brian Ho Sung MIN, YongKook KIM, Soojeong PARK, Sungjae PARK
Abstract: A fusion polynucleotide including a murine CMV promoter and an intron, a recombinant vector including the fusion polynucleotide and a gene encoding a polypeptide of interest, a recombinant cell including the recombinant vector, and a method of producing a polypeptide of interest using the recombinant vector and/or the recombinant cell.
Type:
Grant
Filed:
December 7, 2015
Date of Patent:
July 2, 2019
Assignee:
SAMSUNG BIOEPIS CO., LTD.
Inventors:
Su Jeong Hwang, Min-Kyung Kim, Sangjoon Park, Chanmoo Lee, Mi Young Cho
Abstract: Provided is a recombinant cell including inactivated pyruvate dehydrogenase kinase (PDK) gene, a composition for producing a polypeptide of interest including the recombinant cell, and a method of producing a polypeptide of interest using the recombinant cell.
Type:
Grant
Filed:
November 2, 2015
Date of Patent:
February 12, 2019
Assignee:
Samsung Bioepis Co., Ltd.
Inventors:
Eunyoung Park, Hye Young Suh, Hee Kyung Sung, Christina Yi, Sunkyu Kim