Patents Assigned to Samyang Genex Corporation
  • Patent number: 9290508
    Abstract: The present invention relates to a method for preparing high purity anhydrosugar alcohols using hydrogenated sugar, and more specifically, to a method for preparing high purity anhydrosugar alcohols (particularly, isosorbide, isomannide, isoidide, and the like) with a purity of 97.5% or higher (more preferably, 98.5% or higher) and a pH of a distillate of 3.7 or higher (more preferably, 4.0 or higher) in a distillation yield of 87% or higher (more preferably, 90% or higher) by adding an acid to hexitol so as to convert the same into anhydrosugar alcohols, and single-stage distilling the converted product by using an internal condenser type thin film evaporator.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: March 22, 2016
    Assignee: SAMYANG GENEX CORPORATION
    Inventors: Do Hyun Kyung, Young Jae Jung, Jin Kyung Kim, Hoon Ryu
  • Patent number: 9260447
    Abstract: The present invention relates to a technique for preparing an anhydrosugar alcohol using hydrogenated sugar as a raw material and, more specifically, to a technique for preparing a high-purity anhydrosugar alcohol by adding an acid to hydrogenated sugar (for example, hexitol) to convert same to an anhydrosugar alcohol, then distilling the converted liquid, and crystallizing the distilled liquid in a solvent, the technique removing a crystallization solvent from a crystallization mother liquor generated during a crystallization step and then introducing the resultant product together with the distilled liquid and the converted liquid into a distillation step, thereby being capable of improving the total distillation yield of the anhydrosugar alcohol, improving distillation efficiency by improving the mobility of a distillate, and further reducing the amount of generated waste and treatment costs and thus highly efficiently preparing the high-purity anhydrosugar alcohol at reduced costs.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: February 16, 2016
    Assignee: SAMYANG GENEX CORPORATION
    Inventors: Hoon Ryu, Young Jae Jung, Jin Kyung Kim, Do Hyun Kyung, Hyuk Min Park, Seong Ho Cho
  • Publication number: 20150353574
    Abstract: The present invention relates to a method for producing an anhydrosugar alcohol and, more specifically, to a method for producing an anhydrosugar alcohol which, when the step of subjecting a hydrogenated sugar to a dehydration reaction in a reactor so as to convert same to an anhydrosugar alcohol is performed, allows the hydrogenated sugar to be continuously introduced into the reactor and the produced anhydrosugar alcohol to be continuously discharged out of the reactor while the dehydration reaction is carried out, also prevents a reaction mixture from circulating inside and outside the reactor while the dehydration reaction is carried out, and thereby can significantly improve production efficiency compared with a conventional process adopting a batch or semi-batch-type dehydration reaction and thus can be appropriately applied particularly to a large-scale anhydrosugar alcohol production process.
    Type: Application
    Filed: February 21, 2014
    Publication date: December 10, 2015
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Hoon RYU, Young Jae JUNG, Jin Kyung KIM, Do Hyun KYUNG, Hyuk Min PARK, Seong Ho CHO
  • Publication number: 20150329448
    Abstract: The present invention relates to a method for preparing an anhydrosugar alcohol using hydrol (namely, a crystalline mother liquor remaining after obtaining crystalline glucose from a crude glucose liquor). More particularly, the present invention relates to a method for preparing an anhydrosugar alcohol in a method for performing a dehydration reaction on the hydrogenated sugar so as to convert the hydrogenated sugar to an anhydrosugar alcohol, wherein the method for preparing an anhydrosugar alcohol is configured to use, as at least a portion of the hydrogenated sugar, the product obtained from the hydrogenation of the hydrol which is a by-product or waste generated during the production of glucose, thus relatively lowering the cost for a material as compared with a case of using a high purity raw material (for example, high purity sorbitol), to thus improve economical advantages, and further reduce the amount of waste and cost for disposal of the waste during the production of glucose.
    Type: Application
    Filed: December 12, 2013
    Publication date: November 19, 2015
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Hoon RYU, Young Jae JUNG, Jin Kyung KIM, Do Hyun KYUNG, Hyuk Min PARK, Seong Ho CHO
  • Publication number: 20150307511
    Abstract: The present invention relates to a technique for preparing an anhydrosugar alcohol using hydrogenated sugar as a raw material and, more specifically, to a technique for preparing a high-purity anhydrosugar alcohol (in particular, isosorbide, isomannide, isoidide, and the like) having a purity of 98% or higher and containing less than 0.1% of sorbitol and a sorbitan isomer, which are impurities, in a high total distillation yield of 94% or higher (more preferably, 95% or higher) by adding an acid to hydrogenated sugar (for example, hexitol) to convert same to an anhydrosugar alcohol, and then distilling the converted liquid over two or more stages by sequentially using a combination of an external condenser type wiped film evaporator and an internal condenser type short path evaporator.
    Type: Application
    Filed: November 6, 2013
    Publication date: October 29, 2015
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Hoon RYU, Young Jae JUNG, Jin Kyung KIM, Do Hyun KYUNG, Hyuk Min PARK, Seong Ho CHO
  • Patent number: 9169180
    Abstract: The present invention relates to a method for preparing an anhydrosugar alcohol using hydrol (namely, a crystalline mother liquor remaining after obtaining crystalline glucose from a crude glucose liquor). More particularly, the present invention relates to a method for preparing an anhydrosugar alcohol in a method for performing a dehydration reaction on the hydrogenated sugar so as to convert the hydrogenated sugar to an anhydrosugar alcohol, wherein the method for preparing an anhydrosugar alcohol is configured to use, as at least a portion of the hydrogenated sugar, the product obtained from the hydrogenation of the hydrol which is a by-product or waste generated during the production of glucose, thus relatively lowering the cost for a material as compared with a case of using a high purity raw material (for example, high purity sorbitol), to thus improve economical advantages, and further reduce the amount of waste and cost for disposal of the waste during the production of glucose.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: October 27, 2015
    Assignee: SAMYANG GENEX CORPORATION
    Inventors: Hoon Ryu, Young Jae Jung, Jin Kyung Kim, Do Hyun Kyung, Hyuk Min Park, Seong Ho Cho
  • Patent number: 9169263
    Abstract: The present invention relates to a technique for preparing an anhydrosugar alcohol using hydrogenated sugar as a raw material and, more specifically, to a technique for preparing a high-purity anhydrosugar alcohol (in particular, isosorbide, isomannide, isoidide, and the like) having a purity of 98% or higher and containing less than 0.1% of sorbitol and a sorbitan isomer, which are impurities, in a high total distillation yield of 94% or higher (more preferably, 95% or higher) by adding an acid to hydrogenated sugar (for example, hexitol) to convert same to an anhydrosugar alcohol, and then distilling the converted liquid over two or more stages by sequentially using a combination of an external condenser type wiped film evaporator and an internal condenser type short path evaporator.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: October 27, 2015
    Assignee: SAMYANG GENEX CORPORATION
    Inventors: Hoon Ryu, Young Jae Jung, Jin Kyung Kim, Do Hyun Kyung, Hyuk Min Park, Seong Ho Cho
  • Publication number: 20150299216
    Abstract: The present invention relates to a method for preparing anhydrous sugar alcohol, and more particularly, to a cheap and highly efficient method for preparing anhydrous sugar alcohol having a high final purity of at least 99%, and having good ion content, pH, conductivity, and color properties. According to the method, a hydrogenated sugar is dehydrated so as to be transformed into anhydrous sugar alcohol, and a series of processes including distillation, crystallization, decoloration, and ion exchange resin treatment are conducted.
    Type: Application
    Filed: October 15, 2013
    Publication date: October 22, 2015
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Hoon RYU, Young Jae JUNG, Jin Kyung KIM, Do Hyun KYUNG, Hyuk Min PARK, Seong Ho CHO
  • Publication number: 20150252054
    Abstract: The present invention relates to a technique for preparing an anhydrosugar alcohol using hydrogenated sugar as a raw material and, more specifically, to a technique for preparing a high-purity anhydrosugar alcohol by adding an acid to hydrogenated sugar (for example, hexitol) to convert same to an anhydrosugar alcohol, then distilling the converted liquid, and crystallizing the distilled liquid in a solvent, the technique removing a crystallization solvent from a crystallization mother liquor generated during a crystallization step and then introducing the resultant product together with the distilled liquid and the converted liquid into a distillation step, thereby being capable of improving the total distillation yield of the anhydrosugar alcohol, improving distillation efficiency by improving the mobility of a distillate, and further reducing the amount of generated waste and treatment costs and thus highly efficiently preparing the high-purity anhydrosugar alcohol at reduced costs.
    Type: Application
    Filed: November 6, 2013
    Publication date: September 10, 2015
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Hoon Ryu, Young Jae Jung, Jin Kyung Kim, Do Hyun Kyung, Hyuk Min Park, Seong Ho Cho
  • Patent number: 9029578
    Abstract: A method is provided for the preparation of anhydrosugar alcohols. The method involves dehydration of a hexitol with a mixed acid of a first acid and second acid, in which the first acid is sulfuric acid and the second acid is at least one sulfur-containing acid or sulfur-containing acid salt selected from the group consisting of p-toluenesulfonic acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, naphthalenesulfonic acid and aluminum sulfate. Also provided are methods for purification of the resulting product.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: May 12, 2015
    Assignee: Samyang Genex Corporation
    Inventors: Hoon Ryu, Young Jae Jung, Young Seok Kim
  • Publication number: 20150112088
    Abstract: The present invention relates to a method for preparing high purity anhydrosugar alcohols using hydrogenated sugar, and more specifically, to a method for preparing high purity anhydrosugar alcohols (particularly, isosorbide, isomannide, isoidide, and the like) with a purity of 97.5% or higher (more preferably, 98.5% or higher) and a pH of a distillate of 3.7 or higher (more preferably, 4.0 or higher) in a distillation yield of 87% or higher (more preferably, 90% or higher) by adding an acid to hexitol so as to convert the same into anhydrosugar alcohols, and single-stage distilling the converted product by using an internal condenser type thin film evaporator.
    Type: Application
    Filed: May 9, 2013
    Publication date: April 23, 2015
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Do Hyun Kyung, Young Jae Jung, Jin Kyung Kim, Hoon Ryu
  • Publication number: 20150094477
    Abstract: The present invention relates to a production method for an anhydro sugar alcohol having a markedly reduced ion content and improved colour characteristics, and, more specifically, relates to a method for producing an anhydrous sugar alcohol having a markedly reduced ion content, markedly lowered electrical conductivity and improved colour characteristics, which is obtained by subjecting hydrogenated sugar (sugar alcohol) to a dehydration reaction and thereby converting same to an anhydrous sugar alcohol and then subjecting distilled water, which has been isolated through a distillation step, to a decolourizing process using activated carbon, and subsequently bringing the resulting decolourized substance into contact with an ion exchange resin.
    Type: Application
    Filed: May 9, 2013
    Publication date: April 2, 2015
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Young Jae Jung, Jin Kyung Kim, Do Hyun Kyung, Hoon Ryu
  • Publication number: 20140088315
    Abstract: Disclosed is a method for the preparation of an anhydrosugar alcohol using a starch-derived hexitol such as sorbitol or mannitol Anhydrosugar alcohol is in the form of a diol having two hydroxyl groups in the molecule thereof and has a very high utility value as a physical property modifier which can be used primarily in plastics. Representative examples of anhydrosugar alcohols include isosorbide and isomannide. These anhydrosugar alcohols are capable of increasing a glass transition temperature of and improving strength of PET, polyesters, polycarbonates, etc., and are therefore highly valuable as biodegradable environmentally-friendly bioplastics.
    Type: Application
    Filed: June 2, 2011
    Publication date: March 27, 2014
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Hoon Ryu, Young Jae Jung, Young Seok Kim
  • Publication number: 20130225803
    Abstract: The present invention relates to a method for preparing hydroxyalkyl starch. The method for preparing hydroxyalkyl starch comprises the steps of hydrolyzing starch, reducing the hydrolyzed starch, and substituting the reduced starch with hydroxyalkyl group in a dry process.
    Type: Application
    Filed: November 23, 2011
    Publication date: August 29, 2013
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Pil Nam Hong, Chang Heon Koh
  • Patent number: 8163940
    Abstract: This invention is directed to a method for the preparation of docetaxel having an amorphous, anhydrous crystalline, or hydrated crystalline structure. In accordance with the invention, highly pure amorphous, anhydrous crystalline, or hydrated crystalline docetaxel can be produced with a high yield by using a solvent precipitation method, colloid formation method, etc.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: April 24, 2012
    Assignee: Samyang Genex Corporation
    Inventors: Sang-Hyun Pyo, Jin-Suk Cho, Moon-Suk Kim, Bong-Kyu Song, Ho-Joon Choi
  • Publication number: 20120035379
    Abstract: Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of the stereochemical structure of a selectively separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.
    Type: Application
    Filed: December 3, 2009
    Publication date: February 9, 2012
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Sang-Hyun Pyo, Jin-Suk Cho, Moon-Suk Kim, Jai-Young Song, Ho-Joon Choi
  • Patent number: 8101411
    Abstract: The present invention relates to a method of producing corosolic acid by using plant cells that produce corosolic acid. More particularly, the present invention relates to a method of producing corosolic acid by using plant cell suspension cultures comprising the steps of: inducing a callus from a tissue of a plant producing corosolic acid; preparing a cell line capable of being cultured in liquid culture medium from the induced callus; culturing the cell line in a suspension culture; and isolating corosolic acid from the culture solution. The present invention has advantage of maximizing productivity by utilizing two-stage culture, treatment with inducing agent, and high cell-density culture in the suspension culture of plant cells producing corosolic acid.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: January 24, 2012
    Assignee: Samyang Genex Corporation
    Inventors: Chang-Heon Kim, Jin-Ah Kim, Jai-Young Song, Ho-Joon Choi
  • Patent number: 7880022
    Abstract: This invention is directed to a method for efficiently separating and purifying 13-dehydroxybaccatin III and 10-deacetylpaclitaxel with a high purity of 90% or higher purity, preferably 99.5% or higher purity, from taxane-containing materials such as Taxus species, and the thusly obtained highly pure 13-dehydroxybaccatin III and 10-deacetylpaclitaxel can be used as semi-synthetic precursors of paclitaxel and/or docetaxel that are anticancer agents.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: February 1, 2011
    Assignee: Samyang Genex Corporation
    Inventors: Sang-Hyun Pyo, Jin-Suk Cho, Moon-Suk Kim, Bong-Kyu Song, Ho-Joon Choi
  • Publication number: 20100159545
    Abstract: The present invention relates to a method of producing corosolic acid by using plant cells that produce corosolic acid. More particularly, the present invention relates to a method of producing corosolic acid by using plant cell suspension cultures comprising the steps of: inducing a callus from a tissue of a plant producing corosolic acid; preparing a cell line capable of being cultured in liquid culture medium from the induced callus; culturing the cell line in a suspension culture; and isolating corosolic acid from the culture solution. The present invention has advantage of maximizing productivity by utilizing two-stage culture, treatment with inducing agent, and high cell-density culture in the suspension culture of plant cells producing corosolic acid.
    Type: Application
    Filed: June 30, 2006
    Publication date: June 24, 2010
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Chang-Heon Kim, Jin-An Kim, Jai-Young Song, Ho-Joon Choi
  • Publication number: 20090018353
    Abstract: This invention is directed to a method for the preparation of docetaxel having an amorphous, anhydrous crystalline, or hydrated crystalline structure. In accordance with the invention, highly pure amorphous, anhydrous crystalline, or hydrated crystalline docetaxel can be produced with a high yield by using a solvent precipitation method, colloid formation method, etc.
    Type: Application
    Filed: November 2, 2006
    Publication date: January 15, 2009
    Applicant: SAMYANG GENEX CORPORATION
    Inventors: Sang-Hyun Pyo, Jin-Suk Cho, Moon-Suk Kim, Bong-Kyu Song, Ho-Joon Choi