Abstract: Location-based virtual queuing of vehicles is described. A request to join a virtual queue may be received from a user application. In response to receiving the request, the server may determine, using a geo-fencing feature, if the user computing device running the user application is within a first predetermined distance of a queue location, where the queue location is a destination of the requesting user vehicle. Then, in response to receiving confirmation that the requesting vehicle user is within the first predetermined distance, the server may automatically create and add a reservation message to a data structure that includes a plurality of reservation messages. Also, in response to the creating the reservation message, the server may provide the requesting user application a notification with the position within a queue managed by the data structure and an estimated wait time that is generated using information stored within the data structure.

Abstract: A management system for a Permitting Authorities (PA) or their appointed designee to monitor and track application-based commercial ground transportation (ABCT) providers activities within electronically-enabled geo-fenced areas associated with the PAs, all without the need for specialized hardware such as transponders or other tracking equipment. ABCT Providers transmit location and/or transaction information for ABCT Vehicles within geo-fenced areas associated with the PAs to a clearinghouse. The clearinghouse parses the location and/or transaction information to identify the corresponding PA. The clearinghouse transmits the received information to the corresponding PAs in near real-time and periodically creates invoices for each PA based on the activities taken place within the respective goes-fenced areas.

Abstract: Methods and systems are described herein for facilitating blockchain operations in decentralized applications by offering enhanced efficient when conducting blockchain operations using cryptography-based, digital ledgers through the use of specialized indexing. For example, as opposed to relying on raw blockchain data to power decentralized applications, the methods and systems use a blockchain indexer. The blockchain indexer provides a queryable record of a subset of blockchain operations.

Abstract: A management system for a Permitting Authorities (PA) or their appointed designee to monitor and track application-based commercial ground transportation (ABCT) providers activities within electronically-enabled geo-fenced areas associated with the PAs, all without the need for specialized hardware such as transponders or other tracking equipment. ABCT Providers transmit location and/or transaction information for ABCT Vehicles within geo-fenced areas associated with the PAs to a clearinghouse. The clearinghouse parses the location and/or transaction information to identify the corresponding PA. The clearinghouse transmits the received information to the corresponding PAs in near real-time and periodically creates invoices for each PA based on the activities taken place within the respective goes-fenced areas.

Abstract: A management system for a Permitting Authorities (PA) or their appointed designee to monitor and track application-based commercial ground transportation (ABCT) providers activities within electronically-enabled geo-fenced areas associated with the PAs, all without the need for specialized hardware such as transponders or other tracking equipment. ABCT Providers transmit location and/or transaction information for ABCT Vehicles within geo-fenced areas associated with the PAs to a clearinghouse. The clearinghouse parses the location and/or transaction information to identify the corresponding PA. The clearinghouse transmits the received information to the corresponding PAs in near real-time and periodically creates invoices for each PA based on the activities taken place within the respective goes-fenced areas.

Abstract: A management system for a Permitting Authorities (PA) or their appointed designee to monitor and track application-based commercial ground transportation (ABCT) Providers activities within electronically-enabled geo-fenced areas associated with the PAs, all without the need for specialized hardware such as transponders or other tracking equipment. ABCT Providers transmit location and/or transaction information for ABCT Vehicles within geo-fenced areas associated with the PAs to a clearinghouse. The clearinghouse transmits the location and/or transaction information to a clearinghouse. The clearinghouse transmits the received information to the corresponding PAs in near real-time and periodically creates invoices for each PA based on the activities taken place within the respective goes-fenced areas.

Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.

Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.

Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.

Abstract: A management system for a Permitting Authorities (PA) or their appointed designee to monitor and track application-based commercial ground transportation (ABCT) Providers activities within electronically-enabled geo-fenced areas associated with the PAs, all without the need for specialized hardware such as transponders or other tracking equipment. ABCT Providers transmit location and/or transaction information for ABCT Vehicles within geo-fenced areas associated with the PAs to a clearinghouse. The clearinghouse transmits the location and/or transaction information to a clearinghouse. The clearinghouse transmits the received information to the corresponding PAs in near real-time and periodically creates invoices for each PA based on the activities taken place within the respective goes-fenced areas.

Abstract: A management system for a Permitting Authority (PA) or its appointed designee to monitor and track application-based commercial ground transportation (ABCT) Provider activity through the ABCT-Driver's mobile device, the ABCT-Provider's app, the ABCT-Provider's computer systems, and the PA's electronically-enabled geo-fence, all without the need for specialized hardware such as transponders or other tracking equipment. Each mobile communication device associated with an ABCT-Vehicle continually transmits information to an ABCT-Provider Information and Communications Technology (“ICT”) System associated with an ABCT-Provider when an application on the mobile communication device is active. The information transmitted by the mobile communication device enables the ABCT-Provider ICT System to identify and monitor the ABCT-Driver's identity, the vehicle information, the geographic locus, and/or the ABCT-Vehicle's activity data.

Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.

Abstract: Device for assisting crawling of an infant (2) on a training surface comprising: - a platform (1) comprising a chest supporting surface for supporting a chest of the infant (2) resting on the platform (1) in a prone position, and - rolling elements (9) rotatably mounted on the platform in such a way they can rotate 360 degrees (1) and arranged to be located between the platform (1) and the training surface, wherein the platform (1) is shaped so that, when the rolling elements (9) are in contact with the training surface, the chest supporting surface of the platform (1) is inclined relative to the training surface, so that the pelvis and the legs of the infant (2) are in contact with the training surface.

Abstract: Device for assisting crawling of an infant (2) on a training surface comprising: —a platform (1) comprising a chest supporting surface for supporting a chest of the infant (2) resting on the platform (1) in a prone position, and —rolling elements (9) rotatably mounted on the platform in such a way they can rotate 360 degrees (1) and arranged to be located between the platform (1) and the training surface, wherein the platform (1) is shaped so that, when the rolling elements (9) are in contact with the training surface, the chest supporting surface of the platform (1) is inclined relative to the training surface, so that the pelvis and the legs of the infant (2) are in contact with the training surface.

Abstract: This invention offers an effective method of inhibiting the growth of toxic bloom algae caused by cyanobacteria Mycrocystis aeruginosa in freshwater environments comprising administering an effective amount of 5,6-dichlorogramine to the freshwater. Also, the invention offers an effective method of inhibiting the growth of toxic bloom algae caused by M. aeruginosa comprising administering an effective amount of 5,6,7-trichlorogramine to the freshwater. Both compounds, 5,6-dichlorogramine and 5,6,7-trichlorogramine, may be administered individually or in combination to the freshwater. Both compounds are individually very potent and only need to be administered at a very low concentration to be effective at inhibiting the growth of M. aeruginosa in freshwater environments. Both 5,6-dichlorogramine and 5,6,7-trichlorogramine are each individually effective at inhibiting M. aeruginosa at low concentrations, between about 0.01 mg/L and about 0.05 mg/L, or more specifically at a concentration of about 0.03 mg/L.

Abstract: A system for auto-anastomosing a region of the body using magnetic members that may be individually delivered to different locations in the body. The magnetic members have a polar alignment that generates an attractive force to compress tissue in the region between them. The tissue in the region necroses as a result of the compressive force such that tissue surrounding the necrosed tissue heals together to form an anastomosis. A cutting member may be coupled to either the first or second magnetic member to create a temporary opening in the tissue.

Abstract: The invention provides methods for treating neurological disorders, which involve administering therapeutic agents to the thalamus by convection enhanced delivery.

Abstract: Methods and apparatus for incrementally manipulating an internal body member of a patient are disclosed. The apparatus has a magnetic implant adapted to be received on a location of the body member, a platform external to the patient, and a magnetic member coupled to the platform, wherein the magnetic member generates a magnetic force between the implant and the platform to incrementally manipulate the body member. The implant and external magnetic member are preferably rare earth magnets or an array of rare earth magnets, and are configured to generate an attractive or repulsive force between the implant and the platform to reposition, reorient, deform, or lengthen the body member.

Abstract: Methods of preparing monoclonal antibodies that differentially bind to a single conformer of a protein of interest are described. Passive immunization using these antibodies as well as use of conformer-specific antibodies as diagnostic reagents for the purpose of stratification of patient populations with regards to disease outcome, drug efficacy or drug sensitivity is also disclosed as well as active immunization with the protein conformer. In the screening techniques, detection can be for example by tissue immunostaining, western blotting or solution IP. A specific mab termed 7VC which shows conformation specificity to CtmPrP, a prion protein conformer that triggers neurodegeneration under specific assay conditions of pH and copper concentration, is described. A second specific antibody termed 19B10 shows conformation specificity for NtmPrP, a prion protein conformer that downregulates total PrP expression and effects cell differentiation.