Abstract: Systems for piezoelectric composite materials are described. Various piezoelectric composite material structures and configurations can be incorporated into piezoelectric panels. Various methods are described to recycle and heal various piezoelectric composite materials.

Abstract: Disclosed is a platform for fluorescence imaging of bulk RNA dynamics in living cells. The platform utilizes a technique including exposing a plurality of live cells configured to overexpress a WT or mutant ribonucleoside kinase UCK2 under control of an inducible promoter, a constitutively active promoter, or both, to a first quantity of a fluorescent nucleoside (such as fluorescent bicyclic and tricyclic cytidine analogues) for a first period of time.

Abstract: The invention relates to a process for fabricating complex mechanical shapes, and in particular to fabricating complex mechanical shapes using a pressure-assisted sintering technique to address problems relating to variations in specimen thickness and tooling, or densification gradients, by 3-D printing of a polymer model that is surrounded by and filled with sintering powder material, wherein the 3-D polymer model decomposed into a graphite interface layer and facilitates release of the cast, e.g. metal, metal-alloy, ceramic, etc., manufactured item.

Abstract: In alternative embodiments, provided are products of manufacture and kits, and methods, to enrich for and/or isolate microbes such as viruses and/or phages capable of targeting, e.g., binding to, targeting, and/or killing or otherwise making non-viable or non-pathogenic, specific or desired microbes such as bacteria. In alternative embodiments, provided are products of manufacture comprising: a virus and/or a phage (a bacteriophage). In alternative embodiments, provided are products of manufacture and kits containing a virus and/or a phage (a bacteriophage) enriched for, selected for or isolated by a method as provided herein, or a microbe containing a virus and/or a phage (a bacteriophage) enriched, selected for and/or isolated by a method as provided herein.

Abstract: A method for designing a channel estimation and data detection networks is provided herein. The problem of channel estimation for linear systems has effectively been solved—not the case for non-linear systems. A deep learning framework for channel estimation, data detection, and pilot signal design is described to address the nonlinearity in such systems.

Abstract: The embodiments described herein relate generally to medical devices that measure vital signs, and more particularly to wearable wireless devices that collect multiple simultaneous vital signs, and systems and methods for compressing the sensor data into a matrix representation to facilitate collecting, transmitting, processing, and displaying vital sign data.

Abstract: A lock for a lid of a receptacle such as a trash can comprises a gravity pin, a torsion spring, a lower pin, and a latch. The lock can be mounted to the receptacle and lid. The gravity pin and latch operate to substantially prevent the receptacle lid from inadvertently opening, while automatically allowing the lid to open when the receptacle is inverted. Also provided are lids and receptacles comprising lid locks as provided herein.

Abstract: A meta-material is disclosed that includes a first layer composed of graphene, and one or more additional layers, each composed of glassy carbon or graphene. A method of producing an engineered material includes depositing a graphene precursor on a substrate, pyrolyzing the graphene precursor to allow the formation of graphene, depositing a glassy carbon precursor the graphene, pyrolyzing to allow the formation of glassy carbon from the glassy carbon precursor, depositing a graphene precursor on the glassy carbon, and pyrolyzing the graphene precursor to allow the formation of graphene.

Abstract: Provided are compositions and methods for treating, ameliorating and preventing infections, disorders and conditions in mammals, including genetically-predisposed and chronic disorders, where a microbial or bacterial flora is at least one causative or symptom-producing factor. Provided are compositions and methods used to treat, prevent or ameliorate an infection, for example, an infection in the gastrointestinal tract, or bowel.

Abstract: Provided herein are systems and methods for an iterative approach to topic modeling and the use of web mapping technology to implement advanced spatial operators for interactive high-dimensional visualization and inference.

Abstract: Herein reported are new tricyclic cytidine compounds, such as 8-diethylamino-tC (8-DEA-tC), that respond to DNA and/or RNA duplex formation with up to a 20-fold increase in fluorescent quantum yield as compared with the free nucleoside, depending on neighboring bases. This turn-on response to duplex formation is by far the greatest of any reported nucleoside analogue that can participate in Watson-Crick base pairing. Measurements of the quantum yield of 8-DEA-tC mispaired with adenosine and, separately, opposite an abasic site show that there is almost no fluorescence increase without the formation of correct Watson-Crick hydrogen bonds. Kinetic isotope effects from the use of deuterated buffer show that the duplex protects 8-DEA-tC against quenching by excited state proton transfer. DFT calculations provide a rationale for the observed photophysical properties that is dependent on duplex integrity and the electronic structure of the analogue.

Abstract: The invention relates to a process for fabricating complex mechanical shapes, and in particular to fabricating complex mechanical shapes using a pressure-assisted sintering technique to address problems relating to variations in specimen thickness and tooling, or densification gradients, by 3-D printing of a polymer model that is surrounded by and filled with sintering powder material, wherein the 3-D polymer model decomposed into a graphite interface layer and facilitates release of the cast, e.g. metal, metal-alloy, ceramic, etc., manufactured item.

Abstract: Computer-assisted methods for assisting in anomaly identification relating to a dysmorphology analysis comprise retrieving and/or generating a sequence of progressively changing images that depict morphing of at least a subject's first physical feature, between at least a first state representing an identification of a first anomaly relating to a dysmorphology and a second state representing lack of the identification of the first anomaly. The number of images in the sequence is selected to provide a substantially continuous transition between the first and second states. The retrieved and/or generated images are displayed on a display of a processing device, and a user interface on the processing device is provided for a user to make an image selection, which can then be used to determine identification or lack of identification of the anomaly.

Abstract: A probe device is disclosed that includes one or more insulating layers and a glassy carbon layer. The glassy carbon layer includes one or more channels. Each channel includes a microstructure, which may include an electrode region, interconnect region, and bump pad region. The electrode region may be placed in contact with a human or animal patient or test subject and used to collect or deliver signals in applications such as electrocorticography (ECoG), electromyography (EMG), and neural stimulation. A method of making a probe includes depositing a glassy carbon precursor on a substrate, patterning the precursor using photolithography, pyrolyzing the precursor to allow the formation of glassy carbon, and depositing one or more insulating layers.

Abstract: Systems, apparatus, and methods for channel estimation and data detection. In one exemplary embodiment, the data is obtained in a two-phase transmission structure that alternates known data with unknown data according to a regular or otherwise pre-determined time interval. Then, the receiver iteratively updates a postulated channel, and provides a predicted channel to the next time slot. Conceptually, the exemplary techniques iteratively improve its postulates for channel condition and data over multiple time slots. More directly, instead of linear detection and decoding of a pilot for channel estimation in each time slot, the exemplary techniques described herein use postulated channel conditions to attempt data detection and use the recovered data from data detection (unknown data) to re-postulate the channel conditions, etc. until channel conditions are stable and/or the next time slot is ready for processing.

Abstract: The invention relates to a process for fabricating complex mechanical shapes from metal or ceramic, and in particular to fabricating complex mechanical shapes using a pressure-assisted sintering technique to address problems relating to variations in specimen thickness and tooling, or densification gradients, by 3-D printing of a sacrificial, self-destructing powder mold is created using e.g. alumina and swellable binders such as polysaccharides. The binder-free sintering powder that forms the manufactured item is injected into the mold, and high pressure is applied. The powder assembly can then be sintered by any pressure assisted technique to full densification and the self-destructing mold allows the release of the fully densified complex manufactured item.

Abstract: In alternative embodiments, provided are compositions and methods for making a chimeric polypeptide comprising an S-layer polypeptide and a heterologous polypeptide or peptide. In alternative embodiments, the compositions and methods comprise recombinantly engineering a methylotrophic or methanotrophic bacteria to recombinantly express a chimeric polypeptide comprising an S-layer polypeptide and a heterologous polypeptide or peptide. Also provided are compositions and methods for displaying or immobilizing proteins on a methanotrophic S-layer. In alternative embodiments, provided are compositions and methods comprising recombinant methylotrophic or methanotrophic bacteria comprising assembled or self-assembled recombinant or isolated chimeric S-layer polypeptides. In alternative embodiments, provided are compositions and methods using recombinant methylotrophic or methanotrophic bacteria, optionally a Methylomicrobium alcaliphilum, optionally a M. alcaliphilum sp.

Abstract: Herein reported are new tricyclic cytidine compounds, such as 8-diethylamino-tC (8-DEA-tC), that respond to DNA and/or RNA duplex formation with up to a 20-fold increase in fluorescent quantum yield as compared with the free nucleoside, depending on neighboring bases. This turn-on response to duplex formation is by far the greatest of any reported nucleoside analogue that can participate in Watson-Crick base pairing. Measurements of the quantum yield of 8-DEA-tC mispaired with adenosine and, separately, opposite an abasic site show that there is almost no fluorescence increase without the formation of correct Watson-Crick hydrogen bonds. Kinetic isotope effects from the use of deuterated buffer show that the duplex protects 8-DEA-tC against quenching by excited state proton transfer. DFT calculations provide a rationale for the observed photophysical properties that is dependent on duplex integrity and the electronic structure of the analogue.

Abstract: Apparatus for near-field wireless energy transfer. A first layer provides or comprises a piezoelectric phase or a material with or adapted for electromechanical coupling; and a second layer provides or comprises a magnetostrictive phase or a material with or adapted for a magnetomechanical coupling. The second layer is mechanically and/or chemically coupled to the first layer to provide a composite structure.

Abstract: A meta-material is disclosed that includes a first layer composed of graphene, and one or more additional layers, each composed of glassy carbon or graphene. A method of producing an engineered material includes depositing a graphene precursor on a substrate, pyrolyzing the graphene precursor to allow the formation of graphene, depositing a glassy carbon precursor the graphene, pyrolyzing to allow the formation of glassy carbon from the glassy carbon precursor, depositing a graphene precursor on the glassy carbon, and pyrolyzing the graphene precursor to allow the formation of graphene.