Abstract: Various reconfigurable phononic devices, including phase shifters, mirrors, Mach Zehnder interferometers, memories, and transducers for use in both classical and quantum computing systems are disclosed. The individual phononic devices may be combined in various configurations to implement desired, more complex functionality. The phononic devices may be coupled together to implement the desired functionality using phononic waveguides. The phononic devices include one or more phase shifters that are operationally based on either hyperelasticity or a moving boundary effect.

Abstract: The present invention is directed to an electro-optical sensor for high intensity electric field measurement. The electro-optical sensor was used to measure a strong 118 MV/m narrow pulse width (˜33 ns) electric field in the magnetically insulated transmission line (MITL) of a pulsed power accelerator. Accurately measuring these high fields using conventional pulsed power diagnostics is difficult due to the strength of interfering particles and fields. The electro-optical sensor uses a free space laser beam with a dielectric crystal sensor that is highly immune to electromagnetic interference and does not require an external calibration.

Abstract: A method for matching neural network layouts to hardware architectures is provided. The method comprises iteratively: holding neural network parameters constant while changing a hardware architecture parameters, calculating a first loss value for a combination of the neural network parameters and hardware architecture parameters according to a gradient-based differentiable function within specified resource constraints, holding the hardware architecture parameters constant while changing the neural network parameters, calculating a second loss value for a new combination of parameters within the specified resource constraints, and combining the first loss value and the second loss value to calculate a combined loss value. The above iterative steps are stopped when the combined loss value reaches a specified threshold, and an optimal combination of neural network parameters and hardware architecture parameters is determined according to the combined loss value.

Abstract: A method and system architecture for designing a compressive sensing matrix for machine learning includes receiving an image associated with a classification task and; generating a sensing matrix. The sensing matrix includes an array of nonzero elements of the image. A prism array of prism elements is in communication with the sensing matrix. A row of values corresponding with an input angle of the prism array is mapped to a respective column corresponding with a detector. Then the detector detects light refracted at an output angle dictated by the physical shape of the prism element. A physical model of the detector is fabricated and generates a compressed representation of the image. A machine learning classification algorithm is applied to the compressed representation of the image and generates an optimized non-invertible final determination of the image.

Abstract: An article, for example, an integrated circuit (IC), is manufactured such that the article includes an authentication element that is indicative of an authentication code associated with the article. A block of a blockchain ledger is generated based upon the authentication code. After the article leaves a trusted chain of custody, the article can be authenticated based upon the blockchain. An authentication code can be read from an authentication element included in or on an article under test that is of undetermined authenticity. The authentication code can be evaluated against the blockchain to determine if the authentication code is a genuine code used to generate a block of the blockchain. If the authentication code is genuine, the article under test can be authenticated.

Abstract: A radiation detector includes a photodetector and a scintillator coupled thereto. The scintillator is formed of a scintillator material comprising an organic glass scintillator (OGS) material and at least one of a polymer additive or a plasticizer additive. The scintillator emits light when radiation is received at the scintillator, and the light is received by the photodetector. The radiation detector can further include a frame that has an interior cavity that holds the scintillator in position with respect to the photodetector, such that the light emitted by the scintillator is transmitted to the photodetector. The scintillator can be formed by casting amorphous scintillator material in the interior cavity of the frame. The frame can then be coupled to the photodetector to form the radiation detector.

Abstract: Provided herein are single domain antibodies (sdAbs) configured for passing the blood brain barrier in a human or mammal brain. Methods of using such sdAbs are also described herein, such as methods of binding to brain cells, binding with and transporting other sdAbs with beneficial functionalities, binding to and transporting biochemical or pharmaceutical species with beneficial functionalities, and treating, diagnosing, or prophylactically treating a disease, malignancy, or condition.

Abstract: Provided herein are asymmetric biparatopic neutralizing nanobody-based antibodies which engage SARS-2 spike in at least two independent epitopes. Several biparatopic constructs showed synergy in neutralizing viral infection of cells. Data also showed that single biparatopic constructs are more effective than the combination of the parental monotopic constructs were at neutralization. The nanobodies that were identified in an initial screen of a large and highly diverse library bind to a single epitope that overlaps with the ACE2 binding site.

Abstract: A method for direct write printing of an electrical or optical element based upon a generated master actual position map and a master expected position map is disclosed. The generated master actual position map is generated by efficiently stitching together a number of images using a hierarchical stitching process. Once the desired location of the electrical or optical element is determined by comparing the master actual position map with the master expected position map, a corresponding toolpath for a direct write printer is generated. The direct write printer then direct write prints the electrical or optical element using the generated toolpath. By using different types of inks, the electrical element may be a trace, a resistor, an inductor, a transformer, a capacitor, or some combination thereof. In like manner, the optical element may be a waveguide, a beam-splitter, a phase shifter, an optical attenuator, an interferometer, or some combination thereof.

Abstract: A large and highly diverse nanobody library was constructed and screened against multiple variants of SARS-COV-2 to find nanobodies with high sensitivity and specificity for the variants. Four rounds of positive selection against a panel of six diverse SARS-COV-2 variant RBDs was performed with our high-diversity. At least 59 of these nanobodies were found to work well against Alpha, Beta, Gamma, Delta, Kappa, Lambda and Mu with some overlap efficacy against other variants. These nanobodies have efficacy as stand-alone nanobodies and as a construct comprising nanobodies linked to the human IgG1 constant fragment (Fc) (nanobody-hFc constructions or nb-hFcs) to make enhanced humanized sdAbs with all the attributes of nanobodies with improved half-life and optimized effector functions. Several promising nanobodies that neutralize the original SARS-COV-2 and several of its variants have been identified, including Delta, with high efficacy. In particular, a subset of these nanobodies bind to the Omicron RBD.

Abstract: A magnetic micro-device and process to manufacture the same is disclosed. The magnetic micro-device has a near-zero conductivity magnetic nanocomposite film layer with a plurality of apertures through which a corresponding plurality of electrical conductors (vias) pass. Due to the near-zero conductivity of the magnetic nanocomposite film layer, the vias are self-insulating. The presence of the magnetic nanocomposite film layer results in greater inductance than that possible with an air core (or core-less) magnetic micro-device. Potential magnetic micro-devices include toroid micro-inductors, solenoid micro-inductors, toroid micro-transformers, and solenoid micro-transformers. Additional potential magnetic micro-devices include generators, motors, electromagnetic switches, and voice coils (for speakers or microphones). The process used to manufacture the magnetic micro-device can be scaled to cost-effectively produce large numbers of the magnetic micro-device.

Abstract: A low noise amplifier (LNA) offering one or more of the following benefits: increased gain, reduced power consumption, and/or reduced area, while achieving a similar noise figure, is disclosed. The LNA achieves these benefits by employing an inductorless chip design, current reuse among the transistors, bias sharing, limited AC coupling capacitors, common gate input device feedback, and careful sizing of the transistors.

Abstract: The present invention relates to systems including an acoustic wave resonator and an active shunt capacitance cancelling oscillator circuit. Such systems can be used in biosensing methods, while avoiding impedance distortion and phase shift anomalies.

Abstract: A computer-implemented method of reconstructing boundaries from a computed tomography (CT) image dataset is provided. The method comprises receiving CT image data and applying a number of image filters to the CT image data. A numerical derivative is applied to the filtered CT image data to flatten and suppress non-edge regions that do not correspond to edges. Numerical derivative values are clipped to a specified range to reduce artifacts and noise, and an X-ray image is reconstructed according to the image filters and clipped numerical derivative values.

Abstract: A pixelated electronic sensor is disclosed for imaging from infra-red to ultraviolet wavelengths, composed of a CMOS integrated circuit plus layers of nano-materials monolithically integrated via low temperature post-processing. Co-design, simulation, and integration methods for the device are described. Each pixel has color-resolved single photon sensitivity without dark counts and without inefficiency. The device operates at temperatures above 70° Kelvin. Current state of the art imagers that can color-resolve single photons are of bolometric or filter type. Bolometric devices must operate at temperature below 1° Kelvin and are limited to few pixels. Devices that use filters are inefficient as all the photons rejected by a filter are wasted. Single photon imagers that operate at non-cryogenic temperature (like Silicon Photomultipliers) have large dark counts typically measured in MHz/cm2.

Abstract: A two-terminator RF adapter for background noise measurement in a test environment comprises a system test port comprising a system test port termination and a system test port connector to connect to a system under test; and a data acquisition port, comprising a data acquisition port termination and a data acquisition port connector to connect to a data acquisition system.

Abstract: A fuel for an internal combustion engine includes a C5 to C30 dialkoxyalkanoate corresponding to formula (I): wherein the R1 group is —H or a —CH3 group, the R2 and R2? groups are alkyl groups independently selected to have 1 to 9 carbon atoms; and the R3 group is selected to have 1 to 9 carbon atoms. The compounds described herein may be used as neat fuels or mixed fuels (with diesel, biodiesel, jet fuel, marine fuel or other fuel compounds) in autoignition or spark ignition engines, such as diesel engines, gasoline (spark ignition) engines, MCCI, Homogeneous Charge Compression Ignition (HCCI) engines, or more generally in Low-Temperature Gasoline Combustion (LTGC) engines (using gasoline-like fuels), that have the high-efficiency advantages of HCCI but can operate with some level of charge inhomogeneities. Methods of making these compounds are environmentally friendly and can be done in a continuous manner.

Abstract: A radiation-hardened (rad-hard) computing system can include a rad-hard processor, a second processor, and a memory operably coupled to the rad-hard processor. The rad-hard processor can cause the second processor to execute compute-intensive tasks that can be performed more quickly or with fewer computing resources by the second processor than the rad-hard processor. The rad-hard processor can selectively cause the second processor to execute a compute-intensive task based upon determining that the second processor is in a normal operating state. The rad-hard processor can further evaluate computing results generate by the second processor to determine whether such computing results meet an applicable acceptability condition. The rad-hard processor can employ a computing result that meets an applicable acceptability condition in further computing operations.

Abstract: An ionogel is formed by mixture of precursors, a catalyst, and an ionic liquid to form a sol-gel. The precursors and the catalyst react to form a solid-phase matrix that includes pores, wherein the ionic liquid is disposed within the pores. The gel is dried by way of thermal or vacuum drying to remove liquid byproducts of the precursor-catalyst reaction and to form a solid-state ionogel that comprises the solid-phase matrix with the ionic liquid disposed therein. The ionogel is immersed in a quantity of a liquid electrolyte that is soluble in the ionic liquid. As the liquid electrolyte dissolves into the ionic liquid, the ionic liquid is displaced by the liquid electrolyte, yielding an ionogel having the liquid electrolyte disposed within its pores.

Abstract: The casting material may be formed around the casting core using a variety of conventional casting techniques including direct liquid metal infiltration, pressure assisted casting, and centrifugal casting among others.