Abstract: Systems and methods facilitating objective evaluations of subjects to facilitate detecting clinically relevant changes in balance are provided. The system includes a portable balance board with a sensor in each of four feet for detecting downward force. Each sensor is communicatively coupled to a circuit board with a wired or wireless communication capability. A subject stands on the balance board and each sensor sends a signal to the circuit board, which communicates the four signals to a companion device that uses the signals to calculate the center of pressure (“COP”) of the subject over time. The subject can perform the BESS test and the resulting COP data is used to calculate a field path length for the subject. The field path length is compared to a previously determined baseline path length for the subject to detect any clinically relevant change in balance of the subject.

Abstract: The present invention is directed to a system and method for photoeradication of microorganisms from a target. A light source is configured to irradiate the target with purple or blue light in a pulsed mode of irradiation at an average irradiance that preferably ranges from 0.1 mW/cm2 to 20 mW/cm2. An electronic circuit is configured to control the light source in accordance with an irradiation schedule that includes a plurality of irradiation sessions. The light source is controlled to provide the purple or blue light at a radiant exposure that preferably ranges from 0.5 J/cm2 to 60 J/cm2 during each of the irradiation sessions. The irradiation sessions are provided at a plurality of time intervals so as to cause photoeradication of all or a portion of the microorganisms.

Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.

Abstract: A device and method is described for electronic human prosthetics, and specifically a skull- and/or spine implantable bi-directional neural-communication/brain-machine interface (BBMI) device where the input, output and on-board computing are combined into a single unit to form a compact neuro-prosthetics device. This invention is also directed to a fully implantable wireless spinal electronic recording and stimulation system using the BBMI in a human. The bi-directional devices (BBMIs) communicate with other bi-directional brain-machine interface devices (BBMI) and/or with external controllers wirelessly. The compact implantable stimulator has ultrasonic secondary battery charging system. One or more BBMI can be wirelessly connected so that a closed loop of BBMIs, or a BBMI and an external controller, can wirelessly send trigger pulses to this fully implanted stimulator over the spinal cord.

Abstract: Materials and methods for treating an infection or disease, activating an immune cell at a site of infection or disease, and for directly killing microorganisms, using response-selective carboxy-terminal C5a analogs, are provided.

Abstract: A method for collecting and processing remotely sensed imagery in order to achieve precise spatial co-registration (e.g., matched alignment) between multi-temporal image sets is presented. Such precise alignment or spatial co-registration of imagery can be used for change detection, image fusion, and temporal analysis/modeling. Further, images collected in this manner may be further processed in such a way that image frames or line arrays from corresponding photo stations are matched, co-aligned and if desired merged into a single image and/or subjected to the same processing sequence. A second methodology for automated detection of moving objects within a scene using a time series of remotely sensed imagery is also presented. Specialized image collection and preprocessing procedures are utilized to obtain precise spatial co-registration (image registration) between multitemporal image frame sets.

Abstract: A device and method is described for electronic human prosthetics, and specifically a body-machine interface (BMI) device where the input, output and on-board computing are combined into a single unit to form a compact ECG, respiratory sensing, temperature-sensing-prosthetics device. The devices (BMIs) can also communicate with other body-machine interface devices (BMI) and/or with external controllers wirelessly. The compact device has ultrasonic battery charging system. One or more BMI can be wirelessly connected so that a closed loop of BMIs, or a BMI and an external controller, can wirelessly send trigger pulses to the stimulator over the heart, glossopharyngeal nerve(s) or diaphragm.

Abstract: This application relates to techniques for obtaining wide area intermittent video (WAIV). Some embodiments disclosed herein include a method of obtaining WAIV. The method can include, for example, capturing images at a series of sensor stations having pre-determined locations along a flightline. The flightline can be repeated one or more times, where images are captured at the same sensor stations with each pass of the flightline. The captured images from the same sensor station may have replicated view geometry and may be co-registered and precisely aligned with pixel-level precision. The captured images from multiple sensor stations through time may also be displayed together based upon absolute or relative sensor station locations to create a temporal sequence of wide area intermittent video. The approach provides efficient methods for creating wide area video with reduced temporal imaging frame rates. Systems and devices for forming wide area intermittent video are also disclosed.

Abstract: Disclosed herein, in certain embodiments, is a method of depositing a polymer onto a surface. In some embodiments, the method comprises using a high electric field and a high frequency vibratory motion to deposit a polymer solution onto the surface. Disclosed herein, in certain embodiments, is a method of manufacturing an electrode or diode. In some embodiments, the method comprises using a high electric field and a high frequency vibratory motion to deposit a polymer onto a surface. Further disclosed herein, in certain instances, is an electrode manufactured by any method disclosed herein. Further disclosed herein, in certain instances, is a diode manufactured by any method disclosed herein.

Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.

Abstract: The invention relates to a product and a process for fabricating a 1D, 2D, or 3D layered micro or nano component that comprises providing an electrode having a micro-scale or nano-scale tip, and applying electric current to the electrode tip in the presence of a micro-scale or nano-scale powder.

Abstract: The present invention relates to a recombinant methanotroph having an ability to produce isoprene and a method for producing isoprene using the same, and more particularly to a recombinant methanotroph having an ability to produce isoprene wherein a gene encoding an isoprene synthase having a homology of at least 70% to the amino acid sequence of Ipomoea batatas isoprene synthase is introduced into the recombinant methanotroph, and a method for producing isoprene using the recombinant methanotroph. The use of a recombinant methanotroph according to the present invention enables isoprene to be produced in high yield by using methane gas or methanol which is obtained from waste such as natural gas, biomass, municipal waste or the like as a carbon source.

Abstract: A method for collecting and processing remotely sensed imagery in order to achieve precise spatial co-registration (e.g., matched alignment) between multi-temporal image sets is presented. Such precise alignment or spatial co-registration of imagery can be used for change detection, image fusion, and temporal analysis/modeling. Further, images collected in this manner may be further processed in such a way that image frames or line arrays from corresponding photo stations are matched, co-aligned and if desired merged into a single image and/or subjected to the same processing sequence. A second methodology for automated detection of moving objects within a scene using a time series of remotely sensed imagery is also presented. Specialized image collection and preprocessing procedures are utilized to obtain precise spatial co-registration (image registration) between multitemporal image frame sets.

Abstract: A wearable electronic device for proximity-based social and professional networking which features electronics and software for the passive automated local wireless exchange of personal and/or business information with other electronic devices is disclosed. In some embodiments, an electronic device includes a controller having an operations unit; a communication unit configured to receive and/or transmit data from a first external source; and a memory unit configured to communicate with the controller and receive and/or transmit data from the controller. The operations unit may be configured to determine if received data from the first external source meets a set threshold and wherein the operations unit may be configured to instruct communication unit to accept data that meets or exceeds said threshold. The communication unit may receive and transmit data from the first external source provided the external source is within a predetermined proximity.

Abstract: Materials and methods for treating and preventing an infection or disease, and for directly killing microorganisms, using carboxy-terminal C5a analogs, are provided.

Abstract: The invention provides methods for preparing boronic acids, for example, primary alkyl or alkenyl boronic acids, and alkali metal alkyl trifluoro borate salts, as described herein, wherein the primary alkyl boronic acids and the potassium alkyl trifluoroborate salts can contain one or more unprotected functional groups.

Abstract: This application relates to techniques for obtaining wide area intermittent video (WAIV). Some embodiments disclosed herein include a method of obtaining WAIV. The method can include, for example, capturing images at a series of sensor stations having pre-determined locations along a flightline. The flightline can be repeated one or more times, where images are captured at the same sensor stations with each pass of the flightline. The captured images from the same sensor station may have replicated view geometry and may be co-registered and precisely aligned with pixel-level precision. The captured images from multiple sensor stations through time may also be displayed together based upon absolute or relative sensor station locations to create a temporal sequence of wide area intermittent video. The approach provides efficient methods for creating wide area video with reduced temporal imaging frame rates. Systems and devices for forming wide area intermittent video are also disclosed.

Abstract: The invention provides novel catalysts and methods of using catalysts for controlling the position of a double bond and cis/trans-selectivity in isomerization of terminal alkenes to their 2-isomers. Catalysts such as (pentamethylcyclopentadienyl)Ru formulas 1 and 3 having a bifunctional phosphine can be used in the methods. A catalyst loading of 1 mol % of formulas 1+3 can be employed for the production of (E)-2-alkenes at 40-70° C.; lower temperatures can be used with higher catalyst loading. Acetonitrile-free catalysts can be used at lower loadings, room temperature, and in less than a day to accomplish the same results as catalysts 1+3. The novel catalyst systems minimize thermodynamic equilibration of alkene isomers, so that the trans-2-alkenes of both non-functionalized and functionalized alkenes can be generated.

Abstract: The invention is directed to compositions to screen for small molecule drugs that inhibit proteases, such as viral proteases, e.g., HIV proteases; and methods for making and using these compositions. The invention provides compositions and methods for identifying compositions, e.g., drug molecules, that can inhibit proteases, e.g., HIV proteases. In alternative embodiments, the invention provides cell-based assays to screen for compositions, e.g., small molecules or drugs, that inhibit or modify the activity of enzymes such as calcium-dependent protein convertases involved in HIV envelop protein processing, including cleavage of the HIV gp160 envelope precursor, resulting in gp120 and gp41 envelope products.

Abstract: Microelectromechanical system are disclosed that include at least one electrode, microelectrode or combination thereof, wherein the at least one electrode comprises a carbon material, a glassy carbon material or a combination thereof. Contemplated systems are suitable for ?-ECoG arrays. Additional microelectromechanical systems are disclosed that include at least one electrode, microelectrode or combination thereof, wherein the at least one electrode comprises a carbon material, a glassy carbon material or a combination thereof; at least one substrate, surface, layer or a combination thereof, wherein the at least one electrode, microelectrode or combination thereof is disposed on, coupled with or otherwise layered on the at least one substrate, surface, layer or a combination thereof; and at least one bump pad, wherein the at least one electrode, microelectrode or combination thereof is coupled with the at least one bump pad via at least one conductive metal.