Patents Assigned to Sanbio, Inc.
  • Patent number: 12357761
    Abstract: A method of preparing a syringe in connection with a therapeutic treatment is disclosed. The method can include removing a plunger of the syringe from a barrel of the syringe, aligning the barrel in a horizontal orientation, filling a lumen of the barrel with a viscous material through an opening at a proximal end of the barrel, and inserting a plunger tip into the lumen to seal the lumen. The method can also include attaching an implantation device to a hub coupled to the barrel at a distal end of the barrel. The method can also include depressing the plunger until the cell suspension fills the implantation device and a droplet of the cell suspension is expelled from a distal tip of the implantation device.
    Type: Grant
    Filed: August 8, 2022
    Date of Patent: July 15, 2025
    Assignee: SanBio, Inc.
    Inventor: Michael McGrogan
  • Publication number: 20250064860
    Abstract: Disclosed herein are methods and compositions for stimulating angiogenesis, using cells descended from marrow adherent stromal cells that have been transfected with sequences encoding a Notch intracellular domain. Applications of these methods and compositions include treatment of ischemic disorders such as stroke.
    Type: Application
    Filed: November 8, 2024
    Publication date: February 27, 2025
    Applicant: SanBio, Inc.
    Inventors: Monique DAO, Ciara TATE, Casey C. CASE
  • Publication number: 20250009804
    Abstract: Disclosed are methods of treating a subject following a small-volume ischemic stroke suffered by the subject and methods of treating a subject with a stroke-induced motor deficit. Disclosed also is a composition for treating small-volume ischemic stroke. In one aspect, the method of treating a subject following a small-volume ischemic stroke comprises administering, to a brain region surrounding a small-volume ischemic core of the subject, a therapeutically effective amount of cells, wherein the cells are descended from mesenchymal stem cells transiently-transfected by a polynucleotide encoding a Notch intracellular domain.
    Type: Application
    Filed: September 17, 2024
    Publication date: January 9, 2025
    Applicant: SanBio, Inc.
    Inventor: Bijan NEJADNIK
  • Patent number: 12171787
    Abstract: Disclosed herein are methods and compositions for stimulating angiogenesis, using cells descended from marrow adherent stromal cells that have been transfected with sequences encoding a Notch intracellular domain. Applications of these methods and compositions include treatment of ischemic disorders such as stroke.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: December 24, 2024
    Assignee: SanBio, Inc.
    Inventors: Monique Dao, Ciara Tate, Casey C. Case
  • Patent number: 12121544
    Abstract: Disclosed are methods of treating a subject following a small-volume ischemic stroke suffered by the subject and methods of treating a subject with a stroke-induced motor deficit. Disclosed also is a composition for treating small-volume ischemic stroke. In one aspect, the method of treating a subject following a small-volume ischemic stroke comprises administering, to a brain region surrounding a small-volume ischemic core of the subject, a therapeutically effective amount of cells, wherein the cells are descended from mesenchymal stem cells transiently-transfected by a polynucleotide encoding a Notch intracellular domain.
    Type: Grant
    Filed: May 24, 2022
    Date of Patent: October 22, 2024
    Assignee: SanBio, Inc.
    Inventor: Bijan Nejadnik
  • Publication number: 20240226174
    Abstract: Disclosed herein are methods and compositions for the use of marrow adherent stem cells and their descendants; e.g., bone marrow-derived neural regenerating cells; for provision of angiogenic factors to cells. In certain embodiments, provision of angiogenic factors to sites of neural degeneration stimulates growth and/or survival of host neurons.
    Type: Application
    Filed: March 14, 2024
    Publication date: July 11, 2024
    Applicant: SanBio, Inc.
    Inventors: Keita MORI, Martha C. BOHN, Ciara TATE, Irina AIZMAN, Aleksandra GLAVASKI, Tamas VIRAG
  • Publication number: 20240200035
    Abstract: Described herein are methods and culture medium, useful for inducing polarization in multipotent stem cells. Additionally, described herein are multipotent cells produced by the methods and culture medium of this disclosure that are useful therapeutic agents. Also described herein are extracellular vesicles and factors secreted by multipotent cells that are produced by the methods and culture medium of this disclosure that are useful as therapeutic agents.
    Type: Application
    Filed: February 28, 2024
    Publication date: June 20, 2024
    Applicant: SanBio, Inc.
    Inventors: Aline M. BETANCOURT, Ruth S. WATERMAN, Thomas F. ISETT
  • Publication number: 20240139255
    Abstract: Disclosed herein are cell preparations useful for modulating various peripheral immune functions, methods for making said cell preparations, and methods for their use.
    Type: Application
    Filed: January 9, 2024
    Publication date: May 2, 2024
    Applicant: SanBio, Inc.
    Inventors: Mo DAO, Casey C. CASE
  • Patent number: 11946072
    Abstract: Described herein are methods and culture medium, useful for inducing polarization in multipotent stem cells. Additionally, described herein are multipotent cells produced by the methods and culture medium of this disclosure that are useful therapeutic agents. Also described herein are extracellular vesicles and factors secreted by multipotent cells that are produced by the methods and culture medium of this disclosure that are useful as therapeutic agents.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 2, 2024
    Assignee: SanBio, Inc.
    Inventors: Aline M. Betancourt, Ruth S. Waterman, Thomas F. Isett
  • Patent number: 11903972
    Abstract: Disclosed herein are cell preparations useful for modulating various peripheral immune functions, methods for making said cell preparations, and methods for their use.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: February 20, 2024
    Assignee: SanBio, Inc.
    Inventors: Mo Dao, Casey C Case
  • Publication number: 20220387506
    Abstract: Disclosed are methods of treating a subject following a small-volume ischemic stroke suffered by the subject and methods of treating a subject with a stroke-induced motor deficit. Disclosed also is a composition for treating small-volume ischemic stroke. In one aspect, the method of treating a subject following a small-volume ischemic stroke comprises administering, to a brain region surrounding a small-volume ischemic core of the subject, a therapeutically effective amount of cells, wherein the cells are descended from mesenchymal stem cells transiently-transfected by a polynucleotide encoding a Notch intracellular domain.
    Type: Application
    Filed: May 24, 2022
    Publication date: December 8, 2022
    Applicant: SanBio, Inc.
    Inventor: Bijan NEJADNIK
  • Publication number: 20220379030
    Abstract: A method of preparing a syringe in connection with a therapeutic treatment is disclosed. The method can include removing a plunger of the syringe from a barrel of the syringe, aligning the barrel in a horizontal orientation, filling a lumen of the barrel with a viscous material through an opening at a proximal end of the barrel, and inserting a plunger tip into the lumen to seal the lumen. The method can also include attaching an implantation device to a hub coupled to the barrel at a distal end of the barrel. The method can also include depressing the plunger until the cell suspension fills the implantation device and a droplet of the cell suspension is expelled from a distal tip of the implantation device.
    Type: Application
    Filed: August 8, 2022
    Publication date: December 1, 2022
    Applicant: SanBio, Inc.
    Inventor: Michael McGROGAN
  • Patent number: 11512284
    Abstract: There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: November 29, 2022
    Assignee: SanBio, Inc.
    Inventors: Mari Dezawa, Hajime Sawada, Hiroshi Kanno, Masahiko Takano
  • Patent number: 11439761
    Abstract: A method of preparing a syringe in connection with a therapeutic treatment is disclosed. The method can include removing a plunger of the syringe from a barrel of the syringe, aligning the barrel in a horizontal orientation, filling a lumen of the barrel with a viscous material through an opening at a proximal end of the barrel, and inserting a plunger tip into the lumen to seal the lumen. The method can also include attaching an implantation device to a hub coupled to the barrel at a distal end of the barrel. The method can also include depressing the plunger until the cell suspension fills the implantation device and a droplet of the cell suspension is expelled from a distal tip of the implantation device.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: September 13, 2022
    Assignee: SanBio, Inc.
    Inventor: Michael McGrogan
  • Patent number: 11406685
    Abstract: Disclosed herein are methods and compositions for providing mixtures of FGF2 isoforms that are biologically active. The biological activities include, but are not limited to, stimulation of proliferation of neural precursor cells, stimulation of proliferation of endothelial cells, stimulation of development of neural precursor cells, and stimulation of development of astrocytes.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: August 9, 2022
    Assignee: SanBio, Inc.
    Inventors: Irina Aizman, Damien Bates
  • Publication number: 20220193144
    Abstract: Disclosed herein are methods and compositions for stimulating angiogenesis, using cells descended from marrow adherent stromal cells that have been transfected with sequences encoding a Notch intracellular domain. Applications of these methods and compositions include treatment of ischemic disorders such as stroke.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 23, 2022
    Applicant: SanBio, Inc.
    Inventors: Monique DAO, Ciara TATE, Casey C. CASE
  • Patent number: 11124771
    Abstract: Methods for selecting lots of bone marrow stromal cells (MSCs) having a high proliferative capacity are provided. Such methods are useful in the manufacture of therapeutic derivatives of MSCs.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: September 21, 2021
    Assignee: SanBio, Inc.
    Inventor: Irina Aizman
  • Patent number: 11046929
    Abstract: Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell phenotypes to selectively promote or suppress inflammation and immunity, yielding polarized, primed, activated, or induced cells used in cell-based therapy.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: June 29, 2021
    Assignee: SanBio, Inc.
    Inventor: Aline Betancourt
  • Publication number: 20210062140
    Abstract: Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell phenotypes to selectively promote or suppress inflammation and immunity, yielding polarized, primed, activated, or induced cells used in cell-based therapy.
    Type: Application
    Filed: November 12, 2020
    Publication date: March 4, 2021
    Applicant: SanBio, Inc.
    Inventor: Aline BETANCOURT
  • Publication number: 20200354709
    Abstract: Disclosed herein are methods for the treatment of traumatic brain injury by transplantation of cells descended from marrow adherent stem cells that express an exogenous Notch intracellular domain. The transplanted cells form a pathway along which endogenous neurogenic cells proliferate and migrate from the subventricular zone to the site of injury.
    Type: Application
    Filed: March 5, 2020
    Publication date: November 12, 2020
    Applicants: SanBio, Inc., University of South Florida
    Inventors: Cesar V. BORLONGAN, Casey C. CASE